A newly published case report in JCP presents what may be the first documented instance of a #manic episode potentially triggered by #primidone in a patient with essential tremor and a history of depression. 🔗

Rare impulse control problems associated with #aripiprazole may be overlooked. A new case series highlights two patients with prior substance use disorders who developed compulsive substance use while on aripiprazole, which resolved after discontinuation.

Developing a Clozapine Titration Monitoring Algorithm: Integration of Evidence and Clinical Experience at a University Hospital

New study of over 120,000 #clozapine therapeutic drug monitoring samples finds #smokers may need lower #plasma levels than nonsmokers for treatment-resistant #schizophrenia. Adverse drug reactions appear earlier in nonsmokers, particularly in women. 🔗

How Does Drug Company Marketing Affect Physician Prescribing?

In a new study from Mayo Clinic, EHR-derived outcomes (like antidepressant non-refill) were tested as proxies for treatment response. Findings support non-refill as a scalable, real-world measure of antidepressant tolerability. Read more in our new issue:

Childhood Bruxism Associated With Sertraline Dose Increase: A Case Report

Question: Is it safe for people with cancer and other serious conditions to combine cannabidiol with melatonin when neither has worked well enough for insomnia when used alone?

Can a patient's family history of medication response help guide treatment for mood disorders? Although this approach is widely used, a new systematic review finds that the supporting evidence is limited. 📘 Article: 🎧 Podcast:

Are doctors being subtly influenced by the pharmaceutical industry — even through e-prescribing alerts? Dr. Jeffrey Mattes’ guest editorial and podcast expose how marketing shapes clinical decisions. 🎧 Podcast: 📰 Editorial:

Our July/August 2025 issue (Volume 45, issue 4) is now available online:  Brief synopsis of the new issue from the Journal of Clinical Psychopharmacology Editor-in-Chief is below.

Developing a Clozapine Titration Monitoring Algorithm: Integration of Evidence and Clinical Experience at a University Hospital

How Does Drug Company Marketing Affect Physician Prescribing?

Childhood Bruxism Associated With Sertraline Dose Increase: A Case Report

Question: Is it safe for people with cancer and other serious conditions to combine cannabidiol with melatonin when neither has worked well enough for insomnia when used alone?

Semaglutide-Mediated Lithium Toxicity

Lumateperone for Mixed Features in MDD and Bipolar Depression: Advancing Treatment or Raising New Questions

Reply to Letter From Surekha et al: “Lumateperone for Mixed Features in MDD and Bipolar Depression: Advancing Treatment or Raising New Questions”

The Potential Benefits of Chromium and Selenium Supplementation Across Psychiatric Disorders and Symptoms

Use of Clozapine in Pregnancy: A Retrospective Study From North India