Just released—a brand new special issue focused entirely on interoception. More to follow, but beyond my usual excitement is the fact that this will be kickstarting 2021!!! https://t.co/CA9GDtqybC

🚀 GET EXCITED! The @ScottRussoPhD #BrainBodyResearchInstitute Seminar Series returns Jan 27th to launch an exciting 2026 season. Join us for cutting-edge talks from leaders in #BrainBody research. See you there! RSVP👉 https://t.co/QbQh989vnD

Thread summarizing this project below

Perceptual Dysregulation in Psychiatric Nosology has been released! I'm pleased to see that the cover is pretty close to my initial mockup. You can find the entire collection here:

This project was funded by the @NIMHgov and the NIGMS🙏 The manuscript was led by the outstanding @Ch_Verdonk and supported by a stellar team of collaborators including @RyanSmith_LIBR @mpwpaulus Jenny Stewart, Scott Moseman, Ahmad Mayeli, Emily Choquette & Keller Mink. /End

These findings show how gut-brain science could transform eating disorder care—offering scalable biomarkers for relapse and paving the way for personalized treatments.

Most striking: altered gut perception patterns predicted six-month relapse risk and eating disorder symptom severity. This is the first evidence that gut interoception can forecast relapse in AN. Full details in our new preprint: https://t.co/JogsSXFnLs

What we found: AN individuals missed more gut signals despite intact brain/body responses. ❌ Computational models showed biased expectations & reduced precision 🧠 Capsule stimulation also triggered greater hunger increases in AN 🍽️

We tested whether gastrointestinal #interoception, the brain’s ability to sense gut signals, might reveal hidden vulnerabilities. Using an ingestible vibrating capsule, we measured behavior, brain activity (EEG), and physiology as participants detected gut sensations.

Anorexia nervosa (AN) is one of the deadliest psychiatric disorders. Despite treatment, relapse rates remain high—and clinicians have no objective tools to track recovery.

Even after recovery, relapse is heartbreakingly common in anorexia nervosa. Could the answer lie in the gut’s hidden signals? 🧵

In doing so, these efforts may help lay the groundwork for a revised nosology—one rooted not in symptom checklists or clusters, but in empirically grounded models of sensory inference, brain-body interaction, and bodily regulation.

This volume grew from a @ACNPorg study group convened in 2022. These perspectives offer both novel treatment targets and a path to link latent computational processes with observable symptoms.

Finally, Jungilligens & @DavidLewisPerez show how functional neurological disorder may stem from erroneous brain-body integration, highlighting predictive processing as a driver of motor and sensory symptoms, expectation, self-agency, & illness beliefs.

Woelk and Garfinkel @DrSFink explore ways that dissociation may reflect a breakdown in interoceptive precision, disrupting body integration by uncoupling body signals from the sense of self and agency.

@NegarFani, Fulton & Botzanowski show how trauma can blunt or amplify body signal sensing, highlighting interoception as a target for fostering resilience.

Franco-O’ Byrne, Santamaría-García & @AgustinMIbanez argue that in frontotemporal dementia, disrupted interoceptive inference may drive autonomic chaos and social-emotional changes, pointing to the need to develop predictive coding–based therapies.

Reilly, Brown & @GuidoFrank link altered taste, touch, vision, and gut sensing to anorexia and bulimia nervosa, highlight knowledge gaps, and proposing neurobiologically-informed strategies for clinical translation.

Mehta, @mpwpaulus & @RyanSmith_LIBR consider how characterizing individuals using computational measures may facilitate diagnostic subgroup identification, symptoms due to pathway-specific abnormalities, or be helpful in predicting treatment responders.

Diaz-Fong & Feusner @BDD_anorexia show how in body dysmorphic disorder, distorted appearance perception may stem from overfocused detail processing—offering visual neuroscience insights for perceptual retraining.

Vassall & Wallace @VanderbiltBrain argue that multisensory integration differences have surprising overlaps between autism and schizophrenia, offering new clues for remediation.