For us ID doctors, the CDC has been a rock. Data, guidelines, surveillance, travel advice -- all there, vetted by experts, referenced, reliable. Perfect? No. But watching its dismantling now breaks my heart. Some thoughts:

Implementation of Diagnostic Stewardship to Improve Urinary Tract Infection Antibiotic Use Across Three Medical Centers ✅ Just Accepted https://t.co/7uE5O49C9q

In @CIDJournal, @ClaeysKcclaeys and colleagues examined interventions for urine culture ordering, processing, and reporting across three diverse Veterans Affairs (VA) hospitals and evaluated the interventions’ impact on antimicrobial use.

In this study that included 42067 adults in 🇺🇸, long-acting lipoglycopeptides (laLGPs) were effective as step-down treatment of serious gram +ve bacterial infections, offering comparable outcomes (readmission/ED visit/90d inpatient☠️) vs SOC antibiotics https://t.co/Dd0ZE6qAk4

https://t.co/aiw6MryB4g

Does anyone know why bezlo was discontinued? Seems no reason given? @mmPharmD

Rates of post procedural prophylactic antibiotic use following cardiac implantable electronic device insertion and … https://t.co/RSLTmGdZSX 🫀 Good news: declining rate of use. Bad news: use in 40% of patients. Keflex chaser most commonly used. @MayoClinicINFD @MayoClinicCV

Executive Summary: State-of-the-Art Review: Evaluation and Management of Pelvic Osteomyelitis in Stage IV Pressure Injuries: A Multidisciplinary Collaborative Approach https://t.co/DKGDTQfNJt

In 2 weeks! 😍

Viewpoint discusses the @US_FDA’s authorization of marketing an at-home testing system for chlamydia and gonorrhea as a good first step in boosting access to screening and treatment and in reducing infection rates.

🔥DOTS🔥 The most anticipated RCT #ESCMIDGLOBAL2024 Dalbavancin is non-inferior to SOC by clinical efficacy for complicated SAB incl Rt sided IE 2 doses Dalba 1500 mg on days 1 & 8 or 4-8 wks of SOC(cefaz or naf:MSSA;vanc or dapto:MRSA) DOOR at D70 Slides shared by @LordAlirezaF

Lets talk about Antibiotic PK. This week's 🧵: Distribution! This is where the drug goes after it's absorbed/injected. Where it goes = what target sites it can be used at. Main drug factors: Hydrophilic vs Lipophilic, plasma protein binding, and peripheral tissue binding 1/9

Hospitals testing for C diff using “flipped algorithm” of PCR -> toxin appear “better” in public reporting with less risk of financial penalty. BUT, these hospitals only publicly report 37% of patients who received treatment for C diff.

A #Mustread 🔥 #IDXposts EnJoY

Is the practice of preoperative urine culture associated with 🔽 risk of postoperative UTI or SSI? Hopefully,the results of this 🆕️🔥study can change the potentially harmful practice of urine testing & antibiotic use in asymptomatic pts prior to surgery! https://t.co/VPMrKQ1ppM

Asymptomatic Testing of Hospital Admissions for SARS-CoV-2: Is it OK to Stop? 🆓 Freely Available https://t.co/OCPkbUfUjp

Impact of SARS-CoV-2 Arrival Surveillance Screening by Nucleic Acid Amplification Versus Rapid Antigen Detection on Subsequent COVID-19 Infections in Military Trainees 🆓 Freely Available https://t.co/Z3TgoVULUq

MRSA Bacteremia: Vanco alone ✅️ most of the time Combination : Vanco + Rifampin ❌️ Vanco+ Genta ❌️ Vanco + ASP ❌️ Exebacase + Vanco/ Dapto❌️ NeXt ? SNAP Vanco+ Cefazolin ⁉️ We need to rethink our approach! #IDXposts

How good is a negative MRSA nasal swab for ruling out MRSA infection at various sites? NPV for infection in the: ✅Bloodstream: 96.5% ✅Abdomen: 98.6% ✅Respiratory tract: 96.1% ✅Wounds: 93.1% ✅Urinary tract: 99.2% Pretty dang good! https://t.co/lvudAQIZWD

🆕️✨️Single center retrospective study @OFIDJournal Comparative Effectiveness of Fidaxomicin compared to Vancomycin in Populations with Immunocompromising Conditions for the Treatment of Clostridioides difficile Infection #idxposts #MedEd https://t.co/QtWGjon5EU