Exciting Instruments
@EI_science
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Built to unlock the power of single-molecule fluorescence spectroscopy Follow us on Bluesky! @ei-science.bsky.social
Sheffield, UK
Joined September 2021
Hello to all who's left ;-) We thought this may be a good time to re-introduce ourselves! We are a growing team of scientists and engineers spun out of Dr. Tim Craggs’ research lab (@Craggs_Lab) with a mission of simplifying single molecule spectroscopy to enable the broadest
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🇨🇭Looking for a fast and precise way to screen for drug-induced conformational changes? Catch Roman at #PSDI2025 this week (and check out poster PO21) to discover Exciting insights on how our tools will help you bring your static biomolecular structures to life. 🇦🇹 How about
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📢 No more waiting... our Exciting Seminars are back! Join Tim Craggs and @shenk0128 on the 20th November for a deep dive into Kuang's recent work with mapping the global conformation of the Rag GTPase heterodimer using single-molecule FRET. Kuang is a professor with the
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✨ Watch Dr Erin Cutts from the University of Sheffield as she uses the EI-FLEX and imagine what kinds of discoveries you could make with one in your own lab.... We are looking for labs and core facilities to house an EI-FLEX for 2 months at no cost. Run your own samples, on
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What happens when fluorescence detection reaches nanosecond precision? Recent work in time-resolved single-molecule FRET from Howard et al. reveals fast, transient conformations and connects photon-level observables with structural and dynamic models. Fluorescence is evolving
biorxiv.org
DNA helicases undergo conformational changes; however, their structural dynamics are poorly understood. Here, we study single molecules of superfamily 1A DNA helicase Rep, which undergo conformatio...
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🚀 This month's newsletter includes an extremely Exciting initiative - submit a proposal on how you'd use the EI-FLEX in your lab, and you will be considered for a 2-month, no obligation trial! Read the newsletter for more information, plus see smFRET in action, save the date
linkedin.com
Hi there, I hope you're doing well. I'm excited to say our Exciting Seminars will be back with a bang in November! Join me and Kuang Shen from UMass Chan Medical School as we explore his latest...
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How can our super stable, compact and easy-to-use single molecule tools bring your static models to life? Our Senior Application Scientist Mahmoud shared a poster on this topic at last week's Advances in Structural Analysis of Biomolecules conference. You can check out his
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Probing molecular interactions often means long prep times - purification, immobilisation, multiple steps, and extensive training - before you even see results. Fluorescence Correlation Spectroscopy (FCS) changes that. By capturing the mobility of fluorescently labelled
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Congratulations to Dylan Doxsey and Kuang Shen on their new paper, 'Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing' 🙌 They used our stable, compact instrument the EI-FLEX and smFRET measurements to emphasise that Rag GTPases’ global
pnas.org
The Rag GTPase heterodimer is a central mediator of amino acid sensing in eukaryotic cells. When amino acids are abundant, it binds to the mechanis...
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Average doesn't really exist... so why measure it? - Average ≠ reality - Outliers matter - Molecules don’t follow the rules we set Single-molecule measurements reveal what ensemble averaging hides, and our compact and easy-to-use instrument has been designed to help
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🚀 Ready to take the next exciting step in your career journey and join our mission to democratise single-molecule analysis, bringing unprecedented molecular insight to every life science researcher and drug developer through tools that are as powerful as they are effortless to
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It was brilliant to talk dynamic single-molecule data with fellow scientists and researchers yesterday at The Francis Crick Institute. 🇩🇪 Next stop - Advances in Structural Analysis of Biomolecules at Charité in Berlin on the 23rd - 24th October! Will we see you there?
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⚡ Ready to discuss cutting-edge research, exchange innovative ideas, and foster new collaborations within the single-molecule community? Join Tim Craggs, Paul Wheeler and fellow researchers, postdocs, students, and scientists working in the single molecule space on Monday at
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Can smFRET deliver highly reproducible, absolute distance measurements? Absolutely! As shown in the publication of Hellenkamp et al.'s 2018 'Precision and accuracy of single-molecule FRET measurements - a multi-laboratory benchmark study' paper. The team used: - blind
nature.com
Nature Methods - A multi-laboratory study finds that single-molecule FRET is a reproducible and reliable approach for determining accurate distances in dye-labeled DNA duplexes.
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🚀 Our journey since spinning out from the University of Sheffield in 2021 has been a very Exciting one, and it's brilliant to see our CEO and founder @Craggs_Lab recognised as Entrepreneur of the Month by Insider Media. Check out Tim's comment on the recognition below 👇
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🚀 Our 'professor in a box', a quick-watch smFRET explainer video, a very exciting Chair appointment and more... see what we've been up to in September in the latest edition of our newsletter. https://t.co/jXQ5rGhTuQ Prefer to receive this straight into your inbox? Subscribe
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"Absolutely gorgeous!" That's how Edwin Antony describes the data from our EI-FLEX instrument in his Exciting Seminar, where he discusses how DNA context regulates the myriad roles of RPA. 👀 Check out the seminar in full to learn more: https://t.co/H1YHwcLNr4 📖 And the
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