Molecular Instruments
@HCRimaging
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Inventors of HCR, protease-free RNA-ISH, and the game-changing HiFi Encoder for multiplex IF
Los Angeles, CA
Joined March 2018
Happy Halloween from the MI team! Check out this spooky-themed rat hippocampus image by Jamuna Tandukar using #HCRimaging. 🧠 🟣 Mettl3 ⚪️ astrocytes 🟢 nuclei 🟠 rRNA
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#onlywithHCR: How do complex structures like gill slits form during early development? Gillis et al. were able to use #HCRtechnology to visualize gene expression during gill slit formation in skate embryos, revealing a precise sequence of epithelial interactions between the
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Goodbye secondaries. Hello Encoder. Off-the-shelf antibody panels lock you into fixed menus and rigid workflows. The HCR™ HiFi Encoder changes the game, giving you the power to encode any unmodified primary in just 10 minutes at room temperature. Use your existing antibodies,
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We’re proud to partner with @abcam to make multiplex IF simpler, faster, and more flexible! The HCR™ HiFi Encoder offers broad compatibility with Abcam’s primary antibodies, bringing high-performance, quantitative, HCR™ Gold amplification to the antibodies you already know and
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#onlywithHCR: In a fascinating new study, Rajan et al. illuminated how multicellular dynamics shape olfactory neurogenesis in zebrafish, offering insights relevant to vertebrate sensory systems. The researchers found that mutually antagonistic Notch/Insm1a signaling governed
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🚀 The HCR™ HiFi Encoder has officially launched, bringing plug-and-play practicality to multiplex IF. With the Encoder, you can: ✅ Confidently multiplex same-species primaries with zero cross-reactivity ✅ Encode unmodified primary antibodies in 10 minutes at RT without
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#onlywithHCR: @AdRoMora and @rkmille in the @McGovernPeds department at @McGovernMed, together with Alejandra Davilavaladez (who contributed through her MS thesis project in the @UTGSBSGnE program at @MDA_UTHGrad), investigated how pathogenic TP53 variants, known for driving
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Episode 2 of the HCR™ HiFi Encoder series is now live! This time, we’re walking through the entire encoding protocol from start to finish. See just how easy it is to integrate into your workflow: no purification, no conjugation, only 10 minutes at room temperature. Learn how
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Check out this stunning whole-mount fruit fly image from Dr. Nipam Patel and Saanvi Turki at the @MBLScience, powered by the HCR™ HiFi Encoder. With the Encoder, you can functionalize any unmodified primary antibody with no purification, no reformulation, and no signal loss.
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#BehindMI: Every smooth update and successful product launch is driven by a team committed to innovation and reliability. Meet Mohamad and Jawad, two of the software engineers driving MI's digital infrastructure forward. From developing robust software to tackling complex
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#onlywithHCR: What happens in the brain when an animal freezes in fear? Bhandiwad et al. used #HCRtechnology to map neural activity underlying tonic immobility. A strong vibratory stimulus triggers tonic immobility in larval zebrafish, characterized by halted locomotion and
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Stop by Booth #630 and meet the MI team at the @NS4Histotech's #2025NSHConvention in Long Beach this weekend! Join our Director of Associate Marketing, Joyce Yoo, and @Indica_Labs's Associate Product Manager, Emily Gamble, for a workshop with Indica Labs to see how HCR™ Pro
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Take a look at this FFPE mouse brain sample demonstrating true same-species multiplexing with four rabbit IgG antibodies, made possible with the HCR™ HiFi Encoder! With the Encoder, you can detect multiple same-species primaries in parallel with no cross-reactivity, no complex
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#onlywithHCR: An interesting study by Monroy et al. leveraged #HCRtechnology to visualize mRNA expression of key transcription factors, revealing the timing and localization of neural crest (NC) development in chicken, quail, and peafowl. They found that while expression
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Get your first look inside the tech that's redefining the future of multiplex IF. In this premiere episode, we introduce the HCR™ HiFi Encoder – a powerful new tool that lets you rapidly encode any unmodified primary antibody in just minutes. Say goodbye to fixed antibody
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📢Short RNA target detection is now powered by HCR™ Pro RNA-ISH on the @LeicaBio BOND RX research staining platforms! HCR™ HiFi Probe architecture has been expanded to support short RNA targets, bringing the same clinical-grade background suppression that users rely on from
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#onlywithHCR: Zic5 Tunes Hedgehog Signaling for Eye Development 👁️ How do transcription factors fine-tune signaling pathways during organogenesis? A study by Sun et al. uncovered a pivotal role for Zic5 in Xenopus eye development. Specifically, using #HCRtechnology, the team
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🚀 Introducing the HCR™ HiFi Encoder We're excited to announce the upcoming launch of the HCR™ HiFi Encoder, a breakthrough in multiplex immunofluorescence (IF)!The HiFi Encoder makes it possible to: ✅ Encode unmodified primary antibodies without affecting target-binding
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#BehindMI: Meet some of the members of our Admin team, powering the engine behind the scenes at MI! From processing purchase orders and sending invoices to maintaining our systems and keeping records up to date, they ensure our mission runs smoothly and the HCR™ community
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