Brian Clark
@Brian_S_Clark
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Assistant Professor, WashU Department of Ophthalmology and Department of Developmental Biology
St Louis, MO
Joined May 2016
Congrats to Tim Lee (@ApteLab) and Jade Enright (Clark lab) on their @WustlDOVS Winston Award Fellowships! Fantastic research updates by all. Thank you to the Winston family for their generous donations in support of our trainees!
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RT @IPalazzo7: Had the best time at #GRCVisualSystems in beautiful Tuscany with Blackshaw lab members past and present! @NguyetLe_ @Brian_S….
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RT @MacDonald_Lab: “The retina through the life course”. An amazing symposium by incredibly talented scientists. Thank you for coming to @U….
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RT @MacDonald_Lab: We’re excited to share our most recent paper where we adapted the IBEX technique to label every cell type in the retina.….
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… tools to study protein-RNA interactions and additional characterizations of lncRNA function in the regulation of retinal development and animal behavior, hopefully in the not too distant future.
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The work on Evf2 (and lncRNAs) continues an intellectual curiosity, seeking to understand the functions of RNA transcripts independent of protein coding potential. We continue to work in this space, both within the developing forebrain and retina. Be on the lookout for new….
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The killifish study represents a previously unfamiliar research topic for me… transcriptional homeostasis and aging. This also introduced me to both a new research model and evolutionary adaptations (diapause and fast-aging/senescence) that ensure fitness of a species.
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The second is a decades long interest in understanding the mechanisms by which lncRNAs, (specifically Evf2) regulate RNA-protein-DNA interactions in control of gene expression in collaboration with my post-bac mentor Jhumku Kohtz.
biorxiv.org
During mouse embryonic brain development, the Evf2 ultraconserved enhancer (UCE) lncRNA guides the Dlx5/6UCE to ∼129 sites across chr6. However, previous work identified only 4 transcriptionally...
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Two new preprints from the lab this week. The first, a collaboration with @LabMoons, @MacDonald_Lab, and @phruzycki (led by @StevenBergmans and @NCLNoel) examining how gene expression changes with age in the fast-aging killifish model.
Interested in how the vertebrate retina ages? Check our latest pre-print: "Age-related dysregulation of the retinal transcriptome in African turquoise killifish". A great collab by: @StevenBergmans @NCLNoel @ArckensLab @phruzycki @phruzycki @MacDonald_Lab @Brian_S_Clark
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RT @LabMoons: On the #ARVO2023 program today:.Go check out poster n° B0053, where @StevenBergmans will amaze you with the retinal landscape….
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and/or reply in the comments. I am happy to talk further about our journey and will relay the worldwide support for my daughter and her continued fight. #shareyourspare.
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Today, I am attending #ARVO2023 wearing this shirt, taking pictures with friends and colleagues that have supported me and my daughter through our journeys. If you see me in this shirt, come say hi, introduce yourself, let’s talk science (I study retinal development)…
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Kidney Transplant, receiving my kidney. Today marks the 4-year anniversary of her transplant and I’m happy to report she is doing great! I am donning a special shirt today to show my pride and support for my daughter’s journey.
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April 18th-24th is pediatric transplant awareness week. A short thread… as many of my friends and colleagues know, my daughter was born with chronic kidney disease during the last year of my PhD training. One year after becoming faculty in WUSTL DOVS, my daughter underwent a….
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