Dr. Dale Bredesen
@DrDaleBredesen
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Dr. Dale Bredesen is the author of The End Of Alzheimer's, the Chief Science Officer of Apollo Health, and a pioneer in brain health research.
Joined March 2016
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A review of existing meta-analyses found harmful associations between sugar consumption and many health outcomes including endocrine, metabolic, cardiovascular, and cancer outcomes.
Digging into all the relationships, it’s as bad or worse than you think!
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A recent study found that participants who used a vitamin D supplement were almost 40% less likely to develop dementia than those who didn’t. I recommend a target value of 50–80 ng/mL.
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It took just 2 hours for particles of polystyrene, a common plastic used in food packaging, to cross the blood-brain barrier in mice. If you microwave plastic containers, drink from plastic, or store food in plastic, switch to glass or silicone now!
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There is no shortage of conflict of interest in Alzheimer’s research or treatment. Perhaps that’s why billions of research dollars have produced no long-term benefit to patients. Dr. Robert Lufkin's idea here may not be a bad one.
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Another drug trial for Alzheimer’s disease has failed. Like so many others, it used an antibody to remove amyloid. Focus on identifying the contributors to cognitive decline, then target them—this is what has worked far better than any other approach.
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Good news for those who consume dark-green, leafy vegetables, nuts, seeds, and beans as recommended in the KetoFLEX 12/3 diet. Magnesium has been linked with a lower dementia risk in a new study.
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Older, damaged cells may play a role in Alzheimer’s, and that’s why fasting is an important part of a successful plan. Fasting helps to induce autophagy, resulting in cell death and renewal.
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As ridiculous as it sounds, olive oil alone has a better track record of protecting brain health than most of our approved Alzheimer’s drugs. Of course, we can do better than that.
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A single strain of bacteria has been identified as the likely culprit behind the majority of Parkinson’s cases. These Desulfovibrio bacteria live in the gut and can be detected and removed, which may prevent the disease.
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A recent research study discovered that Alzheimer’s patients with greater iron accumulation in their brains, exhibited faster cognitive decline, strengthening evidence that iron buildup may be linked to poor cognition and memory loss.
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While 90 minutes of exercise produced more brain-derived neurotrophic factor (and raised blood levels 4 to 5x), just 6 minutes of high intensity exercise was enough to produce BDNF.
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New research supports my theory that amyloid is part of the brain’s protective response to insults, and is produced as part of the innate immune system’s activation, underscoring the need for evaluation of chronic pathogens and ongoing inflammation.
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Cat’s claw has been shown to inhibit and reduce brain plaques and tangles. Does that surprise you? It actually joins a long list of other herbs with neuroprotective benefits, as covered in this paper from Ayurvedic physician Dr. Ram Rao and colleagues:
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The multifactorial approach to treating
#Alzheimers
continues to demonstrate cognitive improvement. See our recently published paper in the International Journal of Molecular Sciences.
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A recent study showed that a higher consumption of ultraprocessed foods is linked to cognitive decline. Sounds like a good reason to change your diet!
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Until now, therapeutic development for Alzheimer’s disease has been almost uniformly unsuccessful, with over 400 failed clinical trials. Our new study provides the first clinical trial success in treating dementia.
Pre-print:
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Chris Hemsworth is taking a step back from acting to prioritize his health after learning he had two copies of the APOE4 gene. Some say it isn’t useful to know APOE4 status. I disagree. You can take action to reduce your risk. Good job,
@chrishemsworth
!
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New research from
@Cambridge_Uni
may have pinpointed additional reasons why including intermittent fasting can help decrease inflammation and protect your brain from Alzheimer’s and dementia.
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Yet another study has found that taking a multivitamin can improve memory and slow cognitive aging. Imagine the results this study would have had if they used vitamins targeted towards brain health or used a precision medicine approach.
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"New" research has linked gut inflammation & Alzheimer’s (is anyone surprised?). As levels of calprotectin rose, so did beta-amyloid levels.
It’s almost as if beta-amyloid is a natural part of your innate immune response, as we have pointed out for years.
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New research from Edith Cowan University has found a link between decreased muscle function and a 2x increase in risk for dementia. What does your muscle mass retention plan look like?
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Our precision medicine protocol, which targets the root causes of cognitive decline, produced the first clinical trial success for treating Alzheimer's and MCI. 84% of our participants experienced improvements in cognition.
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I enjoyed talking with
@Mercola
about the ReCODE protocol. Unlike previous approaches, ReCODE identifies the underlying drivers of cognitive decline and then addresses them using a precision medicine approach. This has produced unprecedented improvements. .
