Joshua Sailer
@JoshKSailer
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Post-Doc in the Alexanian Lab – UNC Chapel Hill Studying Radical Chemistry for C–H Functionalization
Joined May 2024
Another late post – We show that dirhodium catalysts are especially equipped to form azaspirocyclopropanes, a hot motif in med chem right now! Big shout out to Duc as he was the first to recognize this valuable motif!
pubs.acs.org
Spirocyclopropanes have become a prevalent structural motif in drug discovery campaigns. However, methods to generate these spirocyclopropanes stereoselectively are scarce, highlighting the need for...
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A little late, but excited to share our recent article out in JACS! We show an expedient synthesis of bicyclo[1.1.1]pentanes using two sequential diazo reactions. This work would not hav been possible without Duc Ly. Enjoy! https://t.co/EosamaaqLM
pubs.acs.org
2-Substituted bicyclo[1.1.1]pentane carboxylates have been synthesized using two sequential carbene reactions. A dirhodium-catalyzed intramolecular cyclopropanation to form a bicyclo[1.1.0]butane is...
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This summer I had the opportunity to go to Vienna to present my work at the ACS Publication Symposium: Catalysis for Organic Synthesis. There I was awarded one of the 6 poster awards! Read about it in this article from ACS Axial!
axial.acs.org
Learn more about each of the winners, gain insight into their research inspirations, and view their winning posters.
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Really enjoyed reading this new work out of the Glorius group - and not just because they use diazos! I particularly like how they indicate the subtle affects the ester group can have on the stability of the diazo compound. Congrats to all!
pubs.acs.org
Atomic carbon and its corresponding masked analogues are exceedingly underexplored intermediates in synthesis. Despite this, these reagents possess inimitable reactivity such as the ability to...
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Congrats to Will and the team at BMS! Really nice study out in ACS Med Chem Lett. And Editors' Choice!
Out in ACS Med Chem Lett as an Editors' Choice article: In collaboration with BMS, a systematic dirhodium-enabled study of how stereochemistry can dramatically effect neosubstrate degradation by IMiDs! https://t.co/5OhxRxKwUv
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Really enjoyed reading this paper that was reported yesterday in Nature Catalysis from the Dell'amico group. These aza-bicyclobutanes have interesting reactivity! Love thinking about the new disconnections that come from these types of molecules. https://t.co/WVA9jErloh
nature.com
Nature Catalysis - Four-membered rings have become popular motifs in drug discovery, prompting the synthetic organic chemistry community to develop more expedite approaches to access these...
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