Benji Woolf
@BarWoolf
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Perplexed sceptic & genetic epidemiologist @mrc_ieu @MRC_BSU @BristolUniPsych. Tutor @LSHTM & @StEdmundsCam.
Joined November 2017
One of my students @StEdmundsCam has a really remarkable story of overcoming adversity to study @Cambridge_Uni. Sadly his scholarship can't fund the rest of his degree so he is trying crowdfunding. Any help would be really appreciated, thank you very much!
gofundme.com
Hello, I am Chan Hyuk Park from South Korea, and studying mathematic… Chanhyuk Park needs your support for I may have grown up poor, but my dreams never were.
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RT @stevesphd: New pre-print online: "Context-stratified Mendelian randomization: exploiting regional exposure variation to explore causal….
arxiv.org
Mendelian randomization (MR) uses genetic variants as instrumental variables to make causal claims. Standard MR approaches typically report a single population-averaged estimate, limiting their...
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RT @stevesphd: @BarWoolf Forgot to add the link to the manuscript:
academic.oup.com
Abstract. Mendelian randomization (MR) makes causal claims by treating genetic variation in an analogous way to randomization in a clinical trial. MR inves
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RT @stevesphd: New paper published at AJE Advances: "The role of estimation in Mendelian randomization: should Mendelian randomization inve….
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Posting a tad late, but @jamesyrmsk and @dpsg108 and I have a new research letter in @intjepidemiol where we use negative controls to illustrate why drug use phenotypes should not be used as exposures in MR studies
academic.oup.com
An increasingly common application of Mendelian randomization (MR) in pharmacoepidemiology explores the effects of medication use on drug safety or repurpo
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RT @Danielle_Newby: 🚨 New preprint awaiting feedback! 🚨 led by the lovely and talented @martaalcalde18 looking at the relationship between….
medrxiv.org
INTRODUCTION While preclinical studies suggest that Phosphodiesterase 5 (PDE5) inhibition may reduce cognitive impairment, findings from observational studies on whether PDE5 inhibitors reduce...
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And the accepted m/s is now out in the AJE! Thank you to @htcronje @dpsg108 @stevesphd @LoukasZagkos @LarssonSC Summary can be found
academic.oup.com
Abstract. Mendelian randomization is an epidemiologic technique that can explore the potential effect of perturbing a pharmacological target. Plasma caffei
Had a lot of fun presenting our work (accepted this week at the AJE) on exposure miss-identification in MR, and how it results in directionally incorrect conclusions for studies of caffeine consumption at #mrconf24.
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really enjoyed watching this seminar by @HarvardEpi on measurement error. Lots of food for thought.
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Our new study with James Perry, Charles Hong @mark_toshner, @stevesphd, @dpsg108, Martin Wilkins, and Chris Rhodes failed to find evidence supporting the use of IL6R inhibitors on pulmonary arterial hypertension.
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RT @BMCMedicine: New Mendelian Randomization from @LoukasZagkos @htcronje @BarWoolf @stevesphd @Yuan_AS @LarssonSC @jotzou @dpsg108 et al.:….
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RT @megukepi: **Flash Talks Event** Benjamin Woolf @BarWoolf shares his research "Comparison of caffeine consumption behavior with plasma c….
meg-uk.org
Showcase your molecular epidemiology research in a 3 minute video for a chance to win a prize.
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RT @stevesphd: New paper: "A frequentist test of proportional colocalization after selecting relevant genetic variants": .
arxiv.org
Colocalization analyses assess whether two traits are affected by the same or distinct causal genetic variants in a single gene region. A class of Bayesian colocalization tests are now routinely...
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Really nice review by @htcronje and @stevesphd on the importance of sensible variant selection in MR.
Our review "Incorporating biological and clinical insights into variant choice for Mendelian randomisation: examples and principles" written together with @htcronje and published at @eGastro_BMJ is now available at Brief thread:.
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RT @bmj_latest: New study supports the potential for PDE5 inhibition to increase the number of children fathered by male patients, but find….
bmj.com
Objective To investigate the association of genetically proxied (using a surrogate biomarker) inhibition of phosphodiesterase 5 (PDE5), an established drug target for erectile dysfunction, with...
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RT @stevesphd: Do biological mechanisms leading to penis stiffening make men happy? Do they make them more fertile? Find out in our new dru….
bmj.com
Objective To investigate the association of genetically proxied (using a surrogate biomarker) inhibition of phosphodiesterase 5 (PDE5), an established drug target for erectile dysfunction, with...
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RT @stephensenn: Excellent talk. Thanks for sharing. One of the nice things about RCTs is that you only have to adjust for confounding in w….
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RT @JonathanCiofani: Out now in AJC ⬇️. Raising important questions about possible ancestry-specific CV disease aetiologies in East Asian a….
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