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Best answer: Maybe Older guidelines have suggested that Enterococcus spp can be ignored in polymicrobial cultures from diabetic foot infections, however, newer guidelines do not specifically address. The overall data to answer this clinical question is poor. Although success has

👴 has a diabetic foot 🦶 infection requiring surgery. Operative cultures grow ESBL E. coli and E. faecalis. The E. coli is resistant to quinolones and TMP-SMX. Would you use ertapenem monotherapy for home antibiotics?

Can I use Ceftriaxone Monotherapy? Check out this week’s KASIC pearl to learn about Enterococcal Coverage in Diabetic Foot Infections. https://t.co/3ulI0ul7es #IDTwitter #IDXPosts #AntimicrobialResistance #antimicrobialstewardship #rxtwitter #pharmacy #FOAMed #NPs #PAs

Best answer: Yes Ciprofloxacin is not a respiratory fluoroquinolone because it does not have reliable activity against Streptococcus pneumoniae. However, it i can still be used for pneumonia caused by other organisms for which it has activity. For example, ciprofloxacin is a

👷 is started on cefepime and vancomycin for pneumonia. Sputum cultures return with pan-susceptible Pseudomonas aeruginosa. Can ciprofloxacin be used?

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Best answer: No Fluoroquinolone and tetracycline serum concentrations are reduced when co-administered with polyvalent cation containing medication such as antacids and vitamins. This may increase risk for clinical failure and emergence of drug-resistant bacteria. If unable to

👩‍🦰 is started on oral ciprofloxacin for a UTI. They have a history of iron deficient anemia. Can they take cipro and iron supplements at the same time?

This Heartburn feels like an Uncontrolled Infection! Check out this week’s KASIC pearl to learn about Chelation with Fluoroquinolones and Tetracyclines https://t.co/B7935wgq4f @KYHealthAlerts @KYIPTraining @KYAbxAwareness @KYHospitals @KAHCF1 @KyMedDirectors @SIDPharm

🧵 3/3 Best answer: Yes Unlike Citrobacter freundii, Citrobacter koseri and Citrobacter amalonaticus do not harbor a chromosomal ampC gene and are therefore not at risk for developing resistance while on treatment with beta-lactams such as ceftriaxone or piperacillin-tazobactam.

🧵 2/x Two days later, final identification and susceptibilities reveal a C. koseri susceptible to cefazolin. Can antibiotics be deescalated to cefazolin?

👩‍🦳 is admitted with pyelonephritis. Blood cultures 🩸grow a GNB that is identified as a Citrobacter spp by rapid diagnostics and cefepime is selected for treatment. 🧵 1/x

Shelf the Cefepime! Check out this week's KASIC pearl to learn about a Species Spotlight: Citrobacter koseri & Citrobacter amalonaticus https://t.co/PvoyipIOXu #IDTwitter #IDXPosts #AntimicrobialResistance #antimicrobialstewardship #rxtwitter #pharmacy #FOAMed #NPs

Best answer: No Enterococcus gallinarum is intrinsically resistant to vancomycin. While daptomycin and linezolid are considered “go-to” antibiotics for VRE, vancomycin resistant E. faecalis, E. gallinarum, and E. casseliflavus often remain susceptible to penicillins. Daptomycin

👨‍🔧 has a diabetic foot osteomyelitis🦶. Blood cultures 🩸grow vancomycin-resistant Enterococcus gallinarum which is susceptible to ampicillin. The patient is on empiric vancomycin and piperacillin-tazobactam💉. Should vancomycin be changed to daptomycin for this VRE?

Don’t Touch that Dapto! Check out this week’s KASIC pearl to Not Let the Bug Beat You: E. casseliflavus and E. gallinarum https://t.co/81xRPdAqll #IDTwitter #IDXPosts #AntimicrobialResistance #antimicrobialstewardship #rxtwitter #pharmacy #FOAMed #NPs @KYHealthAlerts

Best answer: No MSSA commonly makes a penicillinase and should be considered resistant to penicillin, amoxicillin, and ampicillin unless unique susceptibility testing confirms activity. Even when confirmed, penicillin is not recommended in some severe infections such as

🧑‍🦰has pneumonia🫁. A sputum culture grows methicillin-susceptible S. aureus susceptible to oxacillin, amoxicillin-clavulanate, and cefazolin. Oral amoxicillin is initially ordered. Is this appropriate?

Pondering Penicillin? Check out this week’s KASIC pearl to learn that when it comes to Penicillin for S. aureus, Is it Aye or Nay? https://t.co/QJIkpoLzxK #IDTwitter #IDXPosts #AntimicrobialResistance #antimicrobialstewardship #rxtwitter #pharmacy #FOAMed #NPs #PAs