Centrosome Papers
@CentrosomePub
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A friendly bot posting centrosome and centriole papers. Automated alter ego of @StearnsLab.
Cytoplasm
Joined May 2020
Paternal Effects in Mammalian Reproduction: Functional, Environmental, and Clinical Relevance of Sperm Components in Early Embryos and Beyond
pubmed.ncbi.nlm.nih.gov
In addition to widely recognized contributions of the paternal genome, centriole, and oocyte-activation factors, sperm deliver a wide range of macromolecules to the fertilized embryo. The impacts of...
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Prenatal bisphenol A exposure causes sperm quality and functional defects via Leydig cell impairment and meiosis arrest in mice offspring
pubmed.ncbi.nlm.nih.gov
Bisphenol A (BPA), widely used in plastic production, acts as an environmental endocrine disruptor which is harmful to male reproductive health. However, the specific mechanisms through which...
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Crosstalk Between Plk1 and PTEN in Mitosis Affects Chromosomal Stability
pubmed.ncbi.nlm.nih.gov
The mitotic phase involves the distribution and regulation of genetic material. Defects in gene regulation can lead to serious errors in genetic transmission, such as increased instability of...
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Centrosome Pre: In vitro approaches to study centriole and cilium function in early mouse embryogenesis
biorxiv.org
Although centrioles and primary cilia play an essential role in early mammalian development, their specific function during the interval between their initial formation and the subsequent arrest of...
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Ninein isoform contributions to intracellular processes and macrophage immune function
pubmed.ncbi.nlm.nih.gov
Ninein is a multifunctional protein involved in microtubule (MT) organization and dynein/dynactin complex recruitment and activation. Several isoforms of ninein have been identified in various...
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Harnessing Structure Prediction of Polo-Like Kinase 4 for Drug Repurposing
pubmed.ncbi.nlm.nih.gov
Polo-like kinase 4 (PLK4) is a centrosome-specific kinase aberrantly expressed in cancers. Drugs inhibiting its catalytic kinase domain are under clinical phase-1/2 trials in patients with different...
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The conserved Spd-2/CEP192 domain adopts a unique protein fold to promote centrosome scaffold assembly
pubmed.ncbi.nlm.nih.gov
Centrosomes form when centrioles assemble pericentriolar material (PCM) around themselves. Spd-2/CEP192 proteins, defined by a conserved "Spd-2 domain" (SP2D) comprising two closely spaced AspM-Spd...
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Structural characterization and inhibition of the interaction between ch-TOG and TACC3
pubmed.ncbi.nlm.nih.gov
The mitotic spindle is a bipolar array of microtubules, radiating from the poles which each contain a centrosome, embedded in pericentriolar material. Two proteins, ch-TOG and TACC3, have multiple...
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Centrobin serves as a safeguard to guide timely centriole maturation during the cell cycle
pubmed.ncbi.nlm.nih.gov
Centrioles assemble and segregate in link to the cell cycle. Daughter centrioles assemble at S phase, and become young mother centrioles after M phase. Since distal appendages (DAs) are installed to...
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Prognostic Value of Centrosome Replication-Related Genes in Prostate Cancer Based on Transcriptomic and Mendelian Randomization
pubmed.ncbi.nlm.nih.gov
Prostate cancer (PCa) is a significant global health concern, with its incidence and mortality rates projected to rise due to population aging. In this study, we utilized PCa transcriptome data from...
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Pericentriolar material 1 aggregation maintains cell survival upon prolonged replication stress
pubmed.ncbi.nlm.nih.gov
The centrosome is essential for maintaining cell shape and facilitating cell division. Thus, precise control of centrosome copy numbers is crucial for proper chromosome segregation. Pericentriolar...
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Asymmetry in centrosome maturation revealed through AIR-1 dynamics in the early Caenorhabditis elegans embryo
pubmed.ncbi.nlm.nih.gov
Centrosomes are critical organelles associated with the nucleus, consisting of a pair of centrioles surrounded by a cloud of pericentriolar material. They serve as key nucleation sites for microtub...
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Construction of a prognostic risk model for clear cell renal cell carcinomas based on centrosome amplification-related genes
pubmed.ncbi.nlm.nih.gov
Clear cell renal cell carcinoma (ccRCC) is the urological malignancy with the highest incidence, centrosome amplification-associated genes (CARGs) have been suggested to be associated with carcinog...
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Structural mechanisms for centrosomal recruitment and organization of the microtubule nucleator γ-TuRC
pubmed.ncbi.nlm.nih.gov
The γ-tubulin ring complex (γ-TuRC) acts as a structural template for microtubule formation at centrosomes, associating with two main compartments: the pericentriolar material and the centriole...
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Anti-Cancer Potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the Centrosome
pubmed.ncbi.nlm.nih.gov
Anaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell lymphoma affecting children and young adults. About 30% of patients develop therapy resistance therefore new precision medicine drugs are...
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Asymmetry of centrosomes in Drosophila neural stem cells requires protein phosphatase 4
pubmed.ncbi.nlm.nih.gov
Asymmetric cell division is used by stem cells to create diverse cell types while self-renewing the stem cell population. Biased segregation of molecularly distinct centrosomes could provide a...
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A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture
pubmed.ncbi.nlm.nih.gov
Centrioles have a unique, conserved architecture formed by three linked, 'triplet', microtubules arranged in ninefold symmetry. The mechanisms by which these triplet microtubules are formed remain...
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Competitive antagonism of KAT7 crotonylation against acetylation affects procentriole formation and colorectal tumorigenesis
pubmed.ncbi.nlm.nih.gov
Accurate procentriole formation is critical for centriole duplication. However, the holistic transcriptional regulatory mechanisms underlying this process remain elusive. Here, we show that KAT7...
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UFMylation Modulates OFIP Stability and Centrosomal Localization
pubmed.ncbi.nlm.nih.gov
OFIP is identified as a novel substrate for UFMylation. UFL1-mediated OFIP UFMylation is essential for its stability and centrosomal localization in HeLa cells. However, these effects are not...
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