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BioLizard

@BioLizard_nv

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A bioinformatics and AI company providing innovative solutions for all your scientific data needs.

Joined July 2019
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@BioLizard_nv
BioLizard
2 days
Today's #interestingread examines the performance of AI in predicting the effects of gene perturbation using single-cell data. ๐Ÿ’ก ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™จ๐™ฉ๐™ช๐™™๐™ฎ:
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nature.com
Nature Methods - The analysis presented in this Brief Communication shows that, despite their complexity, current deep learning models do not outperform linear baselines in predicting gene...
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@BioLizard_nv
BioLizard
13 days
๐ŸฆŽ ๐—Ÿ๐—ฒ๐—ฎ๐—ฑ ๐˜๐—ต๐—ฒ ๐—ช๐—ฎ๐˜† ๐—ถ๐—ป ๐——๐—ฎ๐˜๐—ฎ-๐——๐—ฟ๐—ถ๐˜ƒ๐—ฒ๐—ป ๐——๐—ถ๐˜€๐—ฐ๐—ผ๐˜ƒ๐—ฒ๐—ฟ๐˜†!. Weโ€™re on the hunt for a ๐—ง๐—ฒ๐—ฎ๐—บ ๐—Ÿ๐—ฒ๐—ฎ๐—ฑ ๐—ถ๐—ป ๐——๐—ฎ๐˜๐—ฎ ๐—ฆ๐—ฐ๐—ถ๐—ฒ๐—ป๐—ฐ๐—ฒ to help shape the future of innovation at BioLizard. If youโ€™re ready to lead, letโ€™s talk ๐Ÿ‘‰
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@grok
Grok
4 hours
Join millions who have switched to Grok.
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@BioLizard_nv
BioLizard
16 days
Today's #interestingread spotlights ๐—š๐—ฒ๐—ป๐—ฒ๐—”๐—ด๐—ฒ๐—ป๐˜, an AI-powered language agent designed for gene-set analysis. ๐Ÿ’ก ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™จ๐™ฉ๐™ช๐™™๐™ฎ:
nature.com
Nature Methods - GeneAgent is a language agent using large language models and self-verification to improve gene-set function annotation.
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@BioLizard_nv
BioLizard
21 days
๐ŸฆŽ ๐—ช๐—ฒโ€™๐—ฟ๐—ฒ ๐—ต๐—ถ๐—ฟ๐—ถ๐—ป๐—ด! Weโ€™re looking for a Marketing coordinator to help us amplify our impact at the intersection of science and strategy. Join the best minds in data-driven life sciences! ๐Ÿš€ Apply now!
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@BioLizard_nv
BioLizard
23 days
In our #interesting read today, researchers, using in situ cryoโ€‘electron tomography across four mammalian cell lines, found hemifusomes at the cell periphery, making up ~10% of vesicular organelles. ๐Ÿ”ฌ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™–๐™ง๐™ฉ๐™ž๐™˜๐™ก๐™š:
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nature.com
Nature Communications - Cryo-ET reveals hemifused vesicles containing a hemifusion diaphragm and an associated proteolipid nanodroplet. These hemifusomes drive intraluminal vesicle biogenesis and...
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@BioLizard_nv
BioLizard
1 month
This #interestingread presents a benchmark for 40 single-cell multi-modal integration algorithms involving modalities of DNA, RNA, protein and spatial omics for paired, unpaired and mosaic datasets. ๐Ÿ’ก ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™–๐™ง๐™ฉ๐™ž๐™˜๐™ก๐™š ๐™๐™š๐™ง๐™š:
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nature.com
Nature Methods - This Registered Report presents a comprehensive benchmarking analysis of single-cell multi-modal data-integration methods.
