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Computational Biology Unit led by Prof. Paolo Provero Neurosciences Dept. at @unito Tweets are from lab members.
Torino, Italy
Joined January 2022
New pre-print out! 🎉 With Mathilde + team we traced spatio-temporal shifts in genetically regulated #transcription across 10,000 years of Western Eurasia, fine-mapping regulatory features targeted by #selection! 👉 https://t.co/ihS4OoBats ! #popgen #genomics
biorxiv.org
The genetically regulated component of molecular traits can be imputed from ancient genomes, though low genotyping quality and genetic drift may impair accurate expression prediction and results...
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Polygenic and developmental profiles of autism differ by age at diagnosis https://t.co/dySY2esKqE
nature.com
Nature - A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later,...
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Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions https://t.co/N394FPqLRl
nature.com
Nature Genetics - Multiancestry fine-mapping of brain protein quantitative trait loci coupled with Mendelian randomization analyses identifies protein–trait pairs consistent with causal...
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Multiple overlapping binding sites determine transcription factor occupancy https://t.co/MPpJBM0uJJ
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Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci https://t.co/jabIyNhJ3q
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The Importance of Regulatory Network Structure for Complex Trait Heritability and Evolution https://t.co/t3PYJCaEwa
academic.oup.com
Abstract. Complex traits are determined by many loci—mostly regulatory elements—that, through combinatorial interactions, can affect multiple traits. Such
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Whole-genome sequencing of 490,640 UK Biobank participants https://t.co/RLdEtyrR0h
nature.com
Nature - A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human...
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Single-cell eQTL mapping of human endogenous retroviruses reveals cell type-specific genetic regulation in autoimmune diseases https://t.co/IraqNNEJOq
nature.com
Nature Communications - Human endogenous retroviruses are abundant in the genome but poorly characterised. Here, the authors map their expression and genetic regulation in immune cells and identify...
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Towards improved fine-mapping of candidate causal variants https://t.co/Af4p41osxf
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Our work on the molecular basis of the genetic correlation between BMI and brain morphology has now appeared in PLOS Genetics https://t.co/PlaRBctiaG Thanks to @DFusco17, @CamillaMarinel8, @MathildeAndr11, @LuciaTroiani, Martina Noè, and @FabrizioPi1139
journals.plos.org
Author summary Obesity is linked to many chronic diseases and its prevalence worldwide is increasing. Susceptibility to obesity is known to be due, to some degree, to genetic factors, and such...
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Genetically regulated eRNA expression predicts chromatin contact frequency and reveals genetic mechanisms at GWAS loci https://t.co/CWb1QAyRyr
nature.com
Nature Communications - Here, the authors present trained models of genetically regulated enhancer RNA expression, finding that genetically regulated expression predicts chromatin contact frequency...
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An atlas of single-cell eQTLs dissects autoimmune disease genes and identifies novel drug classes for treatment https://t.co/xyuBC5sons
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Plasma proteome variation and its genetic determinants in children and adolescents https://t.co/qhKw6YkmA9
nature.com
Nature Genetics - This mass spectrometry-based proteomic study profiles the plasma proteome in 2,147 children and adolescents and reveals its association with age, sex, puberty, body mass index and...
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