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Cat’s claw has been shown to inhibit and reduce brain plaques and tangles. Does that surprise you? It actually joins a long list of other herbs with neuroprotective benefits, as covered by Ayurvedic physician Dr. Ram Rao and colleagues. Link in bio:
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Research from South Korea has strengthened the link between gum disease and death from dementia. According to a study of over 1.1M older (>65) adults, those who didn’t have treatment for periodontal disease were almost twice as likely to die from dementia.
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We strongly disagree with the Alzheimer's Association's assertion "there is still no treatment that slows progression of the disease, let alone stops or reverses it." Real progress has been made—and published repeatedly—using a precision medicine approach.
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New evidence acquired by @guardian shows chemical giant Syngenta has been working overtime to cover up research linking their weedkiller to Parkinson’s disease. We can’t let these corporations hurt people for profit.
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Science vs. Business: Science lost.
Today the FDA approved aducanumab to treat Alzheimer’s disease at the cost of $56,000 per year despite the fact that it does not improve, nor stabilize cognition, but may slow cognitive decline — shown in one trial at one dose.
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Dr. Chalfont and colleagues just published a paper of 6 patients with dementia, who showed improvement using a precision medicine protocol based on our published papers. It is uplifting to see one group after another improving cognition in patients.
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At least more people are realizing Alzheimer’s is preventable, though many still claim cognitive decline cannot be reversed, despite multiple peer-reviewed publications to the contrary. If everyone started prevention at 40, we could make Alzheimer’s rare.
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The FDA’s approval of Aducanumab is a big win for Biogen and a big loss for everyone else including Alzheimer’s patients and others suffering cognitive decline.
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There is a direct relationship between Vit D deficiency, Alzheimer’s disease, and cognitive decline. Vit D plays a role in the transcription of hundreds of genes involved in cellular processes of neuroplasticity, the immune system, and more.
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The development of Alzheimer’s is linked to mitochondrial deficiency. Intermittent fasting, which upregulates healthy mitochondria through autophagy, offers powerful neuroprotection.
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New research has found anyone given a diagnosis of Herpes is nearly twice as likely to develop dementia, adding evidence for a viral role in dementia. It’s also a great reason to aggressively treat outbreaks & adopt an ongoing HSV prevention protocol.
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My medical colleagues at 15 different sites and I have just published a paper describing 100 patients with Alzheimer’s or pre-Alzheimer's who achieved documented, quantified improvement in cognition using our comprehensive protocol.
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“Those with a history of hypothyroidism were associated with an 81% increased risk of having dementia.” It’s time for more research into hormonal health, especially since those taking medication for hypothyroidism had an even bigger risk increase.
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Claims that Mainstream Medicine has said we were wrong about, but research has proven:
•Viruses, environmental exposures, and lifestyle practices contribute to dementia
•A precision medicine protocol can prevent & reverse cognitive decline
•Amyloid doesn't cause Alzheimer’s
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Any successful approach to treating dementia is likely to include some treatment for the gut. New research provides more evidence of the gut’s role in brain health.
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Does that number surprise you? I spoke with
@CBSNews
about the heritability of Alzheimer’s. The truth is, you should focus on your lifestyle, not your genetics.
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Those carrying the APOE4 gene allele are at greater risk for developing severe COVID, and new research shows long-term risks follow infection, as well. Another reminder of the connection between COVID and brain health.
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Recent research outlines a correlation between gut health and neurological diseases. Specifically, people living with inflammatory bowel disease face a substantially higher risk of developing dementia, Alzheimer’s, and Parkinson’s.
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I'm headed to Japan where I’ll appear once again on the television show, The Most Useful School in the World, hopefully helping the many viewers of that popular series to avoid or reverse cognitive decline.
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For neuroprotection, I recommend a vitamin D level between 50-80 ng/ml. It’s also important to take vitamin K2 (100 mcg) with vitamin D3 to ensure the calcium is absorbed by your bones, rather than accumulating in your arteries.
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Even with the mounting evidence that ultra-processed foods are a cause of everything from anxiety to cancer, there’s no real movement toward changing anything.
You can take the first step. Eat healthier by researching KetoFLEX 12/3.
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If they ever do create an Alzheimer's pill with any efficacy (as ReCODE has), it will likely have the same physiological impacts as a healthy diet but be much more expensive. So why not save money and live healthier by starting a good diet?
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The only thing scarier than brain disease is feeling like there is nothing you can do about it. The good news is, our evidence suggests you can drastically reduce your risk for developing Alzheimer’s disease.
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Blood vessels can sense the metabolic state of neighboring neural cells in the brain and alter vascular function in response, underscoring the importance of insulin sensitivity to protect the blood-brain barrier.
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Having diabetes increases one’s risk of developing dementia by 73%, but for type-2 diabetics, making small changes to your daily eating and exercise habits can lower this risk significantly.
