James Hutchinson
@James_Hutc
Followers
53
Following
66
Media
7
Statuses
109
Our trial protocol is out - first-in-human allogeneic macrophages for the treatment of paracetamol liver injury. Can they fill the gap between acetylcysteine and transplant? https://t.co/iLdzuEy0zb
@EdinClinTox
bmjopen.bmj.com
Introduction Acute liver failure (ALF) has no effective treatment other than liver transplantation and is commonly caused by paracetamol overdose. New treatments are needed to treat and prevent ALF....
0
2
0
Proteolytic shedding of CD46 from human hepatocytes indicates liver stress: Heliyon
cell.com
Routine liver function tests capture information about the metabolic and inflammatory condition of the liver, but we lack sensitive biomarkers of early hepatocyte stress. In humans, soluble CD46...
0
0
1
Don't miss our collaborative study proposing combined therapy for #MultipleSclerosis Targeting #AhR w/ #DMF restores #tolerogenic #DendriticCells properties | A basis for new clinical trials @FedericoFonde @Eva_M_C @GTRecerca @CarrerasIJC @hgermanstrias
https://t.co/eMHGkMTxbs
1
10
34
The August issue of Transplantation picked-up Dataset Restriction as a Research Highlight. Find the full article by Collin Z Jordan at
journals.lww.com
An abstract is unavailable.
0
2
2
Combination cell therapy leads to clonal deletion of donor-specific T cells in kidney transplant recipients - eBioMedicine
thelancet.com
Overall, our data indicate that combining Treg cell therapy with CKBMT dampens the alloimmune response to transplanted kidneys in humans in the absence of myelosuppression.
0
0
1
Social media and scientific publishing. Why it's important for authors and readers to follow articles from Transplantation and Transplantation Direct. Our editor @BaanCarla explains!
0
8
19
Restriction also helps with intraclass heterogeneity. An unanticipated consequence of restriction is that disease biomarkers with a bimodal distribution in the positive class, such as might arise from multiple aetiologies, are findable. #biomarkers #predictive_models #ROC_curve
1
1
3
Applying restriction as a pre-processing step typically improves the performance of multivariate models.
1
1
1
Restriction is a procedure that splits datasets into classifiable and unclassifiable samples to define a biomarker’s informative and uninformative ranges.
1
1
2
Our new paper in Nat Comms tackles the special challenge of unequal variability between classes for immune biomarker discovery and interpretation. We introduce Dataset Restriction as a solution that can be extended to any classification task. https://t.co/RSfD5PlM3r
nature.com
Nature Communications - Immune disease-associated biomarker values are commonly more variable in affected compared to unaffected patient populations, which limits a biomarker’s informative...
1
2
3
Health implies homeostasis, whereas disease means dysregulation. It shouldn’t surprise us that disease markers are often more variably expressed in patients than controls @ExtraHorizon_ @INsTRuCT_h2020 @GGlehr @die_paloma
#melanoma #irAE
1
2
4
IL-4+ iNKT cells are a mechanistically surprising subset in hepatic steatosis that certainly deserve more attention. Congratulations to Florian, Paul, Raphael and Giulia!
Promising new marker of early liver disease that links hepatocyte stress in fatty liver disease with iNKT cell activation in patients with MASLD: Soluble CD46 as a diagnostic marker of hepatic steatosis
0
0
2
Congratulations Maria for graduating Cum Laude! @INsTRuCT_h2020 👩🏻🎓
0
0
1
Immune profiling of adipose tissue lymphocytes from patients with peritoneal carcinomatosis undergoing CRS-HIPEC leads to interesting new hypotheses. Good job, Julia!
link.springer.com
Cancer Immunology, Immunotherapy - Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment option for peritoneal carcinomatosis (PC) from...
0
0
3
New article by Florian and Jordi - well done. Case report: Predictability of clinical response and rejection risk after immune checkpoint inhibition in liver transplantation
0
0
1
The Extra project is looking for PhD candidates: ✅If you are willing to relocate to Barcelona ✅Have a background in translational Immunology & flow cytometry ✅ Are interested in the field of solid organ transplantation Please check out the link (workpack DoC9) @Inmunocanruti
1
8
10
exTra is a spin-off from INsTRuCT focused on apoptotic cell therapy in solid organ transplantation. If you’re looking for a PhD project with translational relevance, apply to exTra before 15th August, 2023.
exTra opened a call for 11 MSCA PhD Student positions to train in Basic and Translational Immunology. Projects in DE, AT, UK, NL and ES. Apply through EURAXESS.
0
2
4
Our new article about dataset restriction was released today as a #preprint on @researchsquare:
researchsquare.com
Immunological diseases are typically heterogeneous in clinical presentation, severity and response to therapy. Markers of immune diseases often reflect this variability, especially compared to their...
0
2
5