Flaherty Lab
@FlahertyLab
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Lab of Daniel Flaherty, Ph.D. Associate Professor of Medicinal Chemistry and Molecular Pharmacology at Purdue University.
West Lafayette, IN
Joined August 2015
First author J. Med. Chem. paper released and defending your PhD on the same day?! That’s a great day @Katrina_Holly98! Very proud of our newly minted PhD from the lab!
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New paper out today from @Katrina_Holly98 and Prabhakara Rao Tharra on their work on development of bacterial carbonic anhydrase inhibitors against vancomycin-resistant Enterococci. They produced an analog with oral efficacy rescuing mice in a septicemic peritonitis model.
Bacterial carbonic anhydrase inhibitors with improved PK and efficacy in VRE septicemia mouse model. #JMedChem @flahertylab @DrugDiscoveryPU @Purdue_MCMP
https://t.co/ZFUkOLWs6w
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So proud of @Purdue_MCMP and @FlahertyLab grad student @molly_youse for successfully defending her PhD today! She did an amazing job and we are super excited for her next steps in her scientific career!
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Very proud of @Purdue_MCMP grad student and lab member @molly_youse for being awarded the Jenkins-Knevel Award for Outstanding Graduate Research! This is the highest honor in the Purdue COP for grad research. Very well deserved!
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Design strategy from @FlahertyLab yields improved solubility for AC1 inhibitors with in vivo efficacy in rat model for inflammatory pain. #JMedChem
https://t.co/5I3kKUXM7q
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Our postdoc position is still open! #malaria #ubiquitin #proteasome #protein degradation #UPR #artemisinin #resistance #drug resistance
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This project in collab with Dr. Val Watts and @Purdue_MCMP grad student @tiffany_summerr has gone from hit identification to through two manuscripts. The current scaffold had solubility liabilities and we took an approach to break up the molecular planarity to improve solubility
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Our newest paper led by Dr. Shri Annadka presenting modifications on the pyrimidinone scaffold to improve solubility and AC1 inhibition with a new lead molecule with efficacy in a rat model for inflammatory pain. https://t.co/qHklMmWCyf
pubs.acs.org
Adenylyl cyclase isoform 1 (AC1) is considered a promising target for treating inflammatory pain. Our group identified the pyrazolyl-pyrimidinone scaffold as potent and selective inhibitors of...
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New ethoxzolamide analogs from @FlahertyLab show improved PK properties and efficacy in mouse model for gonococcal infection. #JMedChem
https://t.co/ZpznFCDKLl
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Our new paper from @Purdue_MCMP grad student @molly_youse is out. Molly designed new analogs of Ethoxzolamide with improved PK properties and anti-gonococcal activity leading to molecules with oral efficacy in a mouse model for N. gonorrhoeae infection. https://t.co/ITj2cwCcTn
pubs.acs.org
Drug-resistant gonorrhea is caused by the bacterial pathogen Neisseria gonorrhoeae, for which there is no recommended oral treatment. We have demonstrated that the FDA-approved human carbonic...
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New paper from the lab led by @Purdue_MCMP grad student @Katrina_Holly98 in collab with Groshong lab at NIAID Rocky Mountain Laboratories. Targeting the oligopeptide transport system in B. burgdorferi. https://t.co/Ge1LgpxV2E
frontiersin.org
Recent reports from the CDC approximate 500,000 cases of Lyme disease in the United States yearly, a significant economic burden on the healthcare system. St...
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Covalent UCHL1 inhibitor with crystal structure and anti-metastatic properties from @FlahertyLab @WendtLab_Cancer @KesslerlabOx Read in #JMedChem here ➡ https://t.co/JDA18mA04T
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New paper from the lab covalently targeting UCHL1. Great collab with @WendtLab_cancer @kesslerlabox and Das Lab @ClydeDadChitta! Screening, med chem, crystallography, Ub-proteomics, cellular activity all come together to tell the story. @Purdue_MCMP
https://t.co/Rpb4llYIdE
pubs.acs.org
Dysregulation of the ubiquitin-proteasome systems is a hallmark of various disease states including neurodegenerative diseases and cancer. Ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitinat...
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Purdue @Purdue_MCMP grad student @molly_youse was awarded 1st Place in the Poster Competition at the 2nd Annual Antimicrobial Resistance Conference for her work in lead opt/studying small molecule properties that affect accumulation in Neisseria gonorrhoeae! Congrats!
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I am honored to receive this title. Thank you to Chip and Jane Rutledge and to @purduepharmacy for the support!
Chip and Jane Rutledge have a history of impactful service to Purdue. The duo shares a passion for supporting early career faculty that inspired them to endow a new professorship. Daniel Flaherty is the inaugural recipient. Full story: https://t.co/v1deDdSvIu
#pharmacysgiantleap
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Several Flaherty Lab and @Purdue_MCMP students were recognized at the @purduepharmacy Grad Student Research Day today. Congrats to Ryan Imhoff on the Jenkins-Knevel Award and Molly and Menna for poster awards! Thank you to the grad students in lab for all your contributions!
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Congrats to @Purdue_MCMP and Flaherty lab grad students @molly_youse and @Katrina_Holly98 for winning best oral presentation and best poster, respectively, at the second annual Purdue University - Notre Dame Symposium! Tons of hard work paid off. Proud of these ladies.
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Our department is hiring two positions. One in chemical biology and one in translational neuroscience. Come join a fantastic department with great colleagues!
@Purdue_MCMP is hiring for Faculty Positions in Translational Neuroscience and Chemical Biology https://t.co/kX5sAZPuZu
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@Purdue_MCMP is hiring for Faculty Positions in Translational Neuroscience and Chemical Biology https://t.co/kX5sAZPuZu
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New paper from my group and @nglab_malaria on the identification of covalent inhibitors against P. falciparum UCHL3. Keep an eye on this work in the future from our groups 😉 @Purdue_MCMP @DrugDiscoveryPU @UNMC_PathMicro
https://t.co/vz1NwBH7Ss
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