Kevin Esoh
@EsohKevin
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Human & Pop Genetics, GWAS, Bioinformatics, @SickleInAfrica fellow. #SickleCellDisease & #malaria researcher. #AncientGenomes enthusiast
University of Cape Town, SA
Joined July 2018
Now out in @TheLancetHaem!!! Our review on #SickleCellDisease in sub-Saharan Africa: transferable strategies for prevention and care. @SickleInAfrica @GeneMAPOfficial
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RT @GeneMAPOfficial: New publication by some members of the GeneMAP team & collaborators reports on 14 candidate loci from a genome-wide as….
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I note that the @H3Africa imputation panel used in this study has since been updated and enhanced substantially and now provided as the Afrigen-D Imputation Server here:
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[3] By analyzing publicly available chromatin accessibility data, I proposed a model for the developmental regulation of expression of FLT1, and hypoxia-mediated induction in erythroleukemic cells. @GeneMAPOfficial @SickleInAfrica @H3Africa @UCTHealthSci @UCTIDM @HopkinsMedicine.
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[3] With rigorous statistical and functional fine mapping, I identified three SNPs likely to explain the effect of FLT1, falling within FLT1 promoter and a candidate enhancer (not previously reported) -40kb upstream of FLT1 TSS.
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[2] I used an innovative multi-panel and association approach and showed that it is superior over selecting a "best-performing" panel. (Work is ongoing to assess how it compares to meta-imputation).
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In this @NatureComms paper ( of my PhD work,. [1] I analyzed genomic data of individuals with SCD of African descent using imputation-based #GWAS and meta-analysis and identified #FLT1 as a potential modifier of HbF level, with many other candidate loci.
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we utilized multiple imputation resources in the study and observed important factors (aside from sample size and LD) that can substantially limit the 'power' of GWAS in highly structured African populations.
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a key highlight is an evolutionarily preserved signature of epigenetic regulation of CHST15 in malarious environments that was uncovered through a combination of great @hmg_journal editorial work and our careful analysis.
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Our recent study now out in @hmg_journal identified potentially novel malaria resistance genes in Cameroon based on data that contributed to @malariagenomics studies. @GeneMAPOfficial .
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RT @GeneMAPOfficial: #Workshop: Next Generation Sequencing Analysis for Monogenic Disease in African Populations. Extended deadline: 20th O….
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Skills required to be an accomplished scientist, in Svante's own words. Courtesy of @uctelevision
BREAKING NEWS: .The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”
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RT @pontus_skoglund: Congrats to Svante and the entire @MPI_EVA_Leipzig genetics department past and present!. It's not just the Neandertha….
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RT @NobelPrize: BREAKING NEWS: .The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concer….
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RT @ICHG2023: Looking forward to listening to Prof Carina Schlebusch @cschlebu (from @UU_University)'s talk on the genetic history of Af….
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Absolutely astonishing! "Neanderthal man" gets this year's #NobelPrize in Medicine. Simply beautiful!. The "godfather" of ancient DNA studies. Read this nature piece to hear what other towering voices in the field have to say about this true hero.
nature.com
Nature - Svante Pääbo has made stunning discoveries about human evolution using ancient DNA — and his work helped to spawn the competitive field of palaeogenomics.
Today’s #NobelPrize winner Svante Pääbo is a true authority on the study of ancient DNA. He was the first to successfully clone DNA from a mummy, and in 2009, he completed sequencing of the Neanderthal genome (in collaboration with Jim Mullikin @genome_gov!).
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RT @NHGRI_Director: Today’s #NobelPrize winner Svante Pääbo is a true authority on the study of ancient DNA. He was the first to successful….
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RT @SickleInAfrica: Pain in sickle cell disease is poorly understood and patients face both medical and socioeconomic problems when seeking….
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Happening now!.@AfriPopGen
Happening today at 3pm CAT! . Kindly register here: (Meeting details can't be posted on socials).
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Only an hour before our highly anticipated webinar!.looking forward to seeing you there!.@AfriPopGen.
Very excited to host @pontus_skoglund from @TheCrick for our next @asbcb1 @AfriPopGen #webinar on Sept 22nd, 2022 at 3pm CAT (2pm BST). Registration (in case you haven't received meeting details): @H3Africa @AfSHGenetics @SAHumanGenetics @H3ABioNet
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RT @humangeneticstz: *Webinar Alert!* . Register to join @AfriPopGen COSI webinar tittled "Prehistoric African Population Structure: Early….
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