@RiganoESQ
@elonmusk
@DiderRaoult
42 patients
Non randomized
Non blinded
Not analyzed via intention to treat
Surrogate primary endpoint
6 days follow up
Interesting? Sure.
But this is the kind of thing that should prompt a legit clinical trial, not advocacy for broad use of an unproven drug in 1000s of people.
@elonmusk
I am co-author of the original paper.
Was just on television discussing HCQ, first well controlled study against COVID-19.
600 mg HCQ per day after 6 days, 90% of patients tested COVID-19 negative. 96% of control group tested positive after 6 days.
DM or grigano1
@jhu
.edu
@elonmusk
Update: As per
@DiderRaoult
- the study shows combination of HCQ * Azithromycin is most effective treatment
1 control group (placebo)
1 HCQ group
1 HCQ * Azithromycin group
follow his youtube for more info, major announcements coming ...
@elonmusk
@DiderRaoult
UPDATE:
Full peer reviewed study has been released by Didier Raoult MD, PhD .
After 6 days 100% of patients treated with HCQ + Azithromycin were virologically cured
p-value <.0001
@RiganoESQ
@elonmusk
@DiderRaoult
To everyone saying, "what's the harm?" & "it's been around for 50 years and totally safe!", here's a good summary of why we should be cautious re: chloroquine, including the fact that for at least one virus, chikungunya, it appears to worsen the disease. (
@Jsw912
@RiganoESQ
@elonmusk
@DiderRaoult
It is not "proven". π
I agree there should be a trial - as in a well designed, blinded, randomized clinical trial with a patient-centered endpoint (e.g death, need for intubation, ICU days, etc...)
That is not remotely the same thing as just giving the drug to everyone.
@DrEricStrong
@RiganoESQ
@elonmusk
@DiderRaoult
Completely agree! 6 pts βlost to follow upβ and no ITT. In fact 3 pts went to ITU and 1 died! In saying that, chloroquine and hydrozychloroquine are cheap, widely available and pretty safe PO drugs. Worth a shot where little else available.
@TinaVaine
@RiganoESQ
@elonmusk
@DiderRaoult
Ethics?!?
Are you familiar with the ancient concept of primum non nocere, or "first, do no harm"?
There is nothing ethical in giving a potentially dangerous drug of unknown benefit to people & depleting supplies for those who actually need it for established indications.
@DrEricStrong
@RiganoESQ
@elonmusk
@DiderRaoult
Thank you!
Everybody with knowledge about clinical trials can easily identify the weaknesses of this paper. Do people really want a treatment that was only tested on 20 participants?
@DrEricStrong
@RiganoESQ
@elonmusk
@DiderRaoult
I also find it dubious that they're trying them in conjunction with Azithromycin, which is an antibiotic and would only be useful if patients have pneumonia or are at risk of developing it already. If that's the case, then it's entirely possible that the Z-pak is what's working.