Berkeley Genomics Project
@BerkeleyGenomic
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Unlock the promise of safe, accessible, powerful germline genomic engineering. Book: "Methods for strong human germline engineering" https://t.co/GBOjkvX0nB
Berkeley, CA
Joined December 2024
Essay: Discussion: Reading on Sunday, 12:00 PM Pacific time (roughly 50 min), followed by discussion / Q&A:
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As usual, public discussion of reprogenetics brings up many risks and critiques that I agree with--but is still morally deranged because it begins and ends with vague negativity. Wise, life-affirming bioethics requires comparing likely costs and benefits!.
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For better or for worse, trying to understand the world by believing in accordance with hype does not work very well.
Short Sleep Variants Do Not Replicate. In March Kristjan Moore from deCODE genetics emailed me urging me to stop working on short sleep. I read paper in question since Jan, but was still hoping/coping that maybe NPSR1 variant (not included in the paper) would replicate.
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Health is wealth, as they say. So widely distributing health is widely distributing wealth. Far from increasing inequality, reprogenetic technology can be one of the most democratic technologies ever--if we don't restrict it to only rich people who can fly to an island somewhere.
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@CavazzaLab @SchuhLab And if you think of cells as bags of water + diffusion--check out S6 :) Just look at those microtubules. That link again:
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"Parental genome unification is highly error-prone in mammalian embryos"--some amazing work by Tommaso Cavazza et al. at the Melina Schuh lab. @CavazzaLab @SchuhLab . What happens in the first 24 hours after an egg is fertilized? The parental genomes
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Chromosome selection on natural gamete DNA. is it possible?? (Answer: No. But maybe. )
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New essay: "Genomic emancipation". What's the vision motivating reprogenetic technology? My simple answer is genomic emancipation:. Empowering parents to make genomic choices on behalf of their future children. I'll read out the main part of the essay on Sunday, +Q&A. Links⬇️
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* Understanding public interest in reprogenetics.* Understanding the regulatory landscape around reprogenetics.* Educating the public about reprogenetics. Read more about these projects here:
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A few projects you might find interesting and that might help a bit to build the reprogenetics field:.* Submit deregulation suggestions.* Iterated selection scheduling simulations.* Can genomic vectoring have large effects?.* Power of recombinant chromosome selection.1/2.
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RT @hsu_steve: This meeting at Lighthaven has convinced me that both artificial wombs and gene editing of human embryos using stem cell tec….
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RT @LauraMinquini: “The case for germline gene correction: state of the science”. @PaolaAmato .Aleksei Mikhalchenko Ph.D. Shoukhrat Mitalip….
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RT @KianSadeghi5: Longevity is now for embryos. Nucleus Embryo is the first-ever genetic optimization software that helps parents give the….
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This image elides a whole bunch of complexity, detail, and uncertainty. More detail here:. and even more here:.
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A schematic peek into the future of reprogenetics.
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RT @athena_DAO_: Lighting interview with Dr. Paula Amato @PaolaAmato on the Superbaby. AthenaDAO Student Fellowships for @BerkeleyGenomic….
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RT @BerkeleyGenomic: @iaratweet @GeneSmi96946389 In general, usually slippery slopes are actually terraced slopes. It's possible to fall do….
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RT @BerkeleyGenomic: @JeremiahEnglan5 @GeneSmi96946389 I agree that on balance it's not enough of a reason to forego the benefits. But it's….
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