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Proud to coauthor this paper, w/ Dr. David Perlmutter & lead author Prof. Richard Johnson, exploring the role of fructose & cerebral metabolism in Alzheimer’s. Reducing fructose exposure may lead to benefit in the prevention and treatment of this disease.
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New research suggests brain cells don’t die because of the build-up of protein aggregates, but instead because of the inability of the body to silence the stress response in these cells. With the protocol, we may be able to turn off this response.
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Merry Christmas and Happy Hanukkah to my friends who celebrate. This year, let’s take comfort in each other’s company and treasure the things that matter more than the gifts we receive: strong relationships, happiness, and health (and particularly brain health)!
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Harvard-trained psychiatrist and past Facebook Live guest
@DrUmaNaidoo
has great news for coffee drinkers. According to her, the ideal amount of daily coffee is 3 cups, as it has the most potent effect on preventing cognitive decline.
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In the past people recommended against genetic testing for Alzheimer's because you couldn't do anything about it. That's no longer true. There's a lot you can do. Now there is effective prevention and reversal, especially for early cognitive decline.
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What if the olive oil you are consuming is adulterated? In 2010, more than 50% of imported olive oils were mislabelled as extra virgin. So, how can you tell if your oil is authentic?
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Here’s a great watch if you want to learn more about what we're doing to reverse cognitive decline.
#Alzheimers
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According to a new study, individuals with type 2 diabetes experience microstructural changes in the brain found in the regions that control cognition and mood, which may explain the increased risk of mood disorders and cognitive deficits.
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Looking for an important way to improve this year? Model your New Year’s resolution around the goal you really need to achieve: brain health. How? Adopt a Ketoflex 12/3 diet, pick up a new cardiovascular exercise, detoxify your house, or pick up a new meditative practice.
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Today the FDA approved aducanumab to treat Alzheimer’s disease at the cost of $56,000 per year despite the fact that it does not improve, nor stabilize cognition, but may slow cognitive decline — shown in one trial at one dose.
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Using data from over 300,000 participants, researchers found 15 factors associated with early onset dementia. Those factors include many we have covered previously like APOE status, vitamin D deficiency, diabetes, and more.
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We recommend both cardio and strength training for long-term brain health, but a new study shows that you don’t need to rack up gym hours to benefit. Short intense exercise can increase brain-derived neurotrophic factor, according to a small study.
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If you look up functional medicine in Wikipedia, you’ll see that “it has been described as pseudoscience, quackery, and at its essence a rebranding of complementary and alternative medicine.”
1/x
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Please don’t put your head in the sand and wait for dementia! We have documented the reversal of cognitive decline in Alzheimer’s and MCI since 2014. ALL OF US who are 40+ should find out our Alzheimer’s risk, and begin prevention or earliest reversal.
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New mRNA technology shows promise for treating heart disease. Since heart disease is also tied to cognitive decline, this discovery may prove to have beneficial brain effects, as well.
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"Mild Cognitive Impairment" is often dismissed, but it is a later stage of illness. It is the 3rd of 4 phases of Alzheimer's and often develops over a decade-plus. Don't wait to start prevention or reversal - those who act early achieve the best results.
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Vitamin D deficiency has been associated with a decrease in neurocognitive functioning, but how it affects the brain’s physical structure is still up for debate. A recent study set out to nail down its effect on brain aging and total gray matter.
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Vitamin D deficiency at the time of MS diagnosis has been linked to cognitive impairment. Previous studies have linked Vitamin D with MS progression and development, but less research has been done connecting it with cognitive impairment.
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As our research over the past 30 years showed, Alzheimer’s is driven largely by insufficient energetics and excess inflammation. Thus there are many preventive strategies affecting these two key drivers. Here are six simple strategies to reduce risk.
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A team at the University of Calgary has identified a key calcium channel for Alzheimer’s disease. More here:
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Stress leads to an increase in cortisol levels which can be toxic to our brains—in particular the memory-consolidating hippocampus, one of the first structures to be assaulted by Alzheimer's disease. What do you do to de-stress?
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You can tell a lot about a person by looking at their eyes, and that may include whether they have Alzheimer’s disease or not. New research has found changes in the retina correlate with changes in the brain, including the development of Alzheimer’s.
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Excited to announce The First Survivors of Alzheimer's. In my latest book, you’ll gain a better understanding of what it’s like to live with this debilitating disease and learn how a precision medicine approach paves the way to success for those suffering.
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Agreed to all five and many more! Grains in particular are unhealthy for brain health. Ditch the processed foods and load up on non-starchy vegetables, healthy fats and clean proteins. Your brain health will thank you.
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A new study finds a link between gut inflammation, aging, and Alzheimer’s disease. We’ve said all along that the gut and brain are connected and that gut inflammation contributes to Alzheimer’s.
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New research has found that practicing yoga regularly had significant benefits for women’s brain health. Specifically, those who practiced yoga saw less brain matter loss, better cognitive function, and a higher expression of anti-aging molecules.
