✅ Inflammatory Fibroid Polyp (IFP) Submucosal tumor of bland spindle cells, numerous small blood vessels, and a prominent inflammatory infiltrate rich in eosinophils. "onion-skin" arrangement of CD34+ spindle cells around blood vessels is a key feature #PathTwitter #Pathology

❌ Schwannoma S100-positive nerve sheath tumor GI schwannomas often show a peripheral lymphoid cuff Lack the prominent eosinophilic infiltrate and characteristic vascular arrangement of an IFP. #PathTwitter #Pathology #GIPath

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❌ GIST CD117 (c-KIT) and DOG1 positive mesenchymal tumor Lack prominent eosinophils #PathTwitter #Pathology #GIPath

What IHC finding supports your diagnosis?

The prominent eosinophils plus concentric arrangement of cells around vessels is a clue! What IHC finding supports your diagnosis? A) ALK positive B) CD34 positive C) CD117 positive D) S100 positive #PathTwitter #Pathology #GIPath

Diagnosis?

55-year-old with submucosal nodule in the gastric antrum. Diagnosis? A) Gatrointestinal Stromal Tumor B) Inflammatory Fibroid Polyp C) Schwannoma #PathTwitter #Pathology #GIPath https://t.co/PV6ScxhKRr

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Answers: Cronkhite-Canada Syndrome, Esophagus Mean age 59, M:F 3:2 Triad of GI polyposis, protein-losing enteropathy, and ectodermal changes Dysplasia is essentially never seen Diffuse polyposis in stomach, small bowel, and colon, but characteristically spares the esophagus High

❌Ménétrier’s Disease Massive foveolar hyperplasia Stomach only (spares colon) #GIPath #PathTwitter #Pathology

❌Lymphangiectasia Villi are swollen and bulbous (like Cronkhite-Canada), but the dilation is in the lymphatic channels (lacteals) Pediatric onset or due to obstruction #GIPath #PathTwitter #Pathology

❌Juvenile Polyposis Identical polyp to Cronkhite-Canada Dysplasia may be seen and background mucosa is normal (both unlike Cronkhite-Canada) #GIPath #PathTwitter #Pathology

The diffuse polyposis in this condition is also seen in all of the following EXCEPT

The patient also had alopecia and nail dystrophy. The diffuse polyposis in this condition involves all of the following locations EXCEPT A) Stomach B) Duodenum C) Esophagus D) Rectum #GIPath #PathTwitter #Pathology

What is the diagnosis?

59 year-old with diarrhea undergoes colonoscopy. What is the diagnosis? A) Lymphangiectasia B) Juvenile Polyposis C) Ménétrier’s Disease D) Cronkhite-Canada https://t.co/P4Y3L3gw4T #GIPath #PathTwitter #Pathology

Hey #PathTwitter! How do you look up 🙄 things at the scope? 🔬 🔍Google search 💰Expert Path 📖Crack open a textbook 👋Ask a friend Running 🏃 an anonymous survey on resource usage. It is a 1 - 2 minute survey and I would love your input! https://t.co/qfEh6pmEN6 #Pathology

Cytology Search Engine: https://t.co/TCRvobnQXn Searches time-stamped lecture videos and texts. 🙂 If you find this helpful (or not 🙃), comment below! #Cytology #Pathology #Python #PathTwitter #Cytopath https://t.co/xMcylOIimO

✅ Endometriosis! The cytologic diagnosis of endometriosis in peritoneal fluid relies on finding the classic triad: 1) endometrial glandular cells, 2) endometrial stromal cells (not always seen), 3) hemosiderin-laden macrophages (evidence of old hemorrhage). Alongside are

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❌ Malignant mesothelioma: Key features of mesothelioma like large, knobby clusters are not seen. #CytoPath #PathTwitter #Pathology

❌ Metastatic adenocarcinoma: This would show malignant features, such as nuclear atypia, hyperchromasia, and abnormal clustering. #CytoPath #PathTwitter #Pathology