In my view, a truly exciting, new development in the difficult search for drugs that strengthen cognition and ameliorate memory loss. https://t.co/VuQxAiiaag

People differ significantly in their memory performance. A research team led by @quervain_de & @AndreasPapasso1 has now discovered that certain brain signals are related to these differences. 🧵👇1/8 https://t.co/Aor6Mm93Wq

Wow... 80% of genes are differentially expressed in living versus post-mortem prefrontal cortex tissue. Importantly implications for studying the 'living' biology of the human brain, rather than heavy reliance on what post-mortem tissue shows us.

Diversity as a leitmotiv at the AD/PD opening meeting conference! 😂

3. No, this is not a breakthrough. Claims that this study is even a proof for the efficacy of anti-amyloid treatments are either profit-oriented, or simple-minded, or both.

2. Most importantly: The rates of decline tend to converge (NOT diverge) after 15 months, which is not what you would expect from a disease-modifying drug. Cholinesterase inhibitors show identical slopes with one difference: greater efficacy.

1. Unfortunately, overall rather disappointing results from the CLARITY trial (#Lecanemab in early Alzheimer's disease), despite the profit-oriented hype by the manufacturing company et al. We are talking about a 1.4 points difference between drug and placebo on a 90point scale.

Gilt das auch für Blockaden von Bauern, wenn diese gegen Verschärfung der Klimaziele demonstrieren??? Aktionen von Klimaaktivisten: Union fordert Freiheitsstrafen von mindestens drei Monaten bei Straßenblockaden https://t.co/VUOE6sDJ41 via @derspiegel

With a super exciting lineup of keynote speakers: @GoshenInbal @ClopathLab @Franklandlab @okaysteve @t_bonhoeffer @thephelpslab, @AndreasPapasso1 @lab_fischer, Katharina Henke, Cristina Alberini, and David Dupret. Registration will open soon! 🧠⬇️⬇️⬇️

🚨paper alert🚨 New role for the human cerebellum: much more than muscle control, balance and movement.

https://t.co/7m9qXkB62z

Ein Podcast über kindliche Amnesie. Manchmal kriegen sich Neurowissenschaften und Psychologie in die Haare… Das sind good news für die Wissenschaft.

New publication! The International Society of Psychiatric Genetics (ISPG) issued a statement last year, urging caution on the new technology of polygenic embryo screening. In a commentary for The Lancet Psychiatry, we present a detailed review/explanation. https://t.co/jgiWmOt5NF

Strategie, Bundesrat??

🚨Preprint alert🚨Pharmacological inhibition of a protein that actively promotes forgetting improves memory and age-dependent memory decline in C elegans. Importance of this mechanism in human to be studied. STAY TUNED

A truly elegant piece of work on the role of KIBRA in learning and memory! Congratulations to the team @rhuganir @Dr_Weinberger on combining evidence from rodent and human research and on interpreting #GWAS data.

Anti-amyloid antibody fails in carriers of amyloid-producing mutations.. Sad news for patients and caregivers. How long will it take to learn from the constant failures of anti-amyloid treatment (#aducanumab) and invest in alternate molecular paths? https://t.co/vN5IaDGX2E

ARD Beitrag über unsere aktuelle Forschung zu den Mechanismen des Vergessen und Menschen, die nicht vergessen können. Zusammen mit @quervain_de https://t.co/PKrFx8eM0p

I love the Russian people. That is why I have to tell you the truth. Please watch and share.

WIESO? Wieso verurteilen @CH_universities die “militärische Intervention”? Wieso wird nicht der "völkerrechtswidrige Angriff" Russlands auf die Ukraine verurteilt? Words matter, das wissen @CH_universities ganz genau. Nein, das ist keine scharfe Verurteilung, das ist schwach.