Charlie Shi
@CharlieYShi
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Postdoc in the Greenberg Lab at HMS Neurobiology
Somerville, MA
Joined February 2020
Glad to see our work on target-directed miRNA degradation (TDMD) out online – a fun collab with Elena Kingston, @BenKleaveland , Dan Lin, and Michael Stubna!.
science.org
Some microRNA targets trigger proteolysis of Argonaute proteins, allowing the sculpting of specific microRNA levels.
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Generate videos in just a few seconds. Try Grok Imagine, free for a limited time.
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RT @CoffeeBond007: Check out our new paper revealing the context-dependent role of poly(A)-binding protein in coupling poly(A)-tail length….
elifesciences.org
Longer poly(A) tails improve translation in early development, but not in mature cells that have higher levels of the protein PABPC.
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A funny indicator of how my views have evolved since college is going from finding the 'Sokal affair' awesome to finding it cringey, and then back to awesome again but for a different reason.
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Perhaps Said and al-Azm could have benefited from one of those 'how to give and receive feedback' workshops.
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Whether pretextual or earnestly held, the arrogance is astounding and downright ghoulish
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RT @CNBCnow: Pfizer, Biontech, Novavax, Moderna shares plunge to session lows after U.S. backs waiving patent protections on Covid vaccines….
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RT @nytopinion: "We face the very real possibility of affluent countries administering variant-blocking boosters to already vaccinated peop….
nytimes.com
If they keep their vaccine promises, the pandemic can end.
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Interesting points being made, but I wonder if the author largely argues from the consequences because rejecting the substance of Popper's model of science might seem too. Popperian?.
aeon.co
A powerful cadre of scientists and economists sold Karl Popper’s ‘falsification’ idea to the world. They have much to answer for
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Nice piece by Kang – both expansive and deeply personal. In it, a remarkable quote from Yeun: . “Sometimes I wonder if the Asian-American experience is what it’s like when you’re thinking about everyone else, but nobody else is thinking about you.” .
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The arrest of Chen and the ascent of Lander (both MIT professors) in the same week should make us ponder whether it is simply Science that Is Back.
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Attila the Hun? That's some leftward slippage. It's Sauron or bust, friends
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What do you call that feeling where a passage you're reading is gorgeously written and just glows with the promise of profundity, but you're too stupid / dead inside to *really* get it.
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Just realized that in the popular Christmas song Santa Baby, there is the line. "Santa honey, one little thing I really need: The deed to a platinum mine.". Obvi extraction is bad, but honestly props for going big with the ask.
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