"Although administering antivenoms remains essential in managing some snake envenomations, clinicians practicing in a-GAL endemic regions may wish to exercise increased vigilance and prepare for adverse drug reactions and anaphylaxis, especially when treating patients with a.

"In conclusion, our findings demonstrate a high rate of adverse drug reactions and presumed anaphylaxis to crotaline antivenoms in an area where a-GAL IgE sensitization is common. ".3/.

"These data suggest that exposure to a-GAL antigen in the bloodstream (through intravenous injection) could cause anaphylaxis, even when oral exposure to red meat does not occur.".2/.

Prevalence of Adverse Drug Reactions: Comparing Crotalidae Immune Polyvalent Antivenoms F(ab')2 and F(ab) in a Galactose-alpha-1,3-galactose (alpha-gal) Endemic Area.1/.

RT @OFIDJournal: A Review of Alpha Gal Syndrome for the Infectious Diseases Practitioner. ✅ Just Accepted.🔗 https:/….

"Our findings support pre-treatment alpha-gal screening to improve safety of cetuximab therapy in high-risk populations.".

"The possible production of alpha-gal by tsetse flies was also investigated. Considering the diversity in clinical presentations in response to arthropod bites.".4/4.

"For future research, larger epidemiological studies and citizen science initiatives should be conducted and complemented by detailed investigations into biological mechanisms of AGS and pathways of vector-borne sensitization.".3/.

"Herein, we report several cases of allergic reactions linked to tsetse bites from the Diptera order, particularly the Glossinidae family, and explore the potential role of these species in sensitization to alpha-Gal.".2/.

Allergic reactions associated with tsetse fly bites.1/.

The Immunology of Alpha-Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat (review article).

"Evidence supporting the possibility of a new adverse event, TRAGS, is accumulating. This study quantifies how often Group O patients may be exposed to Group B antigen in Group B or AB plasma and/or platelet transfusions, providing an estimate of the scope of potential risk for.

"The primary goal of this study was to assess the frequency of Groups B and AB plasma and platelet transfusions to Group O patients.".3/.

"Recent case reports of severe allergic transfusion reactions (ATRs) in Group O patients receiving Group B plasma and platelets raise the possibility of a new adverse event, herein called transfusion-related AGS (TRAGS).".2/.

ABO-mismatched platelet and plasma transfusion practices and the potential for transfusion-related alpha-gal syndrome: The Biomedical Excellence for Safer Transfusion Collaborative Study.1/.

"It is very interesting how the prevalence of AD among elderly residents in the USA and the prevalence of anti-αGal IgE production in patients with αGal syndrome (AGS) involve the same geographical areas. This aspect could strengthen the link between anti-αGal antibodies and.

". Conversely, a provocative hypothesis is that antibodies cross-reacting with brain GLSs in AD might arise via the sensitization to alpha- Gal-epitopes contained in gut microbiota or tickborne antigens .".3/.

"These findings suggest a disease-specific binding pattern of anti-αGal antibodies to gangliosides in the AD brain, supporting their potential role as diagnostic biomarkers.".2/.

Anti-Alpha-Gal Antibodies Against Gangliosides: A New Autoimmune Target in Alzheimer’s Disease Patients. 1/.

"With research in other medical fields suggesting complications with use of bovine and porcine derived implants, it is imperative that further research be done into the safety and efficacy of these implants, particularly in connective tissue augments and bioprostheses, in the.