The Hepatitis B vaccine is one of the cheapest, most cost-effective medical interventions ever developed. A full 3-dose series for an infant typically costs $10–30 globally (even less in some programs). Now compare that to the cost of not vaccinating…
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2/If someone becomes chronically infected with Hep B, the cost burden is enormous. Chronic HBV requires lifelong monitoring, repeat lab tests, antiviral therapy, liver imaging, and sometimes hospitalization. Annual medical costs average $3,000–$6,000/year in high-income countries
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3/ Antiviral medications alone (e.g., tenofovir, entecavir) can cost $300–$1,200 per year depending on the country and insurance. Since therapy is often lifelong, the cost quickly exceeds tens of thousands of dollars per patient.
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4/ Chronic Hep B leads to cirrhosis or liver cancer in 15–40% of patients. Treating these complications is expensive: • Liver cancer care routinely reaches $50,000–$200,000+ • A liver transplant? Typically $500,000–$1,000,000 including post-operative care.
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5/ When you add it all up, the lifetime cost of chronic Hepatitis B infection in the U.S. is often estimated at $200,000–$500,000 per patient, and can exceed $1 million if advanced liver disease develops. Compare that to a vaccine that costs less than dinner.
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6/ Economists call Hep B vaccination a “high-value intervention.” Every dollar spent on Hep B vaccines saves more than $10–20 in avoided medical costs, depending on the model. This is before you even account for productivity, disability, or lost income.
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7/ So yes—Hep B vaccination is cheap. What’s expensive? Lifelong antiviral therapy, liver scans, biopsies, hospitalizations, and transplants. Preventing a chronic, cancer-causing virus for $10–30 is one of the best deals in public health history.
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