NC-MRI demonstrated higher sensitivity and accuracy compared to CECT in detecting recurrent HCC in patients who had been disease-free for over two years following curative treatment, indicating its potential as a preferred imaging modality for this purpose.

The KASL two-step approach is an effective and practical method for risk stratification in patients with MASLD, optimizing patient care through early identification of high-risk individuals.

The burden of alcohol-associated liver disease (ALD) and alcohol-attributable cancers in the US has increased significantly from 2000 to 2021. Females experienced a disproportionate rise in ALD mortality, while primary liver and pharyngeal cancers were the fastest-growing

HTD1801, a novel berberine ursodeoxycholate compound, showed promising histologic improvements in metabolic dysfunction-associated steatohepatitis (MASH) with type 2 diabetes. Preclinical and Phase 2 data revealed significant improvements in liver inflammation, fibrosis, and fat

GLP-1 receptor agonist significantly reduced risks of HCC, cirrhosis, cardiovascular disease, chronic kidney disease, and non-liver cancers in patients with type 2 diabetes and MASLD. Promising evidence for broader protection beyond glycemic control. https://t.co/WOlLMd4wF4

The role of hepatocyte-specific maturation processes in shaping the phenotypic diversity of HCC! The loss of liver-specific metabolism correlates with morphological dedifferentiation, indicating cellular dedifferentiation may exhibit both physiological and pathological duality.

The SAFE score consists of age, BMI, diabetes, AST, ALT, platelet, and globulin. The SAFE score effectively predicts hepatocellular carcinoma (HCC) risk across viral and non-viral chronic liver diseases. Identifying high-risk patients (SAFE score ≥100) was associated with

Novel machine learning-based tool for screening high-risk varices! The FIB‑4plus score combines FIB‑4, liver stiffness, & spleen stiffness via machine learning to accurately detect high‑risk varices — effective tool for clinicians. Read more: https://t.co/Di9btvMHvF #LiverDisease

Switching from long-term TDF to besifovir (BSV) showed the non-inferior antiviral efficacy in chronic hepatitis B patients. The improved renal function and bone density was demonstrated after switching to BSV. A promising option to reduce TDF-related side effects! Read more:

The Baveno VI-SSM criteria, combining liver and spleen stiffness with platelet counts, can identify more HBV-related cirrhosis patients at very low risk of decompensation than other non-invasive models! Read more: https://t.co/qSxDCxN7vS #Hepatology #LiverCirrhosis

5th Annual International Editorial Board Meeting of CMH. Always a great pleasure to connect with our outstanding editors! We’re continually inspired by the dedication and insights of our international editorial board. We sincerely appreciate the invaluable suggestions that will

Long-term kinetics of plasma pgRNA in patients on NUCs Plasma pgRNA declines slower than DNA upon NUC therapy. Only 16% patients achieved RNA undetectability after 5 years NUC indicating cccDNA silencing has not been achieved in the majority of patients. Read more:

Integrated multiomics study of sarcomatoid HCC This study demonstrated a comprehensive description of the molecular basis for sarcomatoid HCC, and identify genomic alteration (ARID2 mutation) together with the tumor microenvironment (hypoxic microenvironment). Read more:

Cost-effectiveness and return on investment of HCV elimination in China The strategy with an annual primary screening of 14%, re-screening of the PWID every year and the general population every five years, and treatment of 95% of diagnosed patients was the most cost-effective.

Prediction of PBC in AMA-M2 Positive Population AMA-M2 could be positive in non-PBC individuals. This study showed that ALP, GGT, IgM, eosinophil (%), gamma globulin (%), HGB, and sex were potential variables for prediction of PBC in this population. Read more:

Exciting news! "Clinical and Molecular Hepatology" has achieved a 2024 Impact Factor of 16.9, ranking 6th out of 143 in Gastrenterology & Hepatology. Thank you all for your continued support and contributions. Let’s continue this journey together by advancing knowledge and

TIPS does more than lower portal pressure-it rewires inflammation In decompensated cirrhosis, TIPS leads to a sustained and significant drop in systemic inflammation and bacterial translocation markers (↓25 SIMs, ↓sCD14, ↓CRP), translating into improved outcomes for patients.

Bariatric surgery improves survival in MASLD and cirrhosis—especially with laparoscopic approach Bariatric Surgery reduced overall mortality by 37% and liver-related mortality by 76% in patients with MASLD and cirrhosis. Especially Laparoscopic surgery showed greater benefit