Deryn LeDuke Profile
Deryn LeDuke

@DerynOLeDuke

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Joined July 2022
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@DerynOLeDuke
Deryn LeDuke
1 year
… I have attached the graphical abstract and our summary in this thread, and if anyone has additional questions about extracting snail ooze, feel free to ask! :) Working with Ed Cargot and Dr. Olofs was a blast. Happy April everyone! 3/3.
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@DerynOLeDuke
Deryn LeDuke
1 year
. and I am so proud of the work that we have done doing free-moving 1P imaging in snails. This project demonstrates that free-climbing is likely conserved across evolutionary species, and was probably the reason why humans evolved. 2/3.
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@DerynOLeDuke
Deryn LeDuke
1 year
Hi Everyone, I am so excited to announce my collaboration with the @Olofs_Lab to identify a novel neural mechanism for adrenaline and free-climbing in snails! This project came together so fast. 1/3
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@DerynOLeDuke
Deryn LeDuke
2 years
RT @NatGeo: Nearly everything we do contributes to our carbon footprint. But a two-wheeled solution is zipping through the world at 20 mile….
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@DerynOLeDuke
Deryn LeDuke
2 years
Now that I have officially messed up my first twitter thread, I would like to also show what #ChatGPT wanted me to write for this paper (and I will admit, I was definitely inspired by the emojis):
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@DerynOLeDuke
Deryn LeDuke
2 years
7/7 Thank you to @science_is_hard, Amy Cao, and Anousheh Bakhti-Suroosh for their helpful discussion! The link to the full paper is here:
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@DerynOLeDuke
Deryn LeDuke
2 years
6/7 Our model integrates findings from cognitive, computational and molecular neuroscience to offer a comprehensive understanding of anxiety and depression. I hope it can inspire healthy discussion and some cool papers in the future! ✨.
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@DerynOLeDuke
Deryn LeDuke
2 years
5/7 We also highlight the role of neuroplasticity and neuromodulation in our model (#neurotensin? @haoli1988 👀). Stress and prolonged neuromodulator/transmittor dysfunction can induce structural and functional changes in key brain regions, reinforcing disordered circuitry (F3).
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@DerynOLeDuke
Deryn LeDuke
2 years
4/7 The transition between top-down and bottom-up processing is critical for healthy function, and when one's ability to process new stimuli becomes disrupted or biased towards one of these modalities, anxious, depressive, and anxious-depressive phenotypes can develop (F1-2).
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@DerynOLeDuke
Deryn LeDuke
2 years
3/7 We combine computational, algorithmic, and biological data to propose how top-down and bottom-up processing can be represented in the energy landscape of the brain via a bimodal attractor state (F1).
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@DerynOLeDuke
Deryn LeDuke
2 years
2/7 Why do anxiety and depression present such different phenotypes, despite often being comorbid? How are these disorders distinct in the brain? We propose a novel theoretical model based on David Marr's three levels of inquiry. .
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@DerynOLeDuke
Deryn LeDuke
2 years
1/7🧵 I'm excited to share my paper titled "Anxiety and Depression: A Top-Down, Bottom-Up Model of Circuit Function" which I coauthored with @matildee_rose , @RayLMir and @kaymtye published in @NYASciences awarded by @BlavatnikAwards (graphical abstract below).
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@DerynOLeDuke
Deryn LeDuke
2 years
RT @ScienceMagazine: The widespread deployment of outdoor electric lighting means that the night is no longer dark for most people. A new….
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@DerynOLeDuke
Deryn LeDuke
2 years
. Inspired by David Marr's three levels of inquiry, we combine computational, algorithmic, and biological data to construct a theoretical model which argues that the energy landscape of the brain can perseverate in top-down and bottom-up processing modalities. 2/n.
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@DerynOLeDuke
Deryn LeDuke
3 years
RT @willaahhh: @janna_e_haider lol you're not pro-union? cool cause you do not seem very pro-strategy either
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@DerynOLeDuke
Deryn LeDuke
3 years
RT @LeTourFemmes: 🚴‍♀️ Double whammy for 🇳🇱@marianne_vos ! She takes the stage and the overall lead! 👏.🎥 Here are the highlights of the 2nd….
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@DerynOLeDuke
Deryn LeDuke
3 years
RT @LeTourFemmes: 💛 RT & follow for the chance to win a Lorena Wiebes Yellow Jersey with @SANTINI_SMS. 💛 RT & follow pour tenter de gagner….
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@DerynOLeDuke
Deryn LeDuke
3 years
RT @phdeducations: How to write a research proposal
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@DerynOLeDuke
Deryn LeDuke
3 years
RT @ashleighcycling: Today was a special day! It was everything I hoped it to be and so much more! In the immensity of it all . I managed….
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@DerynOLeDuke
Deryn LeDuke
3 years
RT @ScienceMagazine: Humans consume more pharmaceuticals than ever, which has led to increased pharmaceutical pollution of global ecosystem….
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