Chia-Lung Hsieh
@ChiaLungHsieh
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A PI @AcadSinica in Taiwan who is obsessed with label-free optical microscopy and nanoscale cell biophysics 😎
Taipei City, Taiwan
Joined November 2018
Just wrapped up a fantastic meeting with the iSCAT community in Taipei, Taiwan—great discussions, insightful exchanges, and genuine camaraderie!
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Cell organelles dynamics recorded by iSCAT using a mercury lamp illumination with a commercial microscope frame.
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What to add iSCAT imaging to a standard epifluorescence microscope? We show how to transform an IRM into an iSCAT by enhancing the illumination coherence of a mercury lamp with this straightforward upgrade.
pubs.acs.org
Interferometric scattering (iSCAT) microscopy is a sensitive optical technique for visualizing nanoscale objects by detecting their elastic scattering through interferometry. iSCAT typically employs...
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We are hosting a Special Symposium on Interferometric Scattering Microscopy in Taiwan, on April 17, 2025, the day after FOM2025 concludes. Registration is required but completely free. Don't miss this chance to explore the latest advancements in iSCAT.
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check out our recent work that integrates correlation spectroscopy and iSCAT for studying chromatin dynamics in 3D without labeling
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I contributed a commentary in Nature Photonics on Philipp Kukura's groundbreaking study on single-protein optical holography. I am looking forward to a wave of innovative research that will enhance the sensitivity and precision of holographic microscopy.
nature.com
Nature Photonics - A non-common-path interferometric scheme enables holographic detection of single proteins of mass 90 kDa and estimation of single-protein polarizability.
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direct visualization of ER network remodeling by iSCAT (label-free!)
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Ultrafast Widefield Mid-Infrared Photothermal Heterodyne Imaging
pubs.acs.org
Mid-infrared photothermal (MIP) microscopy is a valuable tool for sensitive and fast chemical imaging with high spatial resolution beyond the mid-infrared diffraction limit. The highest sensitivity...
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Quantitative amplitude and phase iSCAT imaging for nanoparticles
pubs.acs.org
Interferometric scattering microscopy (iSCAT), the imaging of interference between scattered light from a nanoparticle and reflected light from a substrate, provides a sensitivity sufficient for...
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Enjoy reading @LaurentCognetBx Perspective "On Some Current Challenges in High-Resolution Optical Bioimaging", particularly the views on "Resolution and Specificity in Label-Free Imaging;.toward Functional Imaging."
pubs.acs.org
In this Perspective we propose our current point of view and a suggestive roadmap on the field of high-resolution optical microscopy dedicated to bioimaging. Motivated by biological applications,...
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Reading this BOEx article #OSA_BOEx .Optical Transmission Tomography for label-free cell imaging demonstrated by Boccara group. Brilliant.
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see how a lipid diffuse in the plasma membrane at the nanoscale!
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Heterogeneous nanoscopic lipid diffusion in the live cell membrane and its dependency on cholesterol .Have a look at how a phospholipid diffuse in the plasma membrane at nanoscale!!.
cell.com
Cholesterol plays a unique role in the regulation of membrane organization and dynamics by modulating the membrane phase transition at the nanoscale. Unfortunately, due to their small sizes and...
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Molecularly Specific and Functional Live Cell Imaging by Label-Free Interference Microscopy .have a read of our perspectives on label-free cell imaging with ultra-sensitive interference microscopy! Higher molecular specificity, more functional information!.
pubs.acs.org
Optical interference microscopy is a powerful bioimaging technique by measuring the complex light fields associated with the specimen. Nowadays, the state-of-the-art interference microscopy makes it...
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Label-Free Dynamic Imaging of Chromatin in Live Cell Nuclei by High-Speed Scattering-Based Interference Microscopy .a new method to enhance molecular specificity in label-free imaging.
pubs.acs.org
Chromatin is a DNA–protein complex that is densely packed in the cell nucleus. The nanoscale chromatin compaction plays critical roles in the modulation of cell nuclear processes. However, little is...
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Dynamic signal of live biological cells under interferometric scattering (iSCAT) microscopy and its impacts on single-particle tracking via @IOPscience.
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