Mehdi Beniddir
@BeniddirM
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Professor of natural products chemistry @UnivParisSaclay @BioCIS. Discovery of unprecedented natural products. Exobiology lover @mehdibeni.bsky.social
Paris
Joined August 2012
Thank you for highlighting our work: MS2DECIDE
đ€ Un logiciel d'IA en accĂšs libre pour faciliter la dĂ©couverte de nouvelles molĂ©cules Cet outil pourrait transformer la recherche de nouvelles molĂ©cules, et pourrait ĂȘtre adaptĂ© aux besoins de chaque laboratoire. Plus d'informations ⶠhttps://t.co/B9cyEyw4bS
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Read this #preprint on @researchsquare: Discovery of Novel Anticancer Agents and Influenza Potential Biomarkers Through a Mass Spectrometry Foundation Model
researchsquare.com
Metabolomics, using non-targeted tandem mass spectrometry, generates rich biological data, but novel metabolites with structures absent from databases are challenging to analyze. Existing algorithms...
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A great innovation in the interface between mathematicians and chemists from @BioCIS with the support of the CNRS ! @CNRSchimie @UnivParisSaclay @LAMSADEDauphine @Paris_Dauphine @CNRSinformatics
https://t.co/FBcw4jVhNZ
inc.cnrs.fr
Un nouvel outil informatique basĂ© sur lâapprentissage permet de repĂ©rer plus rapidement des molĂ©cules encore inconnues dans des ext
What a relief! Finally, MS2DECIDE is no longer a preprint @ChemRxiv It has just been published @ChemMethods
https://t.co/u2X9f2k6lU
@BioCIS @UnivParisSaclay @LAMSADEDauphine @Paris_Dauphine @CNRSinformatics @CNRS #DECISIONTHEORY #DECISIONMAKING #EXPERTKNOWLEDGE #PRIORITIZATION
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Explainable Analysis for New Psychoactive Substance Identification with Chemical Insights #machinelearning #compchem
pubs.acs.org
The emergence of new psychoactive substances (NPS) poses a significant challenge to global public health due to their structural diversity and rapid evolution. Traditional detection methods, such as...
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Why Do Filamentous Actinomycetota Produce Such a Vast Array of Specialized Metabolites? https://t.co/l8gNtBsLTg
annualreviews.org
Bacteria of the phylum Actinomycetota are extremely diverse: They inhabit niches ranging from soils and ocean sediments to the normal human microbiota, and they cause tuberculosis, one of the most...
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Discovery and Biosynthetic Interrogation of a Cobalt-Containing Terpene-Polyketide-Nonribosomal Peptide Tribrid with Anticoronavirus Activity | Journal of the American Chemical Society
pubs.acs.org
The structural complexity of natural products arises from the complexity of their biosynthetic pathways and directly contributes to their biological activities. Guided by this principle, we screened...
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NMRMind: A Transformer-Based Model Enabling the Elucidation from Multidimensional NMR to Structures | Analytical Chemistry
pubs.acs.org
Nuclear magnetic resonance (NMR) data provides rich quantum information on molecular structure, which is closely related to chemical structure and widely used for structural characterization in...
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Functional and Structural Studies on the Esperamicin Thioesterase and Progress toward Understanding Enediyne Core Biosynthesis | Journal of Natural Products
pubs.acs.org
Enediynes are among the most potent antitumor and antibacterial natural products. Studies on their biosynthetic pathways have identified a shared, linear polyene precursor generated from an iterative...
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Thrilled to share with you a recent work from our group supervised by Pierre Le Pogam and conducted by Adrien Jagora: Computational Mass Spectrometry-Based Reassessment of European Amanita sect. Phalloideae Cyclopeptidome | Journal of Natural Products
pubs.acs.org
An advanced metabolomic workflow featuring expert knowledge-tailored mass spectral queries and multi-informative molecular networking was applied to French DNA-barcoded collections of Amanita species...
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Discovery of Antivirulence ClpP Inhibitors by SelfâResistance GeneâGuided Mining Coupled with Dual Functional Screening - Wang - Angewandte Chemie International Edition - Wiley Online Library
onlinelibrary.wiley.com
Streptoclipamide A, a potent ClpP inhibitor (IC50Â =Â 480Â nM), was discovered by self-resistance-guided genome mining coupled with dual functional screening. It uniquely suppresses MRSA virulence...
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"Rapid Construction of a Tyr C6âTrp C5âČ Linkage: Application in the Total Synthesis of Micitide 982, a Noncanonical Cyclic Peptide" appearing today in @angew_chem : https://t.co/gor5aJdB8S Collaboration with @nagata_yuuya @MatsudaLab
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Thrilled to share with you our recent review on the Scalability of MS-based metabolomics for extracts libraries @NatProdReports
https://t.co/cjrCm96LLR It was fun to share this experience with @Adafede @bittremieux @rschmid1789 Olivier Cailloux @LAMSADEDauphine @vdHooft_CompMet
pubs.rsc.org
Covering: up to 2025This review explores the potential of bioinformatics and chemoinformatics tools to advance the exploration of natural extracts libraries (NELs). Although metabolomics has become a...
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What a relief! Finally, MS2DECIDE is no longer a preprint @ChemRxiv It has just been published @ChemMethods
https://t.co/u2X9f2k6lU
@BioCIS @UnivParisSaclay @LAMSADEDauphine @Paris_Dauphine @CNRSinformatics @CNRS #DECISIONTHEORY #DECISIONMAKING #EXPERTKNOWLEDGE #PRIORITIZATION
chemistry-europe.onlinelibrary.wiley.com
Tandem mass spectrum to decision (MS2DECIDE) leverages decision theory and expert knowledge to aggregate the outputs of three widely used annotation tools (GNPS, Sirius, and ISDB-LOTUS) and compute...
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Targeted discovery of sesquiterpene indole alkaloids from Greenwayodendron suaveolens
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A cartoon by Amy Hwang. #NewYorkerCartoons See more from this weekâs issue: https://t.co/c1W76Tb7rX
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https://t.co/clOyicYyIq happy to finally see this work published @OrgChemFront @BioCIS @UnivParisSaclay @ErwanPoupon @LeblondAxel
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We are delighted to report the chemoenzymatic total synthesis of (â)-13-deoxytetrodecamycin which features a biocatalytic intramolecular [4 + 2]-cycloaddition catalysed by Diels-Alderase TedJ. https://t.co/AeiUbQWV0M Have a read in @ChemicalScience !
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Increasing the Scale of the Mass Spectrometry Query Language Compendium with Explainable AI | Analytical Chemistry
pubs.acs.org
A significant bottleneck in metabolomics data interpretation is the effective use of domain knowledge to assign structural information based on fragmentation patterns. The mass spectrometry query...
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