Ovarian cancer has the worst prognosis among major gynecological cancers. Current therapies include platinum, Taxol, angiogenesis inhibitors, and poly[ADP-ri...

IntroductionMutations in the DDX3X gene are the primary cause of DDX3X syndrome, with over 800 diagnosed families worldwide. DDX3X is also recognized as a si...

BackgroundRosacea is a chronic inflammatory skin disease characterized by vascular and neurological dysregulation, presenting with diverse clinical subtypes ...

Turner syndrome (TS) arises from partial or complete loss of a sex chromosome, yet the mechanistic basis for Y chromosome loss (LoY), which may contribute to...

Oxidative mechanisms were further explored, through innovative experimental models, at the molecular and cellular level, in the study by Cao et al. who inves...

Ribonucleotide modifications modulate RNA structure and stability, thereby influencing RNA turnover and a wide range of cellular functions. Recent studies ha...

Humans and laboratory animals differ in their resistance to hypoxia, which affects the severity of inflammatory diseases and the rate of tumor progression. T...

Building upon our previous work on drug repurposing and the use of binary combinations as anti-Chagas agents, we detail our efforts to advance the most promi...

Cold plasma (CP) treatment has emerged as a promising green processing technology for enhancing the quality of tobacco by modifying its physical structure an...

BackgroundIn the present study, lysozyme was analyzed in the nanoparticle Venetin-1 obtained from the coelomic fluid (CF) of the earthworm Dendrobaena veneta...

Autophagy is an evolutionarily conserved catabolic process that plays a central role in maintaining cellular homeostasis by degrading and recycling damaged o...

IntroductionAdenine nucleotide translocase (ANT), phosphate translocase (PiT), and uncoupling proteins (UCPs), all integral to oxidative phosphorylation, are...

IntroductionColorectal cancer (CRC) is one of the leading causes of cancer-related death, and most CRCs arise from colorectal adenomas. Early detection and r...

Black poplar is a woody species rich in bioactive phenolic compounds with promising pharmaceutical and cosmetic applications. In wild populations, genetic di...

Living systems perform chemical transformations under conditions and with precision that synthetic chemistry cannot reach. As such, the field has increasingl...

IntroductionBehavioral interventions for autism spectrum disorder show variable outcomes, highlighting the need for complementary therapies. Music-based inte...

BackgroundSOX2 and LPCAT1 are implicated in tumor progression, but their roles in osteosarcoma pathogenesis and cholesterol metabolism remain unclear.MethodS...

ObjectiveDespite advances in EGFR-TKIs for lung adenocarcinoma (LUAD), resistance remains a major hurdle. This study aimed to develop a prognostic model inte...

Many individuals with chronic, medically unexplained symptoms remain without a diagnosis, despite extensive clinical evaluations. Here, we present a framewor...

Mechanistic modeling in biology aims to describe biological processes based on details on molecular mechanisms and interactions. Rule-based mechanistic model...