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Alzheimer's research has had quite a shake-up. I am grateful to Megyn Kelly for helping to spread the message. Watch my interview with her here:
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A Colombian man with a gene mutation that should have given him full-blown dementia evaded the disease, apparently due to a mutation. His brain and genetics may help find a new prevention for neurodegenerative diseases and fits well with our theory of AD.
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The mainstream view of neurodegenerative diseases such as Alzheimer’s, Lewy body disease, and Huntington’s disease is that these are due to “aggregated proteins”, but in each case these aggregates are proving to be protective responses to insults.
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According to research from the Virginia Tech Carilion School of Medicine, there are five micronutrients whose levels are “strikingly lower” in Alzheimer’s brains. Do you have the nutrients you need to keep your brain healthy?
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Looking to make a smart investment? Invest in prevention.
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The APOE ε4 gene is a major, common genetic factor in the development of late-onset Alzheimer’s disease, but a new study shows that two rare variations of the gene could reduce your risk by as much as 60%!
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Diagnosis of Alzheimer’s has been improved with simple blood tests now on the market, and these may help us diagnose patients earlier.
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New research reveals that the Epstein Barr virus may be the leading cause for multiple sclerosis. Since nearly everyone harbors EBV, this finding implicates the immune response to the virus.
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Fish is a true superfood for brain health and beyond. I always recommend low-mercury wild-caught seafood. Think SMASH (sardines, mackerel, anchovies, salmon, and herring).
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Mars is being sued because Skittles contain “known toxin” titanium dioxide. Toxins such as these are emerging as a potential players in the development of Alzheimer’s disease, and we’re far more exposed to them than we’ve ever been before.
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The short answer is no. The slightly longer answer is no, they’re expensive, ineffective, and potentially deadly. The amyloid hypothesis has been disproven countless, very public times. So why are we still treating a symptom instead of the cause?
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In order to help make optimal brain health as accessible as possible, there will be a one-day sale, on March 6, of The End of Alzheimer’s ebook, for $1.99. I hope that this will help many in need. Let’s all make Alzheimer’s a rare disease, as it should be.
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Herpes simplex virus is associated with Alzheimer's, and we're now learning why cold sores appear after stressful periods. Stress activates interleukin-1 that reactivates the virus. Manage stress and treat outbreaks to reduce risk.
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Yes, amyloid plaques are found with Alzheimer’s because they are part of the immune response to many different pathogens, toxins, and other insults. Amyloid-beta peptides represent some of the many mediators of Alzheimer’s, but it’s upstream contributors that we want to target.
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New research from UNC Chapel Hill has found a link between taking a daily probiotic and slowing cognitive decline.
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Alzheimer’s is not simply a brain disease—there are systemic abnormalities such as inflammation and reduced mitochondrial function. New research supports that by finding declining skeletal muscle strength as another indicator of Alzheimer’s.
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We talk a lot about the importance of sleep, but did you know that the position in which you sleep can also benefit your brain?
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The Mediterranean Diet is a vast improvement from the Standard American Diet (SAD) in preventing cognitive decline, but falls short in addressing many of the parameters necessary for neuroprotection. We developed
#KetoFLEX123
to bridge that gap. More here:
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A new study has found that otherwise healthy middle-aged adults who experience nightmares are 4x more likely to face cognitive decline, and 2x more likely to be diagnosed with dementia.
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New research out of the Netherlands has characterized five subtypes of Alzheimer’s disease. This is an important recognition that there is much more going on in Alzheimer’s than the creation of amyloid plaques!
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Diet is unquestionably a big component of longevity and Alzheimer’s risk. The diets of those who live longest tend to be plant-based, low-glycemic, and not over-consuming. Coffee and dark chocolate are often shown to be beneficial, as well.
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Are you suffering from chronic inflammation, as so many are? You may be deficient in vitamin D. A new study has shown that participants with lower levels of vitamin D had higher C-reactive protein levels, indicating inflammation.
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Achieving longevity (and brain health) is more than just what you eat and how often you work out. Personality traits are important, too. Among people who lived to 100, the most common traits were having a positive attitude and being emotionally aware.
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Identifying six Alzheimer’s sub-types has led to unprecedented breakthroughs in treatment. Learn what makes each type different.
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I recently met with Ivor Cummins. We discussed a wide range of topics including causes and subtypes of Alzheimer's disease, the ApoE4 gene, Keto vs. KetoFlex 12/3, fiber, saturated fat, oral health, sleep apnea, and the ongoing ReCODE clinical trial.
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Many of us drink green tea, in large part for EGCG, an antioxidant shown to improve cognition and help prevent cognitive decline. Now a fascinating study shows EGCG binds to a key protein that protects the genome & suppresses cancer formation.
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