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@BioLizard_nv
BioLizard
1 month
Today's #interestingread takes a look at ๐—˜๐˜ƒ๐—ถ๐—ฑ๐—ฒ๐—ป๐—ฐ๐—ฒ ๐—”๐—ด๐—ด๐—ฟ๐—ฒ๐—ด๐—ฎ๐˜๐—ผ๐—ฟ, a generative AI tool for ๐—ฟ๐—ฎ๐—ฟ๐—ฒ ๐—ฑ๐—ถ๐˜€๐—ฒ๐—ฎ๐˜€๐—ฒ ๐—ฑ๐—ถ๐—ฎ๐—ด๐—ป๐—ผ๐˜€๐—ถ๐˜€. ๐Ÿ’ก ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™ฅ๐™ง๐™š๐™ฅ๐™ง๐™ž๐™ฃ๐™ฉ ๐™๐™š๐™ง๐™š:
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@BioLizard_nv
BioLizard
1 month
Our #interestingread for today is all about advancing biological language modeling!. ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™–๐™ง๐™ฉ๐™ž๐™˜๐™ก๐™š ๐™ฉ๐™ค ๐™š๐™ญ๐™ฅ๐™ก๐™ค๐™ง๐™š ๐™ฉ๐™๐™š ๐™›๐™ช๐™ฉ๐™ช๐™ง๐™š ๐™ค๐™› ๐™—๐™ž๐™ค๐™ก๐™ค๐™œ๐™ž๐™˜๐™–๐™ก ๐™ก๐™–๐™ฃ๐™œ๐™ช๐™–๐™œ๐™š ๐™ข๐™ค๐™™๐™š๐™ก๐™ž๐™ฃ๐™œ:
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nature.com
Nature Machine Intelligence - He and colleagues develop LucaOne, a biological foundation model pre-trained on nucleic acid and protein sequences from 169,861 species. It shows an emerging...
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@BioLizard_nv
BioLizard
2 months
๐ŸŒŸ Today's #interestingread dives into the world of single-cell RNA sequencing! This study evaluates the practical aspects and performance of various commercial single-cell RNA sequencing technologies. ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™–๐™ง๐™ฉ๐™ž๐™˜๐™ก๐™š:
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biorxiv.org
The rapid development of updated and new commercially available single-cell transcriptomics platforms provides users with a range of experimental options. Cost, sensitivity, throughput, flexibility,...
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@BioLizard_nv
BioLizard
2 months
Curious how AI is unlocking the secrets of our genome? ๐Ÿงฌ Todayโ€™s #interestingread looks at ๐—”๐—น๐—ฝ๐—ต๐—ฎ๐—š๐—ฒ๐—ป๐—ผ๐—บ๐—ฒ. ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™–๐™ง๐™ฉ๐™ž๐™˜๐™ก๐™š:
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deepmind.google
Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function โ€” now available via API.
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@BioLizard_nv
BioLizard
3 months
Today's #interestingread introduces ๐˜€๐—ฐ๐—ฃ๐—ฅ๐—œ๐—ก๐—ง, a model that leverages transformer-based architecture to infer gene regulatory networks from single-cell data. ๐Ÿ”— ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™–๐™ง๐™ฉ๐™ž๐™˜๐™ก๐™š:
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nature.com
Nature Communications - Authors present a state-of-the-art cell foundation model trained on 50โ€‰million cells. They show that the model generates a meaningful gene network and has zero-shot...
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@BioLizard_nv
BioLizard
3 months
Mondays are for #interestingreads! ๐—–๐—ผ๐—ฑ๐—ผ๐—ป๐—ง๐—ฟ๐—ฎ๐—ป๐˜€๐—ณ๐—ผ๐—ฟ๐—บ๐—ฒ๐—ฟ, a context-aware neural network, addresses the complexities of codon usage bias and provides a versatile tool for synthetic biology. ๐Ÿ”— ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™จ๐™ฉ๐™ช๐™™๐™ฎ:
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nature.com
Nature Communications - Authors report a codon language representation and a model, CodonTransformer, open access and with a user-friendly interface. CodonTransformer generates species-specific DNA...
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@BioLizard_nv
BioLizard
3 months
Todayโ€™s #interestingread dives into how ๐—ฒ๐—ป๐˜€๐—ฒ๐—บ๐—ฏ๐—น๐—ฒ ๐—บ๐—ฎ๐—ฐ๐—ต๐—ถ๐—ป๐—ฒ ๐—น๐—ฒ๐—ฎ๐—ฟ๐—ป๐—ถ๐—ป๐—ด ๐—บ๐—ผ๐—ฑ๐—ฒ๐—น๐˜€ can supercharge the analysis of complex biological systems by integrating multi-omics data. ๐ŸŒฑ๐Ÿงฌ. ๐Ÿ’ก ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™–๐™ง๐™ฉ๐™ž๐™˜๐™ก๐™š:
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@BioLizard_nv
BioLizard
3 months
Time for another #interestingread! This study introduces the ๐— ๐—œ๐—–๐—ฟ๐—ข๐—ก๐—ฆ functional connectomics dataset that intricately maps the functional and structural connectivity of the mouse visual cortex. ๐Ÿ’ก ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™–๐™ง๐™ฉ๐™ž๐™˜๐™ก๐™š:
nature.com
Nature - Dense calcium imaging combined with co-registered high-resolution electron microscopy reconstruction of the brain of the same mouse provide a functional connectomics map of tens of...
