In dormancy, paclitaxel and lapatinib barely move the needle. Remove the matrix or block p38 and the cells wake up and respond again. Straightforward, repeatable, and useful for picking winners before in vivo. https://t.co/NYJBcupeIm #hydrogel #3dculture #tumorbiology

#articleoftheweeks Can a simple hydrogel model surface dormancy driven drug resistance? Sarker et al. build a 96 well coculture spheroid that pushes tumor cells into a quiet state with p38 up and ERK down. It is easy to set up and finally shows what 2D screens miss. Link below.

This study demonstrates how live-cell transport can enable distributed and collaborative research across sites. With the Cellbox™ Shipper, a:head bio AG illustrates that even complex 3D brain models can travel safely without compromising function. Keeping life moving wherever

Upon arrival, calcium imaging with a Hamamatsu Photonics Europe platform showed preserved neuronal activity and reproducible compound responses. These findings confirm that brain organoids can be shipped alive and remain ready for immediate functional testing. #neuroscience

To assess how live organoids perform after transport, a:head bio AG used brain organoids expressing the calcium indicator GCaMP. The Cellbox™ Shipper maintained stable temperature and gas conditions during transit, ensuring sample integrity for downstream analysis. #organoids

New #usecase: How resilient are brain organoids after transport? a:head bio AG, a biotechnology company focused on advancing human brain organoid models for neuroscience and drug discovery, tested this using the Cellbox™ Shipper and an Imaging Platform from Hamamatsu Photonics

In our latest blog, we explore how MSCs are shaping the future of cell-based therapies and why their role in modern medicine continues to grow. Read more: https://t.co/vJF05H8d3G #stemcells #mscs #regenerativemedicine #celltherapy #lifesciences

Their strength lies in how they interact with the body. MSCs don't simply replace damaged cells. They guide the healing process and adapt to their environment. That flexibility makes them both powerful and complex.

#CellboxBlog Mesenchymal stem cells, or #MSCs, are gaining attention in regenerative medicine. They support tissue healing, influence immune responses and help reduce inflammation. Still, many in the field underestimate their full potential.

#mythsandreality Without CO₂ regulation, pH and cell environments shift and viability drops. Reliable research starts with how cells are transported. #researchintegrity #celltransport #lifescience #cellculture #biotech

Takeaway: test in 3D and pick the right imaging before you go in vivo. https://t.co/ZuBARsVRwd #spheroids #nanomedicine #drugdelivery #oncology

In a head-to-head, an SN-38 nanocarrier reached the core and matched free drug. A clinical comparator didn’t.

The twist is imaging. Confocal suggests rim-only uptake. Light-sheet at 24 h reveals full penetration. Your modality can flip your conclusion.

Co-culture in 96-well plates recreates hypoxia, dense matrix, and drug resistance. Simple setup, reproducible readouts.

#ArticleoftheWeek Practical 3D spheroids for nanomedicine testing that people can actually run. Yadav, Evtushenko, and colleagues, npj Biomedical Innovations (2025).

This is the story behind Cellbox and the people driving it. 👉Learn more: https://t.co/Eu6wLYfEzw Watch our full film: https://t.co/VvFWMb2OKM #cellbox #biotech #celltherapy

Validated with Fraunhofer IZI Backed by the European Innovation Council Used in over 250 setups across biotech, pharma and research

It works in planes, across borders, through heat and cold. Sensors, software and solid engineering keep conditions constant, even in motion.

With our Cellbox™ incubators, living cells can be shipped without freezing. Under stable, physiological conditions and ready to use when they arrive.

Cell and gene therapies have come a long way. But transporting living cells has been stuck in the past. We’ve built something to change that.