INHALE WP3 RCT health economic analysis now published in Critical Care. The Pneumonia Panel PCR had lower average ICU costs and was cost effective for antimicrobial stewardship, but not clinical cure. Read in full at:

'INHALE Poem II – A slight diversion’ shares the journey of INHALE, describing its hopes, challenges and implications of the research. This poem was written and performed by Amander Wellings, of the INHALE Patient, Carer and Public Involvement (PPI) group https://t.co/pqvCPITd2I

What is the impact of seeking pathogens by rapid molecular diagnostic methods on antibiotic stewardship and the clinical outcomes in hospital-acquired and ventilator-associated pneumonia? Visual abstract below and full paper available online at https://t.co/Knni5CnP50

INHALE compared rapid testing with standard care used to diagnose pneumonia in intensive care. Rapid testing gave faster results than standard care and improvements in antibiotic use. But, the machine did not improve cure of pneumonia, so more research is needed to understand why

4/4 "Guidelines vs mindlines: A qualitative investigation of how clinicians' beliefs influence the application of rapid molecular diagnostics in intensive care", published in Antimicrobial Agents and Chemotherapy is now available. https://t.co/halUO5zRmx

3/4 Implementation strategies for technological solutions to antimicrobial resistance must be ‘behaviourally intelligent’, recognising the challenges facing clinicians when making ‘life or death’ prescribing decisions.

2/4 limiting application of these tests in practice. Findings underscore the challenge of changing prescribing decisions based on technical results, or guidelines, highlighting factors such as clinicians’ previous experience and ‘knowledge in practice, to be more proximal drivers

1/4 Rapid molecular diagnostic tests for pathogens and resistance genes may improve antibiotic prescribing decisions and stewardship. However, clinicians’ desire to protect their patient with an antibiotic often overrides more distal concerns about possible resistance selection,

1/2 The INHALE WP3 randomised trial provides multi-centre evidence that rapid syndromic PCR, delivered at the point-of care in the ICU improved antibiotic stewardship by 21% in absolute terms. Equivalence of clinical cure was not demonstrated.

We’re expanding our reach! Follow us on: Bluesky: @ https://t.co/TVe3NVeyWB LinkedIn: INHALE trial ( https://t.co/UeYz302Xk7) For all of the latest news from INHALE.

Flexible job opportunity! We're seeking a research associate to work on the @HAP_Diagnostics project. Mainly analyses & data collection. Ideal candidate would have knowledge of microbiology and antimicrobials. Would suit recent graduate or similar. https://t.co/FNFoie9n9u

Great to be in sunny (but very windy) Cascais for #EHPS2024. Looking forward to presenting some of our work from @HAP_Diagnostics on Thursday!! ☀️

Our latest paper - exploring clinician prescribing behaviour in icu during the covid pandemic.

Excited to share our latest paper from the INHALE research programme @HAP_Diagnostics exploring prescribers' attitudes towards using rapid molecular diagnostic technology to guide antibiotic prescribing in ICU patients with pneumonias - open access link:

Fascinating results from Dagfunn Markussen demonstrating that “high quality” and “low quality” respiratory samples showed no difference in detection of common pneumonia pathogens in CAP patients. #eccmid2023

Don’t miss INHALE RCT trial results of POCT multiplex pneumonia PCR presented by @Beat_AMR_Bugs today at 16:15 in Hall P. #ECCMID2023

Don’t miss INHALE RCT trial results of POCT multiplex pneumonia PCR presented by @Beat_AMR_Bugs today at 16:15 in Hall P. #ECCMID2023

Rob Horne: One major finding of our behaviour work was that clinicians do not sufficiently consider the immediate harms of broad-spectrum antibiotics. Future antibiotic stewardship interventions should focus on this. #eccmid2023

80% of clinicians believed molecular diagnostics but concerns such as fears of patient deterioration drove non-adherence to both the trial prescribing algorithm and hospital guidelines.

Our #healthec analysis shows ICU costs for participants in PCR intervention arm were lower in all scenarios analysed, Those in the @BioFireDX Pneumonia Panel arm had an average saving of £9,940 for the ICU stay.