David Brayden
@BraydenDavid
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Full Professor of Advanced Drug Delivery at University College Dublin
Joined February 2012
We have a new paper out with @GattefosseGroup collaborators on Capryol 90 as an intestinal permeation enhancer. Free full text:
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We have a new paper out in JCR with the University of Louvain in which UCD played a small part. Title: "An in situ bioadhesive foam as a large intestinal delivery platform for antibody fragments to treat inflammatory bowel disease".
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We have a new Open Access paper out from our Gattefosse collaboration in Int. J. Pharm: "LabrafacTM MC60 is an efficacious intestinal permeation enhancer for macromolecules: comparisons with Labrasol® ALF in ex vivo and in vivo rat studies"
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We've a new open access paper out in ACS Applied Materials & Interfaces. "Reproducible Synthesis of Biocompatible Albumin Nanoparticles Designed for Intra-articular Administration of Celecoxib to Treat Osteoarthritis." doi/10.1021/acsami.4c02243. @CURAMdevices; @UCD_Conway
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I am hiring a Postdoc to work on a 2-year industry-funded on intestinal permeation enhancers for fluxes of macromolecules. Ex vivo and in vivo GI bioassays will be used: Job post 016909 on the @ucddublin website https://t.co/HnvZxI8hIM.
@UCD_Conway Closing date Feb 16.
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We have a new open-access review out in ADDR on the safety of oral surfactants in dosage forms.
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https://t.co/73AWH3S1vV I have a new review article out in March Issue of American Pharmaceutical Review.
americanpharmaceuticalreview.com
Oral administration of peptides for systemic delivery offers convenience for patients and promotes better adherence to dosing regimens than injections. While this may seem obvious in principle, the...
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I co-authored a just-published review with FDA authors and others on excipients in oral delivery systems
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I have 2 fully-funded PhD posts available each for 4 years advertised on: https://t.co/oxfgz6waEj. One is on buccal delivery of peptides and the other is on an anti-inflammatory nanoparticle for arthritis. Funded by SFI CURAM Centre for Medical Devices. Closing date: July 15.
findaphd.com
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Delighted to be awarded a grant (PEPDELIVER) on oral insulin delivery from the Shared Island "North-South" grant initiative with co-applicant Prof Helen McCarthy (QUB) and collaborator Prof Nick Dunne (DCU) .@njdunne_lab, @DCUBiodesign @Prof_H_McCarthy, @pHionTx, @UCD_Research
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We have a new open-access review in oral peptide delivery from food sources out in Biomedicine and Pharmacotherapy, written with Nuritas Ltd. https://t.co/vzH59TxAqs.
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New Open Access review article out in Frontiers in Drug Delivery. The Centenary of the Discovery of Insulin: An Update on the Quest for Oral Delivery
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Our latest Open Access paper is out in Expert Opinion in Drug Delivery. We did a technological evaluation of Chiasma's MYCAPSSA, (oral octreotide) where we know a bit about the formulation. Copies available at:
tandfonline.com
The FDA approval of oral semaglutide for type 2 diabetes (2019) and oral octreotide for acromegaly (2020) is evidence that selected niche peptides can be administered orally if formulated with sele...
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Happy to work with @scipod_social on this, a professional podcast to achieve further outreach for our research papers. @CURAMdevices @ucddublin #scicomm
Professor David J. Brayden @ucddublin is dedicated to enhancing the oral delivery of peptides. His team are conducting cutting edge research on the effects of specific sugar-based monoesters as intestinal permeation enhancers: https://t.co/cuy1Pf54Tm
#scicomm
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Our new paper "Synthesis and In Vivo Evaluation of Insulin-Loaded Whey Beads as an Oral Peptide Delivery System" by Joanne Heade et al is published today in Pharmaceutics and the Open Access text is available at:
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We have a new open-access paper on sugar esters as intestinal permeation enhancers published in IJP by McCartney, F et al. with great collaborators from Urbino and Nottingham.
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We have a new paper on bile salts as intestinal and buccal permeation enhancers just published in EJPS. Work was drawn from the UCD PhD of Vivien Stuettgen. Full versions of paper at:
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My group has a new Open Access paper out in EJPS with collaborators from the Galien Institute and Sanofi on comparing permeation enhancers, SNAC and C10, in isolated intestinal tissue and gut sacs. Link to full paper:
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I have a new Commentary on the career of Per Artursson out in a JPS Special Issue. 50 free copies.
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We have a new Open Access review out on formulation and medicinal chemistry for oral peptide delivery in 2020 Special Issue of Advanced Drug Delivery Reviews.
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