The glut of lipid blobs spotted in activated microglia isn’t just for looks. The depots are essential for all manner of microglial responses. @NIH

Plasma p-tau217 peaks at birth, according to new research. Levels in newborns surpass even those of people with Alzheimer’s. @goteborgsuni

Largest-ever tau-PET studies confirm ties between tangles and cognitive decline. ApoE4 carriers and women get tangles earliest. @_michael_scholl @AlexisMoscoso9 @amsterdamumc

Proteomic studies of CSF and brain tissue find distinct features of #alzheimersdisease in Down’s syndrome compared with EOAD and LOAD. @EmoryMedicine @nyugrossman @IIBSantPau

In the oldest old, a hefty load of amyloid plaques spells poorer cognition, but other types of neuropathology play a part, too. @amsterdamumc

ApoE has a new partner. Once endocytosed, it hands off its lipid cargo to TTYH2, a lipid binding protein found in endosomes.

In a large study of three cohorts, scientists found that CSF α-synuclein assays not only diagnose Parkinson’s disease with high sensitivity, but also predict who will develop dementia—and how quickly. @UCLIoN

Are T cells in the brain friend or foe? In tauopathy mice, CD8⁺ T cells can slow pathology. In older, wild-type mice, they damage the optic nerve. (@NINDSnews @NIH @tumuenchen

Subcellular proteomics reveals how #alzheimersdisease affects the myelin-axon interface. Spoiler alert: AD promotes aberrant signaling that likely dampens synaptic transmission. @Yale

To fuel the relentless demands of synaptic transmission, neurons tap little fat stores within their synapses. @WeillCornell

Angiotensin converting enzyme kicks microglia into hyperdrive, boosting their ability to clear plaques in a mouse model of Alzheimer’s disease. @Cedars-Sinai

Scientists found a novel amyloid fibril, Aβ42 Type III, in brains extracts from a man who had AD. It contains three, not two, protofilaments. @sjtu1896

With 40,000 blood and CSF samples, the GNPC’s neurodegeneration proteomics dataset is the largest disease-specific effort yet. #alzheimersdisease @_neuroproteome

The ultra-sensitive NULISA protein assay can detect #alzheimersdisease by analyzing blood. It may aid differential diagnosis and prognosis. @BarcelonaBeta @wustl @Cambridge_Uni @UWMadison @goteborgsuni @PittTweet

An H. pylori protein, CagA, blocks amyloidogenic fibrilization across a broad range of pathogenic proteins, highlighting potential therapeutic applications. @karolinskainst

A longitudinal biomarker study in Down’s syndrome adults identifies plasma p-tau217 as a key measure of dementia risk. @lunduniversity @NIHAging

In mice, regular workouts spur neurogenesis, as well as transcriptomic changes across cell types. Exercise also corrected some signatures of AD. @MassGeneralNews .

A strong immune system may be key to preventing Alzheimer’s disease. People with higher titers of anti-viral antibodies were less likely to have dementia. @NIHAging

New entry route to the brain uncovered. Scientists identify a previously unrecognized pathway that myeloid cells use to infiltrate the CNS.

T helper cells derived from gut and fat tissue travel to the brain, where they play a homeostatic role in governing feeding behavior. @Yale