1/10.Larger or high-grade dysplastic distal adenomas found on flexi-sig screening associated with ⬆️ risk of future proximal colon cancer.No associations for # or histology of distal adenomas or any distal hyperplastic polyp characteristics.@BMJOpen_Gastro.

Thrilled to share that Fangqing Li has been awarded a China Scholarship Council @imperialcollege Scholarship!. She'll rejoin CSPRG in July as a fully funded PhD student, focusing on early-onset colorectal cancer. Welcome back, Fangqing! . #PhD #CancerResearch @ImperialSandC

A huge thank you to the 3 brilliant speakers (& their supportive colleagues) from @ImperialNHS, @ImperialSandC who joined @harewoodr for a great PPI session with 58 EKTA Harrow community members. Valuable discussions had on breast & prostate cancer awareness & current research!

More highlights from @CRUKresearch #PrevConf25.☑️Heavyweight (academic) slugfest re GLP-1 agonists (we're calling it a draw).☑️the lowdown on drugs precision prevention from @ProfKarenBrown of @coloprevent

Our Head @DrAmandaJCross & Dep Head @gwenannmurphy busy catching all the action at @CRUKresearch #PrevConf25 and mingling/catching up with #cancerprevention colleagues from @wcrfint @IARCWHO @CaPP3 @AmericanCancer et al

RT @DrPMitrou: Pleasure to meet with @DrAmandaJCross and @gwenannmurphy from @CSPRG_Imperial @wcrfint #PrevConf25

2/10.What. New analyses of #UKFSST data identify distal polyp characteristics associated with future proximal colon cancer risk Funders: @CR_UK @NIHRresearch. Authors: @harewoodr, K Wooldrage, E Robbins,.@bowelsurgeon, @ChrisvonWagner & @DrAmandaJCross

10/10.Summary.Previously unclear if distal polyps associated with proximal colon cancer incidence. We show for 1st time that distal adenoma size & dysplasia was associated with proximal colon cancer risk. No association found for distal hyperplastic polyp characteristics examined.

9/10.Impact. This is the first study to show an association between distal polyp characteristics & long-term proximal colon cancer risk, helping to inform who might benefit from colonoscopy, and providing evidence for future updates of post-polypectomy surveillance guidelines.

8/10.Limitations. Some subgroup sample sizes were small, limiting statistical power. Further large-scale prospective studies or analyses of pooled flexi-sig trials are needed to confirm these results.

7/10.Findings. No clear association between number of distal adenomas or distal adenoma histological type and proximal colon cancer risk. For those with only HPs, there was no evidence that size or number was linked to future proximal colon cancer risk

6/10.Findings. For distal adenomas, larger size & high-grade dysplasia = higher risk of future proximal colon cancer:.-Adenomas 6-9mm vs <5mm = HR 1.67 (1.07–2.59).-Adenomas ≥10mm vs <5mm = HR 2.08 (0.98–4.43).-High grade vs low-grade dysplasia = HR 2.82 (1.34–5.93)

5/10.Methods. Polyp characteristics included:.- Size: <5mm, 6-9mm, >10mm.- Number: 1, 2, >3.- Histology of adenomas: tubular or tubulovillous.- Dysplasia grade of adenomas: low or high grade.

4/10.Methods. 39,539 participants aged 55-64 underwent flexi-sig screening. Of those, we analysed 9,453 with distal polyps found at flexi-sig, split into:.-4581 w/ adenomas +/- hyperplastic polyps (HP).-4872 w/ HPs only.Proximal colon cancer incidence over 21 years of follow up.

3/10.Background. Flexi-sig reduces distal colorectal cancer (CRC) risk but 40% of new CRCs are found in the proximal colon. We examined whether distal polyps detected during flexi-sig screening were associated with proximal colon cancer risk.

RT @imperialcollege: We’ve been named as 1st in the UK and 2nd in the world by QS @worlduniranking! . This recognises Imperial as one of th….

RT @DanRSMiddleton: Great fully funded PhD opportunity to work with me (@CPH_QUB) and @valmacsee (@IARCWHO) on ESCC in Africa. IARC placem….

Wishing a joyful Eid al-Adha to all who are celebrating!.

RT @imperialcollege: We're celebrating Pride Month with the #OurImperial community. Wishing a joyful and empowering month filled with love….

We took a break from the office to celebrate the successful PhD vivas of both Emma and Sharon with a sunny picnic! It was great to have the opportunity to mark this achievement as a group, congratulations to you both!.#PhDone