Jacob F Degner
@JacobFDegner
Followers
438
Following
798
Media
12
Statuses
384
Principal Research Scientist, Computational Genomics, Genetics Research Center @AbbVie All views expressed are my own.
North Chicago, IL
Joined April 2012
This paper helps calm my nagging worry that maybe we've all been wrong about genetics and drug success. By looking at a completely new dimension of drug success/failure, they reaffirm the effect we have seen using target-indication pair progression. https://t.co/9Wnr9yprnT
nature.com
Nature Genetics - Natural language processing of stopped clinical trials finds associations with the strength and extent of genetic evidence, suggesting that incorporating such evidence during...
0
0
0
I see that the internet is loving this new paper, but has the internet read the wonderful opinion on it by my former postdoc Emily King?
lnkd.in
This link will take you to a page that’s not on LinkedIn
Genetic evidence halves the odds of early clinical trial stoppage 🧬💊 Published today in @NatureGenet, @lesya_rzvvsk trained a machine learning classifier to analyse the free-text reasons explaining why 28,842 clinical trials stopped 3 key points: https://t.co/buMPpOQzPk
0
1
4
Genetic evidence halves the odds of early clinical trial stoppage 🧬💊 Published today in @NatureGenet, @lesya_rzvvsk trained a machine learning classifier to analyse the free-text reasons explaining why 28,842 clinical trials stopped 3 key points: https://t.co/buMPpOQzPk
nature.com
Nature Genetics - Natural language processing of stopped clinical trials finds associations with the strength and extent of genetic evidence, suggesting that incorporating such evidence during...
1
30
76
There is a position on my new team that just opened! We are looking for a creative and talented data scientist or statistical geneticist to help us use human genetics to drive value in drug development. https://t.co/53mEML1xr2
0
3
2
We are building a new bioinformatics team at AbbVie that will work on design and optimization of novel biotherapeutics including rAAV based therapies. Please reach out and apply if you are interested! Here are the job postings: https://t.co/nYkywdDHuw
https://t.co/UP7kEi3q96
0
0
2
Psychosocial experiences modulate asthma-associated genes through gene-environment interactions. Now epub in eLife. Lead by PhD student Justyna Resztak https://t.co/3Ab8S1ypV2
2
15
40
There's another job opening in my department! Please follow up with me if you are interested or know a good candidate! #hiring #jobs #bioinformatics #abbvie #pharma
https://t.co/6CnVRxVAk5
0
3
4
I'm excited to see the work from @jkpritch's former students and grand-students at the reunion symposium! Great talk from @HannahMoots on ancestry and relatedness of ancient Mediterranean civilization kicks it off.
0
0
6
How many SNPs do you need to estimate colocalization probabilities? One! Another great paper from Emily King's postdoc.
bmcbioinformatics.biomedcentral.com
Background Colocalization is a statistical method used in genetics to determine whether the same variant is causal for multiple phenotypes, for example, complex traits and gene expression. It...
0
2
3
I was happy to contribute to this paper with my former postdoc Minal. She used text mining and some serious brute force to try to understand how our community is approaching GWAS fine mapping. Your feed back is welcome! https://t.co/fXld96XFj7
2
23
60
It's great to see the NCAA's enthusiasm for coalescent theory.
2
9
78
I'm looking to hire in the Computational Genomics - "Special Projects" group at AbbVie! The group addresses an an exciting and always changing set of projects and problems. Come join us! https://t.co/RyMDXi8Y8f
@bioinfo44
0
1
1
Our paper on using human genetics to predict drug program success is out! https://t.co/klFsgx9Rpv
https://t.co/LWF7wNgbvX
journals.plos.org
Author summary The growth of human genetics resources has the potential to help us develop better drugs. By looking at whether and how historical drug approvals could have been predicted from our...
8
37
71
This is a titanic effort using GTEx data to map genome-wide gene expression in 49 tissues to 4,091 human traits. Incredible resource for precision medicine and drug target discovery.
biorxiv.org
Abstract Large-scale genomic and transcriptomic initiatives offer unprecedented ability to study the biology of complex traits and identify target genes for precision prevention or therapy. Transla...
0
6
16
Excited to share our latest work on probabilistic TWAS (PTWAS) and multi-tissue TWAS analysis utilizing GTEx v8 data https://t.co/sAdws1qyuf Great collaboration with @yuhua_z, Corbin Quick, Alvaro Barbeira, @hakyim, @fluca2406, and @rogerpique. Comments are welcome! 1/n
biorxiv.org
Transcriptome-wide association studies (TWAS), an integrative framework using expression quantitative trait loci (eQTLs) to construct proxies for gene expression, have emerged as a promising method...
1
29
68
Third traditional conference fishing trip this time in Galveston TX #ASHG2019 @rogerpique @NeBanovich @rahasesi81
2
1
22
Emily King is here in the flesh!!!check out her postdoc work. She’ll be there Thursday afternoon https://t.co/FW5yZAmuoF
#ASHG19
0
1
0
Emily King is here in the flesh!!!check out her postdoc work. She’ll be there Thursday afternoon https://t.co/FW5yZAmuoF
#ASHG19
0
1
0