David B Sauer
@DavidBSauer
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Membrane Transporters, Ion Channels, Structural Biology, Bioinformatics... and other bits of fun Purdue BS, UTSW PhD, NYUSoM PostDoc, Univ. of Oxford PI
New York, NY
Joined February 2018
Cationic amino acid transport and viral binding of MmCAT1 Fantastic work by @mingda_ye and colleagues at @CmdOxford, @OxfordStrubi, @CAMS_COI_Ox, and the @im2pact_project
https://t.co/5Lw4xZBd9G
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Gluebodies for improved crystal reliability and alternative crystal forms! (also inspiring Di-Gembody for cryoEM) @CmdOxford @FrankvonDelft Now out in ACS Central Science @ACSCentSci Many thank to great supporters! @RosFrankInst @OxfordStrubi @DavidBSauer
https://t.co/7i1gzQS5mG
pubs.acs.org
Design of modular, transferable protein assemblies has broad applicability and in structural biology could help with the ever-troublesome crystallization bottleneck, including finding robustly...
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Closing soon! Please apply if you are interested in targeting membrane proteins with new therapeutics!
Join our group in the Centre for Medicines Discovery at Oxford Univ. @CmdOxford @UniofOxford !!!! Happy to chat about any questions about the role and science. Oxford will assist with a skilled worker visa. Please RT! https://t.co/NPjNkDJ7wU
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Join our group in the Centre for Medicines Discovery at Oxford Univ. @CmdOxford @UniofOxford !!!! Happy to chat about any questions about the role and science. Oxford will assist with a skilled worker visa. Please RT! https://t.co/NPjNkDJ7wU
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I'm far more active on the Bluesky platform, if you want to find me there https://t.co/CruHUNn2s3
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Ugh. In case it wasn't obvious, this account was recently hacked. (Hopefully) now resolved
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First keynote of the day from @DavidBSauer #bcium2025 …before coffee and chocolates from @DECTRIS_News @ccp_em @ccp4_mx @instructhub
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New plan: already delayed flights have no further hiccups AND fast passport control. Trying to be hopeful 😬 Gratitude to @VirginAtlantic customer serv. for coming up with a plan
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@Delta - Yes, we canceled flight but are only codeshare. You need to sort with @VirginAtlantic - Dropped call after 1hr long-distance ($$$) - Also, website is broken loop.
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Another year, another mess with canceled flights. 🤬 @VirginAtlantic - Flight canceled txt, but we'll automatically rebook you. - (I called after silence) We subcontracted the flight; you must sort out with @Delta
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Cheeky visit to @unisabana during a family trip! Spectacular campus in the Colombian Andes Thank you @NuryOlaya2 for a great discussion and showing us around!!
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I should add one great sadness of last year, losing our colleague @sagaraturi An energetic and passionate scientist gone too soon
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And a parallel study on human muscle-type AChR by @RyanHibbs10 and colleagues!! Wonderful to see that we agree on many points, while also making distinct and novel discoveries on AChRs in myasthenia gravis https://t.co/SfRBn3ZzMC
biorxiv.org
Skeletal muscle contraction is mediated by acetylcholine (ACh) binding to its ionotropic receptors (AChRs) at neuromuscular junctions. In myasthenia gravis (MG), autoantibodies target AChRs, disrup...
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Two highlights of 2024 contained in one photo 😀 Titled "First CNS submission of a newborn (aged 4 days)" Alternative title "Type VERY quietly!"
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Very special thanks to @Anna_Liiiiiiii, @mingda_ye, and Ashley for taking on exceptional responsibilities while I was away for muchkin's birth.
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Just finished our "State of the Group" talk in lab meeting 2024 Recap - 9 papers published - 6 papers in review - 2 DPhils What's next - More papers in flight, landing soon - Expand our toolbox and biomed relevance Another year of great pride in our team!
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A fiducial-assisted strategy compatible with resolving small MFS transporter structures in multiple conformations using cryo-EM | Nat Commun https://t.co/9ZrQzmg8Zk
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Now online! @Anna_Liiiiiiii fantastic work on the structure of the Human adult Muscle-type nicotinic receptor. Wonderful collab with @CMS_CDG_Oxford at the @MRC_WIMM and @CmdOxford
https://t.co/WqfsQsj7y8
biorxiv.org
Muscle-type nicotinic acetylcholine receptor (AChR) is the key signalling molecule in neuromuscular junctions. Here we present the structures of full-length human adult receptors in complex with...
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Amazing work capturing NaDC3 in multiple states and with a variety of substrates/inhibitors! Congrats Yan, @danengw, @JoeMindell, and @wjrice_05 !!
Our paper on the reaction cycle of the human dicarboxylate transporter NaDC3 finally came out in @nsmb .
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