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@BioLizard_nv
BioLizard
4 months
Our #interestingread for today explores a breakthrough at the intersection of ๐—”๐—œ ๐—ฎ๐—ป๐—ฑ ๐˜€๐—ฝ๐—ฎ๐˜๐—ถ๐—ฎ๐—น ๐—ฏ๐—ถ๐—ผ๐—น๐—ผ๐—ด๐˜†. ๐Ÿ’ก ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™–๐™ง๐™ฉ๐™ž๐™˜๐™ก๐™š:
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@BioLizard_nv
BioLizard
4 months
Today's #interestingread explores how ๐—˜๐—ฝ๐—ถ๐˜๐—ต๐—ฒ๐—น๐—ถ๐—ฎ๐—น-๐˜๐—ผ-๐— ๐—ฒ๐˜€๐—ฒ๐—ป๐—ฐ๐—ต๐˜†๐—บ๐—ฎ๐—น ๐—ง๐—ฟ๐—ฎ๐—ป๐˜€๐—ถ๐˜๐—ถ๐—ผ๐—ป (๐—˜๐— ๐—ง). ๐Ÿ’ก ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™–๐™ง๐™ฉ๐™ž๐™˜๐™ก๐™š:
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nature.com
Nature - Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and...
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@BioLizard_nv
BioLizard
4 months
Our # interestingread today is about the validation of ๐—ง๐˜‚๐˜๐—ถ๐˜ƒ๐—ถ๐—ฎโ„ข, a risk assessment tool to ๐—ฝ๐—ฟ๐—ฒ๐—ฑ๐—ถ๐—ฐ๐˜ ๐—ฒ๐—ฎ๐—ฟ๐—น๐˜† ๐—ฎ๐—ฐ๐˜‚๐˜๐—ฒ ๐—ฟ๐—ฒ๐—ท๐—ฒ๐—ฐ๐˜๐—ถ๐—ผ๐—ป (๐—”๐—ฅ) in kidney transplant recipients. ๐Ÿงฌ๐Ÿฉธ. ๐Ÿ“– ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™–๐™ง๐™ฉ๐™ž๐™˜๐™ก๐™š:
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@BioLizard_nv
BioLizard
4 months
Today's #interestingread delves into the intricate world of microglia, the brain's resident immune cells, and their diverse roles in development, maintenance, and disease. ๐Ÿ’ก ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™–๐™ง๐™ฉ๐™ž๐™˜๐™ก๐™š:
nature.com
Nature Neuroscience - Microglia have key roles in CNS development and neurodegeneration. Here, the authors provide an overview of microglia heterogeneity, cell-state annotation and model systems.
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@BioLizard_nv
BioLizard
5 months
The Human BioMolecular Atlas Program (HuBMAP) is advancing the creation of a comprehensive 3D Human Reference Atlas (HRA) to map the healthy adult human body. ๐Ÿ’ก ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™–๐™ง๐™ฉ๐™ž๐™˜๐™ก๐™š:
nature.com
Nature Methods - This Resource describes data, code and tools developed for the Human Reference Atlas and the Human BioMolecular Atlas Program for building and navigating a multiscale human atlas.
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@BioLizard_nv
BioLizard
5 months
Today's #interestingread explores ๐—™๐—ฆ-๐—ฃ๐—Ÿ๐—ฆ, a new method that identifies minimal biomarker signatures from clinical omics data without needing library size normalization. ๐Ÿ’ก ๐™๐™š๐™–๐™™ ๐™ฉ๐™๐™š ๐™›๐™ช๐™ก๐™ก ๐™–๐™ง๐™ฉ๐™ž๐™˜๐™ก๐™š:
journals.plos.org
Author summary High-throughput sequencing technologies are widely used in clinical studies to measure expression levels of many thousands of different types of molecules in order to develop improved...
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