HenleyLab
@Henley_Lab
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Henley Lab in @bristolbiochem at @bristoluni.
Bristol
Joined May 2024
Excited to share our new preprint by @NitheyaaS🥳showing that PINK1 undergoes SUMOylation and exploring its role in regulating basal mitophagy.
biorxiv.org
The detection and removal of damaged mitochondria is essential for cells to maintain a healthy mitochondrial network. PTEN-induced kinase 1 (PINK1) is a critical sensor that detects mitochondrial...
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It was a valuable opportunity to engage with leading researchers and exchange insights in the field of neurochemistry. We thank the organizers for an excellent meeting and express our appreciation for the travel grants.
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We attended the European Society for Neurochemistry ESN-HSN meeting held in Naxos, Greece, from May 18-21. The conference featured outstanding scientific presentations, including a keynote lecture by Nobel Prize winner Thomas Südhof.
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RT @NitheyaaS: Excited to share this amazing story, identifying SUMOylation of MFF as a key regulator in promoting stress-induced mitochond….
science.org
A key molecular step is identified for the fragmentation and removal of damaged mitochondria that is essential for cell health.
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RT @J_Cell_Sci: Our next highlighted researcher for Postdoc Appreciation Week #NPAW24 is Alexandra Fletcher-Jones, @Henley_Lab. Alexandra’s….
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New paper alert! A fantastic protocol paper in collaboration with @busrapyucel and @kevwilkinson. Protocol for detecting palmitoylation of high-molecular-weight rat syn.
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So excited that one of my images is the cover of the current issue of the Journal of Cell Science! -Alex.
Issue 11 is complete!.Explore our ToC: Our cover image shows a primary hippocampal neuron transfected with EGFP–CB1R (green); surface EGFP–CB1R (magenta) is restricted to the axon. Untransfected neurons are labelled with MAP2 (blue).
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RT @J_Cell_Sci: Issue 11 is complete!.Explore our ToC: Our cover image shows a primary hippocampal neuron transfect….
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RT @J_Cell_Sci: Find out more about this research in our ‘First person’ interview with Alexandra Fletcher-Jones: ht….
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RT @J_Cell_Sci: Alexandra Fletcher-Jones, Jeremy Henley @Henley_Lab and colleagues @BristolUni find that SGIP1 binding to the α-helical H9….
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SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression
journals.biologists.com
Summary: The cannabinoid type 1 receptor is stabilised at the axonal surface through interaction of its intracellular helix 9 domain with the endocytic adaptor protein SGIP1.
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