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Clinical Pharmacology & Analytical Chemistry Lab Profile
Clinical Pharmacology & Analytical Chemistry Lab

@CPACLab

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The CPAC Lab, led by Angela Kashuba, former dean of @UNCPharmacy, supports the global #HIV research community through expertise in pharmacology

Joined April 2020
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
4 days
CPAC Lab holiday fun!!
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
2 months
Our research advocating for 2-1-1-1 on-demand PrEP for cisgender women was featured in @BodyPROHIV! Check out Mackenzie Cottrell's interview with commentary from Jenell Stewart @HennepinHC discussing this "exciting step in the right direction" đź”— https://t.co/2NW1b99aag
thebodypro.com
A modeling study predicts that adding a fourth day of on-demand PrEP for people assigned female at birth might maintain protective drug levels for seven days after exposure.
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
3 months
New from our lab! Adding a 4th day to the on-demand PrEP regimen may boost HIV protection for cisgender women, according to new modeling research. https://t.co/VYpiPHvr0C #HIVPrevention #PrEP #WomensHealth #UNCPharmacy
academic.oup.com
Using an established pharmacokinetic/pharmacodynamic tissue model of tenofovir disoproxil fumarate/emtricitabine, we predict adding a fourth day of dosing
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
3 months
🎉 Happy to share that Eli Rosen was awarded an R01! This collaboration with OHSU will benchmark PK for both long-acting and daily ARVs in rhesus macaques and examine how pre-treatment immunopathogenic damage affects ARV tissue penetration https://t.co/Br3Ky31lfq #HIVResearch
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
4 months
Our collaboration with University of Colorado compares direct vs. indirect DBS assays for HIV PrEP adherence. We offer guidance for clinical interpretation, including adjustments for sample degradation outside cold-chain. đź”— https://t.co/mduj0dLVM2 #HIVPrevention #PrEP
academic.oup.com
AbstractBackground and Objectives. The active metabolites of HIV pre-exposure prophylaxis (PrEP)—tenofovir-diphosphate and emtricitabine-triphosphate—can b
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
5 months
Antiretrovirals don’t reach all genital tissues equally—some areas may be underprotected. New imaging from a collaboration with our laboratory reveals why this matters for prevention and cure. #HIVresearch #ARVs #HIVprevention https://t.co/lRSMHXdf78
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
5 months
New guidelines from a collaboration with our laboratory improve how we read PrEP drug levels in blood spots—helping ensure people get the protection they need. #HIVprevention #PrEP #Adherence https://t.co/tUrDGkMhXm
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
5 months
The HIV PDR is revolutionizing how HIV drug data is shared—making decades of research searchable, standardized, and ready to power the next breakthroughs in treatment and prevention. #HIVresearch #DataSharing Check out our publication here 👉
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
9 months
#CROI2025 was fantastic! We are incredibly proud of Mackenzie Cottrell and her well-received oral presentation, "Optimizing On-Demand Tenofovir Disoproxil Fumarate/Emtricitabine Dosing in Women for HIV Prevention", which is featured on NATAP! https://t.co/a6lSKo7KWB
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
10 months
Check out our upcoming abstract presentation when you're at #ASCPT2025!! A Modeling Approach to Expedite the Development of a New Long-Acting Controlled-Release Multipurpose Formulation Containing Medroxyprogesterone Acetate
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
10 months
📊Long-Acting Injectable CAB/MPA MPT Implant for Prevention of HIV and Unintended Pregnancy
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
10 months
📊Dose-Ranging Pharmacokinetics and Efficacy of a 90-Day Multipurpose IVR Delivering Islatravir 📊Effect of Antiretroviral Regimen on Contraceptive Failure Among Women Using Injectable Contraception
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
10 months
📊A Biodegradable Implant Releasing Low-Dose Islatravir Protects Macaques From Rectal SHIV Infection 📊Combination of eCD4-IgG1 Delivered by AAV9 and AZD5582 in SIV-Infected, ART-Suppressed Infant RM
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
10 months
🎙️Optimizing On-Demand Tenofovir Disoproxil Fumarate/Emtricitabine Dosing in Women for HIV Prevention 🎙️An Injectable Multipurpose Implant With CAB and MPA for Long-Acting HIV Prevention and Contraception 🎙️AZD5582 and Venetoclax Reduce SIV Reservoirs in ART-Suppressed Macaques
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
10 months
We are authors on 8 abstracts at #CROI2025!! Titles for 3 oral 🎙️ and 5 poster 📊 presentations are below
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
1 year
Already looking forward to next year's International Workshop on Clinical Pharmacology of HIV, Hepatitis, and Other Antiviral Drugs! Enduring materials from this year's conference available here: https://t.co/uHZiNvulZA
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
1 year
Three papers from our lab for your weekend read! 📚 https://t.co/lew0QkWo86 https://t.co/G2kUmWZPBc https://t.co/MKpCR5ydl8
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
2 years
We are so proud of Mackenzie Cottrell for her promotion to Associate Professor @UNCPharmacy!! Check out her published works here 👉 https://t.co/PMNBtHr1zQ
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@CPACLab
Clinical Pharmacology & Analytical Chemistry Lab
2 years
Congratulations @AKashubaUNC for this well-deserved award!!
@CarolinaRxStory
Carolina Pharmacy
2 years
Congratulations to Dean Angela Kashuba! On Friday evening, she was recognized with the Carolina Alumni Faculty Service Award! The award honors faculty members who have performed outstanding service for @UNC or the alumni association. Read more: https://t.co/AZ7dHt8gX8
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