Dmitry Veprintsev
@DVeprintsev
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Joined April 2020
PhD projects: 1. characterisation of GPCR variants involved in bleeding disorders. https://t.co/vnoGw12zvI 2)“Transcription programmes that underpin G-protein coupled receptor (GPCR) signalling in lung fibrosis” https://t.co/1y1P6X7SSH dmitry.veprintsev@nottingham.ac.uk
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PhD position: Machine Learning guided design of GPCR ligands with desired pharmacological activity at COMPARE, University of Nottingham. https://t.co/yPXXR9yu6N Deadline 12:00 BST 26.05.2021.
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What makes a GPCR agonist an agonist and antagonist an antagonist? “Prediction of ligand-receptor pharmacological activities using a combined docking and machine learning approach” by Mireia Jimenez-Roses et al. https://t.co/BxLxndF3n7
#GPCR @COMPARE_UoBUoN @DrGPCR
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Diverse chemotypes drive biased signaling by cannabinoid receptors. A set of 35 cannabinoid ligands with full ADME properties dialling the signalling bias in a rheostat-like manner. https://t.co/SPgY3UnMPh
https://t.co/FLuxeBtCQP
@COMPARE_UoBUoN @DrGPCR
veprintsevlab.org
Our latest BioRxiv preprint describing a set of 35 cannabinoid ligands with full ADME properties dialling the signalling bias in a rheostat-like manner. https://doi.org/10.1101/2020.11.09.375162...
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What an odyssey this one has been. Heartfelt thanks to everyone who made it possible @carreiraGroup @DVeprintsev CB2, here we come. Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells
pubs.acs.org
Pharmacological modulation of cannabinoid type 2 receptor (CB2R) holds promise for the treatment of numerous conditions, including inflammatory diseases, autoimmune disorders, pain, and cancer....
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Happy to share our latest ThermoBRET method to measure protein stability in unpurified samples. It is based on BRET between a novel super-stable nanoLuc version and cysteine-reactive fluorescent probes. https://t.co/KecvoWQHFm
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Happy to share our latest ThermoBRET method to measure protein stability in unpurified samples. It is based on BRET between a novel super-stable nanoLuc version and cysteine-reactive fluorescent probes. https://t.co/KecvoWQHFm
biorxiv.org
Sensitive assays to measure the thermostability of membrane proteins are important tools in protein purification optimisation and drug discovery. Here, we present a ThermoBRET method to quantify the...
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Measuring GPCR thermostability in crude lysates - our latest preprint on bioRxiv https://t.co/BGBuTC2gLE
@COMPARE_UoBUoN
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