BK Channel Bot
@BK_Papers
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#PubMed Bot tweeting all papers on BK Channels. Please point out any missed papers to be retweeted.
Joined February 2019
I am a bot that tweets papers about BK Channels. Let me know if I miss anything! .#ionchannel #ionchannels #BPS19 #biophysics #biochemistry #MolecularBiology #Genetics.
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A targeted, low-throughput compound screen in a Drosophila model of neurofibromatosis type 1 identifies simvastatin and BMS-204352 as potential therapies for autism spectrum disorder (ASD). eNeuro. #ionchannels.
pubmed.ncbi.nlm.nih.gov
Autism spectrum disorder (ASD) is a common neurodevelopmental condition for which there are no pharmacological therapies that effectively target its core symptomatology. Animal models of syndromic...
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Awakening Allies for Breaking Microenvironment Barriers: NIR-II Guided Orthogonal Activation of Tumor-Infiltrating Mast Cells for Efficient Nano-Drug Delivery. Advanced healthcare materials. #ionchannels.
pubmed.ncbi.nlm.nih.gov
Mast cells (MCs), powerful immune cells that heavily infiltrate cancer cells, play a crucial role in tumor formation. Activated MCs can release histamine and a family of proteases through degranula...
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Dynamin-independent CaV 1.2 and KCa 1.1 channels regulation and vascular tone modulation by the mitochondrial fission inhibitors dynasore and dyngo-4a. European journal of pharmacology. #ionchannels.
pubmed.ncbi.nlm.nih.gov
A role for mitochondrial fission in vascular contraction has been proposed based on the vasorelaxant activity of the dynamin (and mitochondrial fission) inhibitors mdivi-1 and dynasore. However,...
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Targeting colonic BK channels: A novel therapeutic strategy against hyperkalemia in chronic kidney disease. Nefrologia. #ionchannels.
pubmed.ncbi.nlm.nih.gov
Targeting colonic BK channels: A novel therapeutic strategy against hyperkalemia in chronic kidney disease
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Pharmacological Evidence Suggests That Slo3 Channel Is the Principal K+ Channel in Boar Spermatozoa. International journal of molecular sciences. #ionchannels.
pubmed.ncbi.nlm.nih.gov
Sperm ion channels are associated with the quality and type of flagellar movement, and their differential regulation is crucial for sperm function during specific phases. The principal potassium ion...
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Ultrasonic Vibration-Assisted Stamping of Serpentine Micro-Channel for Titanium Bipolar Plates Used in Proton-Exchange Membrane Fuel Cell. Materials (Basel, Switzerland). #ionchannels.
pubmed.ncbi.nlm.nih.gov
Metallic bipolar plates (BPPs) are key components in the proton-exchange membrane fuel cell (PEMFC), which can replace traditional fossil fuels as a kind of clean energy. However, these kinds of...
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Investigation of Program Efficiency Overshoot in 3D Vertical Channel NAND Flash with Randomly Distributed Traps. Nanomaterials (Basel, Switzerland). #ionchannels.
pubmed.ncbi.nlm.nih.gov
The incremental step pulse programming slope (ISPP) with random variation was investigated by measuring numerous three-dimensional (3D) NAND flash memory cells with a vertical nanowire channel. We...
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Effect of Anionic Polyacrylamide Polymer on Frost Heave Mitigation and Its Implication for Frost-Susceptible Soil. Polymers. #ionchannels.
pubmed.ncbi.nlm.nih.gov
Seasonally frozen ground regions occupy approximately 55% of the exposed land surface in the Northern Hemisphere, and frost heave is the common global problem in seasonally frozen soil areas. Frost...
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Peroxisome Deficiency in Cochlear Hair Cells Causes Hearing Loss by Deregulating BK Channels. Advanced science (Weinheim, Baden-Wurttemberg, Germany). #ionchannels.
pubmed.ncbi.nlm.nih.gov
The peroxisome is a ubiquitous organelle in rodent cells and plays important roles in a variety of cell types and tissues. It is previously indicated that peroxisomes are associated with auditory...
