Novel machine learning-based tool for screening high-risk varices!.The FIB‑4plus score combines FIB‑4, liver stiffness, & spleen stiffness via machine learning to accurately detect high‑risk varices — effective tool for clinicians. Read more: #LiverDisease

Switching from long-term TDF to besifovir (BSV) showed the non-inferior antiviral efficacy in chronic hepatitis B patients. The improved renal function and bone density was demonstrated after switching to BSV. A promising option to reduce TDF-related side effects!.Read more:

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The Baveno VI-SSM criteria, combining liver and spleen stiffness with platelet counts, can identify more HBV-related cirrhosis patients at very low risk of decompensation than other non-invasive models!.Read more: #Hepatology #LiverCirrhosis

5th Annual International Editorial Board Meeting of CMH. Always a great pleasure to connect with our outstanding editors!.We’re continually inspired by the dedication and insights of our international editorial board. We sincerely appreciate the invaluable suggestions that will

Adverse impact of metabolic dysfunction on fibrosis regression following direct-acting antiviral therapy:.A multicenter study for chronic hepatitis C

Long-term kinetics of plasma pgRNA in patients on NUCs. Plasma pgRNA declines slower than DNA upon NUC therapy. Only 16% patients achieved RNA undetectability after 5 years NUC indicating cccDNA silencing has not been achieved in the majority of patients. Read more:

Integrated multiomics study of sarcomatoid HCC. This study demonstrated a comprehensive description of the molecular basis for sarcomatoid HCC, and identify genomic alteration (ARID2 mutation).together with the tumor microenvironment (hypoxic microenvironment). Read more:

Cost-effectiveness and return on investment of HCV elimination in China. The strategy with an annual primary screening of 14%, re-screening of the PWID every year and the general population every five years, and treatment of 95% of diagnosed patients was the most cost-effective.

Prediction of PBC in AMA-M2 Positive Population. AMA-M2 could be positive in non-PBC individuals. This study showed that ALP, GGT, IgM, eosinophil (%), gamma globulin (%), HGB, and sex were potential variables for prediction of PBC in this population. Read more:

Exciting news! "Clinical and Molecular Hepatology" has achieved a 2024 Impact Factor of 16.9, ranking 6th out of 143 in Gastrenterology & Hepatology. Thank you all for your continued support and contributions. Let’s continue this journey together by advancing knowledge and

TIPS does more than lower portal pressure-it rewires inflammation. In decompensated cirrhosis, TIPS leads to a sustained and significant drop in systemic inflammation and bacterial translocation markers (↓25 SIMs, ↓sCD14, ↓CRP), translating into improved outcomes for patients.

Bariatric surgery improves survival in MASLD and cirrhosis—especially with laparoscopic approach. Bariatric Surgery reduced overall mortality by 37% and liver-related mortality by 76% in patients with MASLD and cirrhosis. Especially Laparoscopic surgery showed greater benefit

A rollover study from the TORCH-B trial:.3-year TDF therapy resulted in favorable histopathological, biochemical, and virological outcomes in CHB patients with minimally raised ALT. 📘 Full article: #ClinicalLiver #ChronicHepatitisB #CHB #HBV #LiverHealth

🧪 Aberrant fragmentomic features of ccf-mtDNA for early detection and prognosis prediction of HCC. This is the first study to explore the clinical application of ccf-mtDNA fragmentomic features in predicting HCC prognosis, highlighting its potential as a blood-based biomarker

In this multicenter, retrospective study including CHC patients who were treated with DAAs and achieved a SVR, metabolic dysfunction has an unfavorable influence on fibrosis regression.

📌 Sex-Specific Gut Microbiota Profiles in MASLD: A Clinical Insight. 🔍 Could sex differences in gut microbiota explain MASLD heterogeneity?.This Clin Mol Hepatol study shows distinct microbial signatures in the jejunum and colon between males and females with MASLD. 🧠 Key

📢 Universal HCV Self-Testing: A new approach to eliminate HCV! 🩸💡. Our latest study shows that universal HCV self-testing is highly cost-effective and can reduce severe liver disease by 71% while preventing 69% of liver-related deaths. A major step toward the WHO 2030

📢 USP29 stabilizes ACSL5 to mitigate MASLD. Our latest study reveals that USP29 protects against MASLD progression by stabilizing ACSL5 through K48-linked deubiquitination. Enhancing the USP29-ACSL5 pathway could be a novel therapeutic strategy for MASLD management. 🔗 Read