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Using a 313-variant polygenic risk score (PRS), we propose risk-adapted breast cancer screening starting ages instead of a universal shift to 40 (Figure 1).

Reviewing a decade of records, South and East African men are at 3-fold greater risk for prostate cancer death than both White and Black Americans, while within Sub-Saharan Africa the impact of this disease appears to be under-estimated for East Africa.

Using a novel, hierarchical approach to ask questions about reasons for a mammogram, article authors showed self-reported reasons for mammography had good agreement with electronic health record data. @kpwaresearch

Mammographic classification of interval breast cancers reveals potential for AI to improve cancer detection at time of screening in the U.S.

This systematic review and meta-analysis found that radiation, chemotherapy, and their combination were associated with an increased risk of secondary malignancies after treatment of testicular germ cell tumors, while surgery alone was not. @moosemousa

A recent study by the American Cancer Society found that following the American Cancer Society Guideline for Cancer Survivors after diagnosis is linked to lower mortality risk among non-smoking survivors of obesity-related cancers.

DFCI, MDACC, SGK, IBC Research Foundation + the Milburn Foundation validate a new IBC web tool that helps providers accurately diagnose inflammatory breast cancer so patients don't miss out on rapid, guideline concordant care. @ibcradiation @mdandersonnews

Asian American, Pacific Islander and White solid organ transplant recipients have higher risk of multiple cancers compared w/ their race-matched general population. Risk difference could vary due to transplantation or other factors. @theNCI @TaoJunRose

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Exercise training, especially combined RT + AT, can potentially reduce pro-inflammatory biomarkers in survivors of breast cancer. Considering association between inflammation and tumor progression, exercise should be routinely integrated. @Fbettariga

hrHPV type-specific CIN2/CIN3/AIS population-based incidence decreased significantly for vaccine types HPV16/18 and for HPV31 and HPV33. However, the LT vaccine impact in cohorts receiving the 4-valent vaccine requires continued follow-up. @UNMCCC

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A @PennCancer team has defined a network of tumor-intrinsic and immune-related molecular traits that distinguish the subset of early stage HPV+ oropharyngeal cancers predisposed to fail standard therapy:. @basulab1 @PennMedicine @Penn_ENT @Penn_CBIO.

Neighborhood disadvantage associated with higher cancer risk behaviors among African Americans - Multi-level approaches to improve health equity will be required.

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Recent clinical trial results in TNBC lacked strong evidence to support using pCR as a surrogate marker for LT survival in early-stage TNBC patients at trial level. LT efficacy+safety of minimising drug approval delay must be assessed.@TYoshiMD @TFujii_MD

After adjusting for treatment selection bias, RCT overall survival and RCT radiographic progression-free survival estimates serve as useful, or even conservative, predictors of real-world overall survival gain.

According to many recent reports, colon cancer is increasing in the young. However, most of the increase can now be attributed to the reclassification of appendix NET/carcinoids. Recommendations for colon cancer screening at an earlier age may be affected.

Dynamic weight measurements in medical records of patients with advanced cancer enable early identification of those who go on to experience progressive weight loss and shorter survival. @KPCancerRsrch

LLMs show promise in supporting patient-friendly clinical trial educational materials, but human oversight is still needed @dbittermanmd.