Covid Analysis: 200+ COVID-19 treatments
@CovidAnalysis
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Real-time analysis of 6,000+ COVID-19 studies for 211 treatments. https://t.co/CjDlaDoPim
Joined June 2020
@MaryanneDemasi @NEJM @RobertKennedyJr @RetsefL @newstart_2024 @maryhollandnyc @weldeiry @Jikkyleaks @jeffreytucker @DrJulieSladden @btysonmd @stkirsch @P_McCulloughMD @Humanspective @ClareCraigPath @DrSuzanneH7 NEJM is also hiding the results of the largest paxlovid trial - PANORAMIC, which shows higher hospitalization/death in the treatment arm, OR 1.18 [0.55-2.62]. The results were online 9/10 showing NEJM acceptance and publication 9/12, but have since been deleted and nothing from
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Our system monitors the registry for new results and we can confirm that unfavorable results are often withheld until just before the deadline. An example from this month with late submission is attached (primary completion February 2024). 351 people risked their life and 29
As I noticed in 2023, when the results of trial are bad, pfizer wait until the very last day to submit the results on https://t.co/pKqTyCrSg4. It happened with PeP paxlovid trial, mRNA covid vaccine on pregnant women, and now again with mRNA flu vaccine. https://t.co/60R0wwcIzu
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The same for https://t.co/P2yxadqw6p
https://t.co/op5s4ZikGJ is open source and free to be used by anyone with no royalty or even acknowledgement required. We just ask that any mistakes be corrected, so that it becomes more objectively accurate over time.
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Always a good day to remember this quote from the former editor of the New England Journal of Medicine, Marcia Angell.
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@RogerSeheult Hydrotherapy/thermotherapy is also effective for COVID-19 although rarely used with only 4 studies using a variety of methods. https://t.co/fFFyjUt1to
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@MaryanneDemasi @NEJM @RobertKennedyJr @RetsefL @newstart_2024 @maryhollandnyc @weldeiry @Jikkyleaks @jeffreytucker @DrJulieSladden @btysonmd @stkirsch @P_McCulloughMD @Humanspective @ClareCraigPath @DrSuzanneH7 NEJM is also hiding the results of the largest paxlovid trial - PANORAMIC, which shows higher hospitalization/death in the treatment arm, OR 1.18 [0.55-2.62]. The results were online 9/10 showing NEJM acceptance and publication 9/12, but have since been deleted and nothing from
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5/ Improved efficacy for manufacturer trials is not new, although the difference is notably large for COVID-19. https://t.co/N2Z4F9lNeL
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4/ Remdesivir approval was based on a government RCT with manufacturer connections (ACTT-1) and two manufacturer RCTs (one without a control group). The government RCT notes regular team calls with Gilead and includes a Gilead co-author. The government (NIAID, CDC, DOD) had
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3/ Molnupiravir approval was based primarily on the manufacturer MOVe-OUT trial. Post-approval review is very limited. The FDA reviewed PANORAMIC and one of the many studies indicating that use creates new variants. They state that the study analyzing new variants "does not
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2/ Paxlovid approval was based primarily on the manufacturer EPIC-HR trial. Post-approval review is very limited. There is no indication that they have reviewed the PANORAMIC results, although they would likely have been available to the FDA in 2024, and partial results were
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🔴 Manufacturer trials of approved COVID-19 treatments show dramatically higher efficacy compared to non-manufacturer trials. Non-manufacturer trials may not be fully independent - authors or organizations may have conflicts with the manufacturer or prior recommendations. 🧵 1/
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More details: https://t.co/cR3dOzM6o0
🔴 PANORAMIC PAXLOVID RESULTS LEAKED - Largest paxlovid RCT shows higher death or hospitalization - 14 vs. 11 events (1,698/1,673 patients) - ~$6.5B revenue during extension/delay period 🧵1/
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🎶 PANORAMIC paxlovid trial - the Broadway musical 🎶 The story of the leaked and deleted results for the largest trial of the world’s #1 COVID-19 treatment - the Oxford PANORAMIC trial. 🔊 Volume up 🔊
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TOGETHER TRIAL paper retracted?! What is this, sanity in academia? It's even weirder because I have written not one but 3 articles on this specific paper. (links below)
🔴 TOGETHER TRIAL RETRACTION The Together Trial COVID-19 metformin paper has been retracted due to impossible data and compromised integrity. The ivermectin paper has not yet been retracted, despite having more serious issues.
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This retraction was delayed over 3 years. Metformin issues and retraction: https://t.co/MT45Ck23g4
https://t.co/v5raeI1bTn
https://t.co/gBmoRHFTrL
https://t.co/s4AmIKioyG Ivermectin issues: https://t.co/S4g7BeHXaX
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🔴 TOGETHER TRIAL RETRACTION The Together Trial COVID-19 metformin paper has been retracted due to impossible data and compromised integrity. The ivermectin paper has not yet been retracted, despite having more serious issues.
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@PGtzsche1 @sudokuvariante @CDCgov @US_FDA @WHO @NIH Prof. Gøtzsche: which trials / reviews do you recommend supporting this viewpoint? Notes on the Cochrane analysis and a comparison with their paxlovid analysis are attached.
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Direct treatment to the primary source of initial infection can minimize transmission and progression. A cascade of potentially severe outcomes can be prevented by halting replication in the upper respiratory tract prior to progression.
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New study: https://t.co/li6K5Jd8V6 All inhaled UFH studies: https://t.co/Sr564Jv3G9 Many respiratory tract treatments show efficacy: https://t.co/iOCPugQSrY
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🟢☠️58% lower COVID-19 mortality with respiratory tract treatment. Meta-trial of 6 RCTs shows significantly lower mortality with inhaled nebulized unfractionated heparin, which has antiviral, anti-inflammatory, and anti-coagulant effects that may minimize viral entry, lung
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