To help research during this challenging time, FlowJEM is offering price discounts on our products. We offer DropSeq, DroNc, and inDrop PDMS microfluidic devices for RNA sequencing for SARS-CoV-2 diagnostics, therapeutics and vaccine development . .

Read about the impact of integration in #microfluidics-based #organ-on-a-chip technologies on #drug design and biochemical #sensing in the review paper published in Biosensors.

To address the high failure rates in clinical drug trials for Alzheimer’s and Parkinson’s diseases, organ-on-a-chip platforms offer a promising tool, due to their ability to mimic human-specific tissue niches in vitro. Read the review by Kamm et al.

Recent advances in #Organ-on-a-Chip models highlight integration of precision engineering and cutting edge technologies in #microfabrication for the development of preclinical therapeutic models. See

A #microfluidic device fabricated by #FlowJEM was used to perform a single-cell #transcriptomic study of brain and blood cells after #ischemic stroke. Phenotypic diversification occurred within the brain in the early and recovery phases of ischemic stroke.

Interactions between #endothelial cells and the #immune environment in the #heart after #myocardial #infarction are poorly understood. FlowJEM #microfluidic devices helped to identify #immune regulatory gene signature in #heart failure tissues.

FlowJEM #microfluidic devices were used to generate a genetic #medulloblastoma #model. Inactivating AMPK depleted #tumor #stem cells and slowed down tumor progression. iScience . 2023:108443. doi: 10.1016/j.isci.2023.108443.

#SERS imaging may provide enhanced #Raman signals of cells or biomolecules and be adapted to portable systems used in POC. Read a review on combining #MFs platforms with SERS for POC analysis of #proteins, #biomarkers and #pathogens.

Human #organ-on-a-chip platforms for #disease modeling, #drug development and screening, and #personalized therapies are gaining momentum! Read review at

Timely intervention of preventative and therapeutic measures abated a 2022 monkeypox global outbreak. The potentials of human #skin-on-a-chip as a valuable model for #mpox disease evaluation are discussed by Abaci et al. at

As collagen #fiber alignment is a sign of pathological #scarring and #fibrosis, an approach to collagen matrices with controlled fibril alignment was developed using #3D printed inclined surfaces to study fibroblast behavior to reveal scar progression.

The review on complex in vitro cell culture stresses the importance of fluid flow, as illustrated by #organ on a chip #microfluidic liver models, and stresses economic benefits of more accurate models for drug toxicity (doi: 10.3389/ftox.2023.1170193).

Patterns on a #master Si wafer fabricated by FlowJEM were used to make #polydimethylsiloxane stamps for #microcontact printing to study truncation mutations in cardiac myosin binding protein C. Read J Gen Physiol (2023) 155 (4): e202213204.

FlowJEM #microfluidic devices have been used to show that inflammation in osteoarthritis patients affects differently bone and muscle endothelial cells, suggesting increased angiogenesis in subchondral bone. Read in Communications Biology.

Efficiency and cost of #pharmaceutical analysis can be improved by using #organonachip and #organoidsonchips platforms. Read about #microfluidic platforms for drug screening at

A Drop-Seq #MF device fabricated by FlowJEM enabled #single-cell #RNA sequencing that allowed for the transcriptomic profiling of a sample tissue with single-cell resolution.

Read Expert Opinion about latest models for the discovery and development of rheumatoid arthritis drugs using #2D/3D cell culture models, liquid bioreactors, and complex #joint-on-a-chip devices.

The developing lung #metastatic niche in a model of #metastatic, triple-negative #breast cancer was dissected using #single-cell RNA-sequencing using #microfluidic devices fabricated by FlowJEM. Read

#Microfabrication of #microfluidic devices by FlowJEM enabled #extraction of high-quality RNA rapidly and simply from a small quantity of blood, thus, making this process more accessible.

RT @EKumachevaGroup: 📢#2021EKGHighlight 🔥🔥🔥.This year, our microfluidics team published a series of works on developing microarray-based sp….

#Microfluidic blood-brain barrier (BBB) models, evolved from #tissue engineering and #microfabrication technology, facilitate biomedical research and drug discovery by recapitulating the complexity of the human BBB in vitro.