Clinical Pharmacology & Analytical Chemistry Lab
@CPACLab
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The CPAC Lab, led by Angela Kashuba, former dean of @UNCPharmacy, supports the global #HIV research community through expertise in pharmacology
Joined April 2020
Our research advocating for 2-1-1-1 on-demand PrEP for cisgender women was featured in @BodyPROHIV! Check out Mackenzie Cottrell's interview with commentary from Jenell Stewart @HennepinHC discussing this "exciting step in the right direction" đź”— https://t.co/2NW1b99aag
thebodypro.com
A modeling study predicts that adding a fourth day of on-demand PrEP for people assigned female at birth might maintain protective drug levels for seven days after exposure.
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New from our lab! Adding a 4th day to the on-demand PrEP regimen may boost HIV protection for cisgender women, according to new modeling research. https://t.co/VYpiPHvr0C
#HIVPrevention #PrEP #WomensHealth #UNCPharmacy
academic.oup.com
Using an established pharmacokinetic/pharmacodynamic tissue model of tenofovir disoproxil fumarate/emtricitabine, we predict adding a fourth day of dosing
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🎉 Happy to share that Eli Rosen was awarded an R01! This collaboration with OHSU will benchmark PK for both long-acting and daily ARVs in rhesus macaques and examine how pre-treatment immunopathogenic damage affects ARV tissue penetration https://t.co/Br3Ky31lfq
#HIVResearch
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Our collaboration with University of Colorado compares direct vs. indirect DBS assays for HIV PrEP adherence. We offer guidance for clinical interpretation, including adjustments for sample degradation outside cold-chain. đź”— https://t.co/mduj0dLVM2
#HIVPrevention #PrEP
academic.oup.com
AbstractBackground and Objectives. The active metabolites of HIV pre-exposure prophylaxis (PrEP)—tenofovir-diphosphate and emtricitabine-triphosphate—can b
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Antiretrovirals don’t reach all genital tissues equally—some areas may be underprotected. New imaging from a collaboration with our laboratory reveals why this matters for prevention and cure. #HIVresearch #ARVs #HIVprevention
https://t.co/lRSMHXdf78
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New guidelines from a collaboration with our laboratory improve how we read PrEP drug levels in blood spots—helping ensure people get the protection they need. #HIVprevention #PrEP #Adherence
https://t.co/tUrDGkMhXm
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The HIV PDR is revolutionizing how HIV drug data is shared—making decades of research searchable, standardized, and ready to power the next breakthroughs in treatment and prevention. #HIVresearch #DataSharing Check out our publication here 👉
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#CROI2025 was fantastic! We are incredibly proud of Mackenzie Cottrell and her well-received oral presentation, "Optimizing On-Demand Tenofovir Disoproxil Fumarate/Emtricitabine Dosing in Women for HIV Prevention", which is featured on NATAP! https://t.co/a6lSKo7KWB
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Check out our upcoming abstract presentation when you're at #ASCPT2025!! A Modeling Approach to Expedite the Development of a New Long-Acting Controlled-Release Multipurpose Formulation Containing Medroxyprogesterone Acetate
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📊Long-Acting Injectable CAB/MPA MPT Implant for Prevention of HIV and Unintended Pregnancy
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📊Dose-Ranging Pharmacokinetics and Efficacy of a 90-Day Multipurpose IVR Delivering Islatravir 📊Effect of Antiretroviral Regimen on Contraceptive Failure Among Women Using Injectable Contraception
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📊A Biodegradable Implant Releasing Low-Dose Islatravir Protects Macaques From Rectal SHIV Infection 📊Combination of eCD4-IgG1 Delivered by AAV9 and AZD5582 in SIV-Infected, ART-Suppressed Infant RM
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🎙️Optimizing On-Demand Tenofovir Disoproxil Fumarate/Emtricitabine Dosing in Women for HIV Prevention 🎙️An Injectable Multipurpose Implant With CAB and MPA for Long-Acting HIV Prevention and Contraception 🎙️AZD5582 and Venetoclax Reduce SIV Reservoirs in ART-Suppressed Macaques
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Already looking forward to next year's International Workshop on Clinical Pharmacology of HIV, Hepatitis, and Other Antiviral Drugs! Enduring materials from this year's conference available here: https://t.co/uHZiNvulZA
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Excited to announce our work was nominated for the 2024 Charles C. Shepard Science Awards @CDC! https://t.co/sJ1v5cJ16i
pmc.ncbi.nlm.nih.gov
Ultra-long-acting delivery platforms for HIV pre-exposure prophylaxis (PrEP) may increase adherence and maximize public health benefit. We report on an injectable, biodegradable, and removable...
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Three papers from our lab for your weekend read! 📚 https://t.co/lew0QkWo86
https://t.co/G2kUmWZPBc
https://t.co/MKpCR5ydl8
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We are so proud of Mackenzie Cottrell for her promotion to Associate Professor @UNCPharmacy!! Check out her published works here 👉 https://t.co/PMNBtHr1zQ
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Congratulations @AKashubaUNC for this well-deserved award!!
Congratulations to Dean Angela Kashuba! On Friday evening, she was recognized with the Carolina Alumni Faculty Service Award! The award honors faculty members who have performed outstanding service for @UNC or the alumni association. Read more: https://t.co/AZ7dHt8gX8
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