Endocrine Pathology
@EndoPath
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Official Twitter Page of the Endocrine Pathology Society and its companion journal, Endocrine Pathology #EndoPath #USCAP #EndoPathSociety #EndocrinePathology
Joined March 2017
DLL3 and SEZ6, promising targets for antibody–drug conjugates, show expression across a wide range of neuroendocrine neoplasms (NENs), including lung, Merkel cell, medullary thyroid & pancreatic tumors. Rare in non-NENs. A step toward targeted therapy! .
link.springer.com
Endocrine Pathology - Delta-like protein 3 (DLL3), a Notch ligand, has been identified in high-grade small- and large-cell lung carcinomas and prostate neuroendocrine carcinomas (NECs). SEZ6...
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Master the art of diagnosing pancreatic neuroendocrine neoplasms from even the scarcest biopsy samples! This practical guide helps pathologists make every cell count - combining morphology, IHC, and molecular tools for real-world challenges.
link.springer.com
Endocrine Pathology - Fine needle aspiration (FNA) and fine needle biopsy (FNB) procedures are increasingly employed in the diagnostic work-up of pancreatic masses. These procedures represent a...
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🚨 New in @EndocrinePath! Survival in PanNETs G2a vs G2b isn't the same!. 10-yr OS:.🟩 G1 (<3% Ki-67): 81%.🟨 G2a (3–<10%): 68%.🟥 G2b (10–20%): 44%.🖤 G3 (>20%): 23%. Splitting G2 matters for prognosis and management!. Details here 👉
link.springer.com
Endocrine Pathology - The clinical behavior of well-differentiated pancreatic neuroendocrine tumors (PanNETs) is difficult to predict. In order to define, more accurately, prognosticators for...
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Now in our journal: Authors reveal the broad hormone & TF expression landscape in 53 duodenal NETs, showing high plurihormonality & novel cell types. Gastrin & PAX6 top expression profiles, with 57% expressing multiple hormones. Dive into the full study:.
link.springer.com
Endocrine Pathology - We studied transcription factors and hormones expressed by duodenal neuroendocrine cells in a consecutively diagnosed series of 53 patients with well-differentiated duodenal...
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Can AI help tackle the diagnostic challenges of NIFTP in thyroid pathology? A new study proposes a 3-stage deep learning pipeline - showing promise, but with key hurdles ahead. 🧠🔬 Read more in @EndocrinePath .
link.springer.com
Endocrine Pathology - The recent introduction of the term non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) marked a pivotal shift in the classification of...
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RT @SpringerPath: We are very happy to announce @EndoPath's IF is now 14.7. 2/90 Pathology. 7/191 Endocrinology & Metabolism. Congrats to….
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Silver‑based reticulin stains are revealing more in endocrine tumors - from pituitary to adrenal and neuroendocrine lesions. With AI and digital pathology stepping in, diagnostics are getting sharper. Want the full breakdown? Dive into this game‑changer!.
link.springer.com
Endocrine Pathology - The reticulin framework, composed mainly of type III collagen, is an essential structural component of biological tissues. Reticulin stains, particularly silver-based methods,...
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Pediatric DICER1-associated thyroid carcinomas may show a distinct tumor-in-tumor pattern with high-grade features and CHEK2 variants in addition to established atrophic changes. Findings may shed light on progression via the ATM-CHEK2-TP53 pathway!.
link.springer.com
Endocrine Pathology - In the thyroid gland, during childhood or adolescence, DICER1-driven tumors include differentiated follicular thyroid carcinoma and, more rarely, poorly differentiated...
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🎉 Congratulations to our Editor-in-Chief, Dr. Ozgur Mete, on receiving the 2025 Springer Nature Editorial Contribution Award and Author Service Award! A well-deserved recognition of his leadership, dedication, and service to the endocrine pathology community. 👏🔬🧬.
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Take note: a true rarity just dropped in Endocrine Pathology! This case report details three synchronous, histologically distinct PitNETs in one patient - confirmed by epigenomic profiling. No hormonal symptoms. A must-read:
link.springer.com
Endocrine Pathology -
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ABCC3 marks the quiet zone!. New study in Endocrine Pathology shows ABCC3 is absent in aldosterone-producing lesions and inversely linked to CYP11B2 - making it a promising marker to distinguish normal adrenal cortex from APAs.
link.springer.com
Endocrine Pathology - ATP Binding Cassette Subfamily C Member 3 (ABCC3) is a membrane transporter that exports diverse compounds, influencing drug resistance in cancers and impacting metabolic and...
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Small tumors, big surprises! Non-functioning duodenal NETs may look quiet, but their hormone profiles speak volumes. Somatostatin and friends could be key to predicting aggressiveness - turns out, size isn’t everything! Read it now in Endocrine Pathology!.
link.springer.com
Endocrine Pathology - Duodenal neuroendocrine tumors (Duo-NETs) may arise in the ampullary and non-ampullary duodenum. Non-functioning Duo-NETs (NF-Duo-NETs), which account for most cases, may...
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RT @EndoPath: Oncocytic thyroid tumors are packed with mitochondria, but what do we know about their proteome? Herein, authors link dysregu….
link.springer.com
Endocrine Pathology - Oncocytic thyroid tumors are characterized by an elevated mitochondrial density within the cells, distinguishing them from other thyroid tumors, exhibit distinct clinical...
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RT @EndoPath: Study from 🇸🇪 find TERTp mutations in 12% of minimally invasive FTCs. More common in older patients, these (often subclonal)….
link.springer.com
Endocrine Pathology - De-escalation of thyroid cancer treatment is crucial to prevent overtreatment of indolent disease, but it remains important to identify clinically aggressive cases. TERT...
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RT @EndoPath: Glucagonomas: rare pancreatic tumors causing a striking skin rash and packing molecular surprises. These large tumors were mo….
link.springer.com
Endocrine Pathology - Glucagonomas are functioning pancreatic neuroendocrine tumors (PanNETs) responsible for glucagonoma syndrome. This study aims to shed light on the clinicopathological and...
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RT @EndoPath: Our journal features two ground-breaking papers in which a molecular link between well-differentiated NETs and high-grade NEC….
link.springer.com
Endocrine Pathology - High-grade or grade 3 epithelial neuroendocrine neoplasms (G3 NEN) are now divided into grade 3 well-differentiated neuroendocrine tumor (G3 NET) and neuroendocrine carcinoma...
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RT @EndoPath: New study reveals that separately fixed thyroid tumor samples, including lymph node metastases, preserve DNA and RNA quality….
link.springer.com
Endocrine Pathology - Formalin-fixed paraffin-embedded (FFPE) tissue samples are important for genomic analysis of thyroid carcinomas, particularly for various molecularly targeted therapies....
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RT @EndoPath: New insights into functioning PanNETs! 🧬 ATRX/DAXX mutations & ALT are linked to aggressive behavior in insulinoma and other….
link.springer.com
Endocrine Pathology - Functioning pancreatic neuroendocrine tumors (PanNETs) represent a subset of PanNETs that cause symptoms due to hormonal activity. Insulinoma is the most common functioning...
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