ADAPT-Sepsis
@AdaptSepsis
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Biomarker-guided duration of antibiotic treatment for sepsis
NIHR HTA commissioned trial
Joined November 2018
Primary outcome @UKCCRGroup @AdaptSepsis . Safe reduction in antibiotics @DarkNatter #UKCCRF25
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Delighted to have the chance to address important international discussions about @AdaptSepsis
jamanetwork.com
In Reply We designed the ADAPT-Sepsis trial1 as a superiority study, addressing a prioritized research funding brief2 and international evidence gaps.3 Our sample size estimate, type I error rate,...
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Editor’s choice from the February 25 issue. ➡️ Camrelizumab With Chemotherapy in Patients With Early or Locally Advanced TNBC ➡️ Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis ➡️ Essential Thrombocythemia: A Review; and more.
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@WICSBottomLine @hqva Thank you for this detailed review and comments. We @AdaptSepsis are working on trial process evaluation and health economic outcomes right now, so more to come to aid understanding of results. Hopefully, we will see you all @ICS_updates events in 2025 for further discussions
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1/ Delighted to report the results of the Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH) trial in @LancetChildAdol
thelancet.com
In children with suspected or confirmed bacterial infection admitted to hospitals in England and Wales for intravenous antibiotic treatment of at least 48 h, the introduction of a procalcitonin-gui...
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A major UK patient trial of a new biomarker testing protocol for sepsis, led by @OfficialUoM researchers, has shown it is possible to safely stop antibiotic treatment earlier than current care 🔬 @FBMH_UoM @DarkNatter Read more about the trial 👇 https://t.co/0w0WKwcivz
manchester.ac.uk
A major UK patient trial of a new biomarker testing protocol for sepsis, led by University of Manchester researchers, has shown it is possible to safely stop antibiotic treatment earlier than current...
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@darknatter presents the results of the @AdaptSepsis trial results earlier today at @CCRdownunder The paper has been published in @JAMA_current
https://t.co/BK8lAqLFXd
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Chief Investigator @darknatter shares the findings from the #ADAPTsepsistrial at #CCRdownunder
@adaptsepsis @FBMH_UoM @NIHRresearch @EPPiC_Warwick @NCAresearchNHS @JAMA_current
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We are delighted to have contributed to this important trial. Because clinical research is how we improve the care we deliver. Thank you to our patients who took part. @AdaptSepsis @NCAresearchNHS @DarkNatter
Published in JAMA with #CCRdownunder: In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein. @CritCareReviews
https://t.co/j6v8imY0AX
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Fantastic work led by @darknatter and delivered by the phenomenal UK Critical Care community. We can safely reduce antibiotic duration using procalcitonin (but not CRP). @AdaptSepsis @WarwickCTU
Published in JAMA with #CCRdownunder: In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein. @CritCareReviews
https://t.co/j6v8imY0AX
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We're delighted to announce @AdaptSepsis as our first trial result presentation at #CCRdownunder ADAPT-Sepsis is a 2760 patient RCT investigating biomarker-guided duration of antibiotic therapy in patients with sepsis To be presented by @DarkNatter
https://t.co/b4KzFpBA2r
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From Belfast to Melbourne - CCR Down Under is coming The Best Critical Care Trials in the World #CCRdownunder
https://t.co/VXLd1WDL9H
@intensiveblog @precordialthump @KBibbinsDomingo @giovannilandoni @GiacomoMonti @BaiardoMartina @anzicsctg @chodgsonANZICRC @DogICUma
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Thrilled to hear that the @AdaptSepsis team have reached their recruitment target - well done everyone! We're looking forward to comparing our process evaluation findings with your trial results in the coming months!
cedar.nhs.wales
Thank you to patient participants, families and carers for their generosity in taking part in the @AdaptSepsis research trial. We will now work hard with sites and investigators to complete data collection and report results as soon as possible @NCAresearchNHS @WCTU @FBMH_UoM
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@DarkNatter @AdaptSepsis @NCAresearchNHS @WCTU @FBMH_UoM Congratulations, Paul, looking forward to the results!
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Great work to all involved in completing recruitment to the @AdaptSepsis study. Thank you to our research team for their hard work in recruiting 85 of the number below! @NCAresearchNHS @OldhamCO_NHS
Thank you to patient participants, families and carers for their generosity in taking part in the @AdaptSepsis research trial. We will now work hard with sites and investigators to complete data collection and report results as soon as possible @NCAresearchNHS @WCTU @FBMH_UoM
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@DarkNatter @AdaptSepsis @NCAresearchNHS @WCTU @FBMH_UoM Incredible work by @AdaptSepsis team and @DarkNatter !
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@DarkNatter @AdaptSepsis @NCAresearchNHS @WCTU @FBMH_UoM Fantastic achievement 👏 Looking forward to the results and how they will guide AMS practice in the critically ill
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