
Sarah Goetz
@GoetzLab
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Embryo aficionado, ciliavangelist. Associate professor at Duke University School of Medicine. Tweets and opinions are my own. She/her.
Durham, NC
Joined August 2018
Excellent work, Carolyn! So glad this is finally out!.
New research led by Carolyn Ott, a senior scientist @JLS_Lab, provides the most detailed & comprehensive description yet of cilia in the mouse visual cortex, giving scientists new insights into the formation & function of this small & elusive organelle. 🔗
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This was the work of @LoukilLab when he was a postdoc in my lab, former technician Emma Ebright, and our collaborators in @SoderlingLab.
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I'm excited to have this manuscript out!.In vivo BioID to label cilia and identify new components of cilia in neurons. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders
biorxiv.org
Primary cilia are conserved sensory hubs essential for signaling transduction and embryonic development. Ciliary dysfunction causes a variety of developmental syndromes with neurological features and...
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This thread is spot on. What is worse is that some institutions made repeated assurances that no really, they understood what we were dealing with and it would *definitely* not be forgotten when it was time for tenure and promotion. I hoped, rather than believed, it was true 😔.
This isn't a new thought, but I'm wondering today how much of the pervasive sense of burnout or disengagement among life science professors today is a sense of soft institutional betrayal for the last three years. That our institutions do not share our morals.
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New preprint from my lab where we present unexpected findings that human ataxia-associated variants of TTBK2 mis-localize to peroxisomes! There they interfere with peroxisome-mediated trafficking of membrane proteins to cilia.
biorxiv.org
Frameshift mutations in Tau Tubulin Kinase 2 ( TTBK2 ) cause spinocerebellar ataxia type 11 (SCA11), which is characterized by the progressive loss of Purkinje cells and cerebellar atrophy. Previous...
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Happy to be here at #CellBio2022 after 3 years! And very happy to have turned in my tenure materials so I can actually think about other things again!.
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