Silvia von Karstedt
@vonKarstedtLab
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Biology first, music secondđź‘Ś #CancerResearch #lungcancer #CellDeath #Ferroptosis
Cologne, Germany
Joined April 2020
Fantastic work by @vonKarstedtLab and @LiccardiLab Ibrutinib sensitises to Ferroptosis #dlbcl #ferroptosis #btk #ibrutinib
https://t.co/n6lCsnmFmP
nature.com
Cell Death Discovery - Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL)
Thrilled to share our latest paper in Cell Death Discovery! 👉 https://t.co/Ohd2eYMyqE Together with my fantastic co-senior and co-corresponding author @vonKarstedtLab , we uncovered that the BTK inhibitor ibrutinib has a previously unrecognized role in disrupting redox balance
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A paper for #Halloween. Equally thrilled to have this work out in lightning speed with @Giammy_L ! #Ferroptosis #celldeath
Thrilled to share our latest paper in Cell Death Discovery! 👉 https://t.co/Ohd2eYMyqE Together with my fantastic co-senior and co-corresponding author @vonKarstedtLab , we uncovered that the BTK inhibitor ibrutinib has a previously unrecognized role in disrupting redox balance
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Thrilled to share our new paper in @ScienceAdvances 🚀We uncover a new mechanism that protects adipocytes from cell death during #obesity and #ageing — with major implications for metabolic syndrome, including #diabetes, #MASLD and #lipodystrophy.
science.org
LUBAC preserves adipose tissue integrity via cell death inhibition, preventing metabolic disorders during aging and obesity.
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Functional synapses between neurons and small cell lung cancer | Nature | I am beyond excited to share that our work on innervation of SCLC tumors is finally out. Non of this would have been possible without an entire army of friends and collaborators.
nature.com
Nature - Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.
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I am beyond excited and incredibly proud to share that our work is now out in @Nature . https://t.co/DaPQSUAdh2
nature.com
Nature - STING-activation-induced necroptosis (STAIN) is a central pathogenic mechanism in both caspase-8-deficient inflammation and STING-associated vasculopathy with onset in infancy.
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Excited to share our new preprint led by Kirandeep Deol! Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to #ferroptosis. https://t.co/AazDvtfBAF
biorxiv.org
Ferroptosis, a regulated form of cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic target in cancer. Ferroptosis suppressor protein 1 (FSP1) is a critical...
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Also see a new preprint from Pedro Angeli and colleagues that makes similar discoveries related to vitamin B2 / FSP1 stability and ferroptosis regulation: 👏🏽 https://t.co/A00aaNSDih
biorxiv.org
Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficie...
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The count down has begun! 1-week until the 1st FASEB Ferroptosis conference! Looking forward to seeing everyone at the meeting. Get excited!! 🤩 https://t.co/VlV9L3kxx1
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And it begins.. Cold Spring Harbor Asia on Ferroptosis in the beautiful city of Suzhou, China. Thank you @Conrad_Lab @bstockwell and the whole organising team..
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Please RT and help us get the word out. Scott Dixon @sjd956 and I are co-organizing the first @FASEBorg #Ferroptosis conference this summer! Awesome line up of speakers and room for additional short talks! Save the date & come join us July 27 - 31, 2025! 🤩 https://t.co/VlV9L3kxx1
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Sad I could not join this year but looking forward to the next 3 years of #SPP2306
🚀 Thrilled to announce the launch of Phase 2 funding for #SPP2306! After an incredibly productive first phase, we’re ready to push the boundaries of 🔬 science. Huge thanks to everyone for the inspiring discussions and groundbreaking ideas—let’s keep the momentum going! 🔥🔥
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1/ 📢 Our special issue on #celldeath is now live @NatureCellBio, which features Editorial, Reviews, Perspective, Comment, Research Highlights, Research Articles and so many more! 👉Click and enjoy the reading: https://t.co/fkO2Q1fkNp
https://t.co/YcbUj8JlIj
nature.com
Nature Cell Biology - This issue presents a Focus of specially commissioned articles that discuss cell death in its multiple forms, implications for homeostatic physiology and disease and...
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Very happy to announce that I have been awarded an ERC starting grant to open my own lab. Many people have helped me in achieving this big success, but first and foremost would like to thank my husband and my family for supporting me in this journey…
🎉 Congrats to @DeshwalSoni from @langer_lab on receiving the prestigious ERC Starting Grant! Her groundbreaking research on mitochondria's role in ferroptosis will pave the way for new insights into cell death and disease. 🌟🔬 #ERCStG @ERC_Research
https://t.co/M8W026FSZg
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Young parents new Performance Enhancer drug:acetate
New! Online now: Acetate enables metabolic fitness and cognitive performance during sleep disruption https://t.co/wHJI8vs2wZ
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Congrats to @mluzsoula on her farewell manuscript describing a role for tumor glycosphingolipids in immune evasion @RockefellerUniv
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Mark your calendars! The 1st FASEB #Ferroptosis conference, July 27-31 2025! We just posted our preliminary agenda! Spectacular line up and lots of space for short talks / late breaking speakers. Help us get the word out & come join us in 2025! @FASEBorg
https://t.co/VlV9L3jZHt
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