Dang et al from Vietnam and Australia conducted a retrospective study of subjected aged 18-50 with advanced polyps or colorectal cancer, finding that that siblings of the same age group had a much higher risk of colorectal cancer than did matched controls.

↑ inpatient mortality during all COVID-19 variants except Omicron vs pre-COVID.1.2 ↑ odds of 30-day readmission pre-vaccination vs. pre-COVID.Check out the full article in @DDS_Journal by @2higMD et al here:

Fast forward to 2022, Jens Holst reflects on his pioneering discovery in a fascinating perspective piece.

In 1993, groundbreaking research in DDS unveiled the impact of GLP-1 on human GI functions, redefining our understanding of gastric emptying and more.

Gastroparesis induced by atropine or dopamine worsened NSAID-induced gastric antral ulcer formation in refed mice via enhanced bile reflux via 5-HT3 and dopamine D2 receptors, with the possible involvement of increased duodenal motility.

The prevalence of esophageal inlet patch (IP), a finding of controversial consequence, was reported to be of higher among patients with Barrett’s esophagus (BE) along with pathophysiological similarities of IP and BE, suggesting shared etiology.

Long-standing but not new-onset diabetes is associated with increased mortality among patients with pancreatic cancer. This information has implication for prognostication and risk stratification among pancreatic cancer patients.

Obri et al from Detroit, Michigan, in an analysis of liver center registry data, reported that referral for end-of-life care in patients with advanced, terminal hepatocellular carcinoma were more common among Black than in white patients.

In a longitudinal study of patients diagnosed with celiac disease, Schiepatti et al reported a high rate of persistent symptoms that they attributed to functional disease and not due to dietary indiscretion as they had originally postulated. #OpenAccess.

Pre-procedure knowledge of a positive multi-target stool DNA test improves neoplasia diagnosis rates among colonscopoists with lower baseline adenoma detection rates, independent of withdrawal time @DerekEbnerMD @DrJohnKisiel @MayoClinicGIHep

Levitte et al from Stanford University and Genentech studies the expression of pentraxin-2, an endogenous plasms protein with anti-fibrotic properties in patients with fibrostenotic Crohn’s disease correlating its expression with stenosis.

The optimal time interval between listing and LT to maximize survival in ACLF-3 is unknown. Our study showed that early LT (< 7 days from listing) in ACLF-3 is associated with better 1-year survival compared to late LT (days 8-28 from listing)

Li et al from Nantong, China reported that bromodomain-containing protein 4, a reader of histone acetylation may serve as a biomarker useful in the prediction of severity of esophageal squamous cancer. #OpenAcess.

sST2 may not serve as a valuable biomarker in the diagnosis and treatment of H. pylori infection. Findings are of relevance for further research investigating sST2, as we could not find an influence of asymptomatic H. pylori infection on sST2 concentration.

The chronic use of proton pump inhibitors (PPI) is associated with adverse effects. Ngwenya et al in a study of a Swedish population reported that chronic PPI use is associated with excess all-cause mortality. #SpringerNature.

Sessile serrated polyps are a major contributor to the missed polyp rate. Kono et al from Japan using acetic acid spray and narrow band imaging readily identified these polyps, which in turn may help prevent incident cancers. #SpringerNature.

Simvastatin would reduce cirrhosis severity in Child-Pugh class (CPc) up to B, with a proper basal lipoprotein milieu, and leukocyte reduction. In CPc A would improve health-related quality of life and decrease admissions for decompensated cirrhosis.

McDonnell from the University of Washington in an analysis of 28 children with celiac disease and controls reported that gluten-free products were more likely to contain “food additives of interest” that may impact health. #SpringerNature.

Brechmann and co-workers from Germany studied 45 subjects with gastric inlet patches and laryngopharyngeal symptoms, reporting that laser coagulation of the inlet patches safely relieved symptoms in a majority of their subjects. #SpringerNature.

IgG4 is associated with eosinophilic esophagitis (EoE), but its role in pathogenesis is unclear. We found that food-specific IgG4 levels are increased in the throat, stomach, and duodenum in addition to the esophagus in patients with EoE. #SpringerNature