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Molecular Instruments

@HCRimaging

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Inventors of HCR, protease-free RNA-ISH, and the game-changing HiFi Encoder for multiplex IF

Los Angeles, CA
Joined March 2018
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@HCRimaging
Molecular Instruments
3 days
Happy Halloween from the MI team! Check out this spooky-themed rat hippocampus image by Jamuna Tandukar using #HCRimaging. 🧠 🟣 Mettl3 ⚪️ astrocytes 🟢 nuclei 🟠 rRNA
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@HCRimaging
Molecular Instruments
10 days
#onlywithHCR: How do complex structures like gill slits form during early development? Gillis et al. were able to use #HCRtechnology to visualize gene expression during gill slit formation in skate embryos, revealing a precise sequence of epithelial interactions between the
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@HCRimaging
Molecular Instruments
12 days
Goodbye secondaries. Hello Encoder. Off-the-shelf antibody panels lock you into fixed menus and rigid workflows. The HCR™ HiFi Encoder changes the game, giving you the power to encode any unmodified primary in just 10 minutes at room temperature. Use your existing antibodies,
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@HCRimaging
Molecular Instruments
13 days
We’re proud to partner with @abcam to make multiplex IF simpler, faster, and more flexible! The HCR™ HiFi Encoder offers broad compatibility with Abcam’s primary antibodies, bringing high-performance, quantitative, HCR™ Gold amplification to the antibodies you already know and
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@HCRimaging
Molecular Instruments
17 days
#onlywithHCR: In a fascinating new study, Rajan et al. illuminated how multicellular dynamics shape olfactory neurogenesis in zebrafish, offering insights relevant to vertebrate sensory systems. The researchers found that mutually antagonistic Notch/Insm1a signaling governed
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@HCRimaging
Molecular Instruments
21 days
🚀 The HCR™ HiFi Encoder has officially launched, bringing plug-and-play practicality to multiplex IF. With the Encoder, you can: ✅ Confidently multiplex same-species primaries with zero cross-reactivity ✅ Encode unmodified primary antibodies in 10 minutes at RT without
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@HCRimaging
Molecular Instruments
24 days
#onlywithHCR: @AdRoMora and @rkmille in the @McGovernPeds department at @McGovernMed, together with Alejandra Davilavaladez (who contributed through her MS thesis project in the @UTGSBSGnE program at @MDA_UTHGrad), investigated how pathogenic TP53 variants, known for driving
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@HCRimaging
Molecular Instruments
25 days
Episode 2 of the HCR™ HiFi Encoder series is now live! This time, we’re walking through the entire encoding protocol from start to finish. See just how easy it is to integrate into your workflow: no purification, no conjugation, only 10 minutes at room temperature. Learn how
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@HCRimaging
Molecular Instruments
26 days
Check out this stunning whole-mount fruit fly image from Dr. Nipam Patel and Saanvi Turki at the @MBLScience, powered by the HCR™ HiFi Encoder. With the Encoder, you can functionalize any unmodified primary antibody with no purification, no reformulation, and no signal loss.
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@HCRimaging
Molecular Instruments
28 days
#BehindMI: Every smooth update and successful product launch is driven by a team committed to innovation and reliability. Meet Mohamad and Jawad, two of the software engineers driving MI's digital infrastructure forward. From developing robust software to tackling complex
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@HCRimaging
Molecular Instruments
1 month
#onlywithHCR: What happens in the brain when an animal freezes in fear? Bhandiwad et al. used #HCRtechnology to map neural activity underlying tonic immobility. A strong vibratory stimulus triggers tonic immobility in larval zebrafish, characterized by halted locomotion and
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@HCRimaging
Molecular Instruments
1 month
Stop by Booth #630 and meet the MI team at the @NS4Histotech's #2025NSHConvention in Long Beach this weekend! Join our Director of Associate Marketing, Joyce Yoo, and @Indica_Labs's Associate Product Manager, Emily Gamble, for a workshop with Indica Labs to see how HCR™ Pro
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@HCRimaging
Molecular Instruments
1 month
Take a look at this FFPE mouse brain sample demonstrating true same-species multiplexing with four rabbit IgG antibodies, made possible with the HCR™ HiFi Encoder! With the Encoder, you can detect multiple same-species primaries in parallel with no cross-reactivity, no complex
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@HCRimaging
Molecular Instruments
1 month
#onlywithHCR: An interesting study by Monroy et al. leveraged #HCRtechnology to visualize mRNA expression of key transcription factors, revealing the timing and localization of neural crest (NC) development in chicken, quail, and peafowl. They found that while expression
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@HCRimaging
Molecular Instruments
2 months
Get your first look inside the tech that's redefining the future of multiplex IF. In this premiere episode, we introduce the HCR™ HiFi Encoder – a powerful new tool that lets you rapidly encode any unmodified primary antibody in just minutes. Say goodbye to fixed antibody
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@HCRimaging
Molecular Instruments
2 months
📢Short RNA target detection is now powered by HCR™ Pro RNA-ISH on the @LeicaBio BOND RX research staining platforms! HCR™ HiFi Probe architecture has been expanded to support short RNA targets, bringing the same clinical-grade background suppression that users rely on from
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@HCRimaging
Molecular Instruments
2 months
#onlywithHCR: Zic5 Tunes Hedgehog Signaling for Eye Development 👁️ How do transcription factors fine-tune signaling pathways during organogenesis? A study by Sun et al. uncovered a pivotal role for Zic5 in Xenopus eye development. Specifically, using #HCRtechnology, the team
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@HCRimaging
Molecular Instruments
2 months
🚀 Introducing the HCR™ HiFi Encoder We're excited to announce the upcoming launch of the HCR™ HiFi Encoder, a breakthrough in multiplex immunofluorescence (IF)!The HiFi Encoder makes it possible to: ✅ Encode unmodified primary antibodies without affecting target-binding
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@HCRimaging
Molecular Instruments
2 months
#BehindMI: Meet some of the members of our Admin team, powering the engine behind the scenes at MI! From processing purchase orders and sending invoices to maintaining our systems and keeping records up to date, they ensure our mission runs smoothly and the HCR™ community
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