Iwase Laboratory
@Iwase_Lab
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Official account of the Iwase Lab research group @umich. We study chromatin dynamics in the brain & rare disease. PI @brainchromatin
Ann Arbor, MI
Joined December 2020
That's us 🤩 #RareDisease research is ongoing every day in our lab 🧬🧠.
The @Iwase_Lab focuses on how regulation of chromatin, the bundle of DNA and proteins that make up chromosomes, influences brain development & function. They study primarily 3 rare disorders: KDM5C disorder, Smith-Magenis syndrome, and Potocki Shaffer syndrome. #ShowYourStripes
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This work was lead by PhD candidate Cecilia Gavilan, with contributions from multiple Iwase lab members. Check it out online!
pubmed.ncbi.nlm.nih.gov
PHF21A is a histone reader protein that recognizes unmethylated H3 lysine 4 and binds to DNA through its AT-hook motif. PHF21A heterozygosity is associated with intellectual disability, behavioral...
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New paper alert! 📣 A #PHF21A variant reduces splicing efficiency of PHF21A isoforms while maintaining DNA binding capability. Reduced dosage rather than impaired DNA binding likely contributes to the cognitive impairments seen in the individual with this variant.
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RT @WebsEdge_Med: Whether it's engaging the member community within @GeneticsSociety or educating the public about the benefits of human ge….
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Iwase lab is ready for race weekend! 🧬👟.This important fundraising event by @KaresFoundation supports #KDM5C families & research.
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RT @KaresFoundation: Hurry, only 1 week left to register for the KARES 5K AND get your t-shirt and swag! Register at .
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RT @KaresFoundation: 🔬✨ Exciting news! The KARES Foundation is now accepting 2024 research grant applications. Up to $30,000 available for….
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We've been attending the @smsprisms annual conference for Smith-Magenis Syndrome. Thank you for hosting this meeting bringing together the #SMS community. What a privilege to meet Dr. Smith who discovered #SMS and Ms. Schmitt the president of the French #SMS society ASM17.
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RT @smsprisms: Early intervention can be key for individuals with SMS. PRISMS has pulled together resources to help you navigate Early Inte….
prisms.org
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New mechanistic insight into how #KDM5C variants lead to intellectual disability phenotypes from our collaborator and former mentor Dr. Yang Shi.
Researchers from @Ludwig_Cancer Oxford and @BostonChildrens find clues to help treat intellectual disabilities linked to KDM5C gene mutations. Understanding how Wnt affects memory formation may lead to new #CognitiveDysfunction therapies 🧠. Read more 👉
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Our latest work on #LSD1 is out as a preprint. Former postdoc Dr. Masayoshi Nagai describes the temporal effects of neuron-specific microexon splicing on enzymatic activity of LSD1.
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Thank you @KaresFoundation for organizing the FIRST EVER #KDM5C Family & Science Conference. What a special opportunity to connect with KDM5C families, as well as fellow researchers & clinicians.
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🥳 first of many! #KDM5C #RareDisease.
That’s a wrap on our inaugural KARES Family & Science Conference! Thank you to all of our attendees, presenters, volunteers, and especially to the Conference Planning Committee for making this wonderful weekend possible. 💜
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Meet our #KDM5C UofM ✨dream team✨: PhD student Ilakkya, Dr. Shigeki Iwase, Dr. Katy Keegan, & Dr. Kristen Lee from @UM_Genetics @umichmedicine. We are at the KDM5C Family & Science Conference hosted by @KaresFoundation ~ connecting with researchers, clinicians, & families 🤓🧬
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RT @KaresFoundation: We have accomplished so much over the last year! . Check out our 2023-2024 Annual Report, to see some of all the amazi….
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This year's #KDM5C awareness day was extra special as we prepped to attend the FIRST KDM5C conference this weekend put on by @KaresFoundation. Congrats to KARES for all you've accomplished in this last year, supporting families & research!.
It's our 2nd annual #KDM5C Awareness Day! Today we celebrate how much we've grown in our first full year as a nonprofit patient advocacy group. 🥳. Check out our full annual report at 💜
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