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A double-channel multiscale depthwise separable convolutional neural network for abnormal gait recognition. Mathematical biosciences and engineering : MBE. #ionchannels.
pubmed.ncbi.nlm.nih.gov
Abnormal gait recognition is important for detecting body part weakness and diagnosing diseases. The abnormal gait hides a considerable amount of information. In order to extract the fine, spatial...
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Vasorelaxant property of 2-phenyl ethyl alcohol isolated from the spent floral distillate of damask rose (Rosa damascena Mill.) and its possible mechanism. Journal of ethnopharmacology. #ionchannels.
pubmed.ncbi.nlm.nih.gov
The spent flowers of R. damascena, which remain after the extraction of REO, could be used to extract PEA. The PEA possessed marked vasorelaxation properties in both aorta and mesenteric artery and...
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Trace amine-associated receptor 1 regulation of Kv1.4 channels in trigeminal ganglion neurons contributes to nociceptive behaviors. The journal of headache and pain. #ionchannels.
pubmed.ncbi.nlm.nih.gov
These results suggest that tyramine induces Kv1.4-mediated IA suppression through stimulation of TAAR1 coupled to the Gβγ-dependent PKCθ signaling cascade, thereby enhancing TG neuronal excitability...
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Downregulation of ciRNA-Kat6b in dorsal spinal horn is required for neuropathic pain by regulating Kcnk1 in miRNA-26a-dependent manner. CNS neuroscience & therapeutics. #ionchannels.
pubmed.ncbi.nlm.nih.gov
The ciRNA-Kat6b/miRNA-26a/Kcnk1 pathway in dorsal horn neurons regulates the development and maintenance of neuropathic pain, ciRNA-Kat6b may be a potential new target for analgesic and treatment...
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BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site. The Journal of general physiology. #ionchannels.
pubmed.ncbi.nlm.nih.gov
The large-conductance, Ca2+-, and voltage-activated K+ (BK) channel consists of the pore-forming α (BKα) subunit and regulatory β and γ subunits. The γ1-3 subunits facilitate BK channel activation by...
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Blockade of Kv7 channels reverses the inhibitory effects of EPAC activation on purinergic contractions of the murine detrusor. Basic & clinical pharmacology & toxicology. #ionchannels.
pubmed.ncbi.nlm.nih.gov
Purinergic contractions of the detrusor are reduced by cAMP, but the underlying mechanisms are unclear. We examined the effects of BK and Kv7 channel modulators on purinergic contractions of the...
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Sweetening K-channels: what sugar taught us about permeation and gating. Frontiers in molecular biosciences. #ionchannels.
pubmed.ncbi.nlm.nih.gov
Because they enable for the modification of both viscosity and osmolarity, sugars have been used as a biophysical probe of voltage-gated K-channels for a while. Viscosity variations made it possible...
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Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer's disease patients. Nature aging. #ionchannels.
pubmed.ncbi.nlm.nih.gov
Genome-wide association studies have demonstrated that polygenic risks shape Alzheimer's disease (AD). To elucidate the polygenic architecture of AD phenotypes at a cellular level, we established...
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Membrane protein isolation and structure determination in cell-derived membrane vesicles. Proceedings of the National Academy of Sciences of the United States of America. #ionchannels.
pubmed.ncbi.nlm.nih.gov
Integral membrane protein structure determination traditionally requires extraction from cell membranes using detergents or polymers. Here, we describe the isolation and structure determination of...
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GPU-specific algorithms for improved solute sampling in grand canonical Monte Carlo simulations. Journal of computational chemistry. #ionchannels.
pubmed.ncbi.nlm.nih.gov
The Grand Canonical Monte Carlo (GCMC) ensemble defined by the excess chemical potential, μex , volume, and temperature, in the context of molecular simulations allows for variations in the number of...
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Diethylcarbamazine elicits Ca 2+ signals through TRP-2 channels that are potentiated by emodepside in Brugia malayi muscles. bioRxiv : the preprint server for biology. #ionchannels.
pubmed.ncbi.nlm.nih.gov
Filarial nematode infections are a major health concern in several countries. Lymphatic filariasis is caused by Wucheria bancrofti and Brugia spp. affecting over 120 million people. Heavy infections...
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