Herbison Lab
@HerbiLab
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Our focus is understanding the mechanisms by which neurons in the brain control fertility - #neuroendocrinology #neuroscience #fertility #GnRH #hypothalamus
University of Cambridge
Joined May 2020
Noradrenergic control of the kisspeptin pulse generator now out at Nature Comms.
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New book on Evolutionary Neuroendocrinology now out - including a chapter on the GnRH neuron. Evolutionary and Comparative Neuroendocrinology.©2025XIV, 494 p. 98 illus., 92 illus. in color.
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In vivo recordings of GnRH neurons now available to download.
elifesciences.org
The gonadotropin-releasing hormone (GnRH) neurons controlling fertility exhibit abrupt increases in activity to generate luteinizing hormone (LH) pulses and a sustained oscillatory pattern of...
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Oh dear. what is wrong with my PCOS mouse model?.
elifesciences.org
Common mouse models of polycystic ovary syndrome (PCOS) have variable ability to recapitulate the increased GnRH pulse generator frequency thought to exist in women with PCOS.
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When Machine Learning meets the Pulse Generator.
academic.oup.com
Abstract. The arcuate nucleus kisspeptin (ARNKISS) neurons represent the GnRH pulse generator that likely drives pulsatile gonadotropin secretion in all ma
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Next up: the *female* #GnRH pulse generator. presenting our latest on the mechanism of ARN #kisspeptin neuron synchronization:. #fertility.
academic.oup.com
Abstract. The mechanism by which arcuate kisspeptin (ARNKISS) neurons co-expressing glutamate, neurokinin B, and dynorphin intermittently synchronize their
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Latest CRISPR offering from Herbi lab has finally arrived as "Version of Record" on Elife platform. Happy holidays everyone! .
elifesciences.org
Preoptic area neurons co-expressing GABA and kisspeptin are essential for the preovulatory surge mechanism but not for the pulsatile secretion of luteinizing hormone.
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You probably thought that estradiol levels peaked at proestrus in mice.
academic.oup.com
Abstract. Despite the importance of the mouse in biomedical research, the levels of circulating gonadal steroids across the estrous cycle are not establish
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Before we get lynched by the kisspeptin community. GABA-B is the inhibitory counterpart to the critical stimulatory effect of kisspeptin 😀. GABA-A is disappointing - see paper.
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Latest from HerbiLab. Thanks for the ride "KNDy hypothesis" but now its R.I.P.!.
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Latest offering from the HerbiLab. Many, many, years in the making and especially huge efforts from the two first authors Jamie and Jenny.
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RT @Navarro_Lab_: Here it is! Join us for the next virtual kisspeptin+ meeting. Program and information on abstract submission in the link.….
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If you are interested in KNDy neurons, how they control the GnRH neuron dendron and Dale's Hypothesis check out our latest publication .
elifesciences.org
The arcuate nucleus kisspeptin neurons express multiple transmitters but use only the neuropeptide kisspeptin to drive the episodic secretion of gonadotropin-releasing hormone.
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Can we finally put the RFRP/GnIH fiasco to bed! See recent JN paper from Anderson lab Essentially NO effects of DMH & RFRP3 neuron ablation or chronic activation on puberty, estrous cycles, LH pulses or fertility.
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