Taylor Stevens
@tstevens5000
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Graduate student at Caltech. Studying membrane protein biogenesis and quality control in the Voorhees lab. Sometimes I hike or travel.
Pasadena, CA
Joined January 2013
Highly recommend working with Stefan!
Excited to share that I'm starting a new research group at @uclachem and @cnsiatucla! We'll focus on the molecular architecture of tight junctions - barriers crucial for human health - using biochemical reconstitution, cryo-EM, X-ray crystallography, and cell-based assays.
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A long sought after hypothesis has been that organizing biomolecules in and around nuclear bodies is essential for functional RNA processing. We now provide direct evidence of this in @Nature for nuclear speckles and mRNA splicing. Check out this thread! https://t.co/DoXSB7SINt
nature.com
Nature - Nuclear speckles are shown to have a functional role in mRNA splicing, whereby dynamic three-dimensional organization of DNA around these structures mediates splicing efficiency.
What are the functional roles of 3D genome organization? Our paper in @Nature led by @_prashantbhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. https://t.co/8KwfJHQWTt
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Cool project to work on, congrats to all!
Excited to share my first paper from grad school out today in @MolecularCell! We systematically define biogenesis pathways for alpha-helical OMM proteins triaged by the NAC and TTC1 chaperone complexes for polytopic and signal-anchored proteins (1/2). https://t.co/UGB8yhKnBW
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Excited to share my first paper from grad school out today in @MolecularCell! We systematically define biogenesis pathways for alpha-helical OMM proteins triaged by the NAC and TTC1 chaperone complexes for polytopic and signal-anchored proteins (1/2). https://t.co/UGB8yhKnBW
cell.com
Muthukumar et al. use genome-wide and systematic arrayed CRISPRi screens to identify ⍺-helical OMM protein biogenesis and quality control factors that triage substrates by topology. They establish...
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Position Open: Postdoctoral Researcher, @pleinerlab, @Stanford, Stanford, CA https://t.co/XtAHEsrvA4 Find out more about this position as well as others in cell biology on ASCB's Job Board.
jobs.ascb.org
A new
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https://t.co/pAO0VoJ2cZ congrats to @annakarenorta @naditasofia and the rest of the @clemonslab who made this story possible. This is a long time coming.
caltech.edu
antibiotic resistance
We are absolutely thrilled to finally share our new structure from @clemonslab of escape mechanism of the smallest phages (φX174) by breaching the peptidoglycan layer, now out in Science! https://t.co/haFGabV5eE 🧵 In this thread, I'll give you a sneak peek of the YES complex👇🏼
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We are absolutely thrilled to finally share our new structure from @clemonslab of escape mechanism of the smallest phages (φX174) by breaching the peptidoglycan layer, now out in Science! https://t.co/haFGabV5eE 🧵 In this thread, I'll give you a sneak peek of the YES complex👇🏼
science.org
A structure reveals how a three-protein complex allows bacteriophages to kill and lyse host cells.
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Our lab is looking for postdocs! 🌴🌞 We value scientific and cultural diversity and collaborative science. If you think you could excited about membranes, mitochondria, or microscopes🔬, please get in touch! @HHMINEWS @Caltech @BMBCaltech
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Our latest work from @theJensenLab on cryo-ET of Legionella Dot/Icm T4SS is now available on @biorxiv. https://t.co/xYYlbrBVys Here are some key findings: 1/7
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Check out our nanobody-based protein purification protocol. We’ve had great results using this for a variety of applications including cryo-EM sample prep, IDing interaction partner via mass-spec, and functional/biochemical experiments. Very clean and high yield!
Purifying eukaryotic proteins & their complexes at the scale & purity needed for structural, functional or mass spec characterization can be a pain! Our new protocol preprint https://t.co/J5tBObCUwR describes how anti-GFP & ALFA tag nanobodies can make your life easier (1/6)
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Purifying eukaryotic proteins & their complexes at the scale & purity needed for structural, functional or mass spec characterization can be a pain! Our new protocol preprint https://t.co/J5tBObCUwR describes how anti-GFP & ALFA tag nanobodies can make your life easier (1/6)
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Cellular compartmentation requires stringent sorting of thousands of proteins to their correct destination. Our new pre-print https://t.co/U8VdOZPBN3 describes a novel source of specificity that controls sorting of aggregation prone membrane proteins to the correct organelle. 1/8
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This work opens a lot of new doors to studying mitochondrial protein biogenesis and quality control. If this sounds interesting to you, we're looking for postdocs to join us in Pasadena, CA @Caltech! Check out our website:
voorheeslab.caltech.edu
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With lots of new data from the pre-print! I think we finally have a (partial) answer to how alpha-helical proteins get inserted into the mitochondrial outer membrane in human cells. https://t.co/7ZBjtPGmXD
science.org
Mitochondrial carrier homolog 2 mediates the insertion of diverse alpha-helical proteins into the mitochondrial outer membrane.
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Check out our new preprint identifying MTCH2 as an mitochondrial outer membrane protein insertase in mammalian cells! Great collaboration with @voorheeslab @WhiteheadInst @Caltech
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For a nice summary of our work, see this tweetorial from @aj_inglis
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Our work on MTCH2 is out now! Great team effort with my fellow co-first authors @guna_alina @aj_inglis. Many thanks to @voorheeslab @JswLab and all others who helped carry this work forward.
science.org
Mitochondrial carrier homolog 2 mediates the insertion of diverse alpha-helical proteins into the mitochondrial outer membrane.
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If you’re not PhDing with @BMBCaltech are you even PhDing? Another great BMB student retreat. Thanks to our inspiring keynote Jose Rodriguez @Jose54509762 from UCLA.
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Check out this great summary from @aj_inglis of our work characterizing MTCH2 as a transmembrane helix insertase in the mitochondrial outer membrane (in human cells), which is now up on biorxiv. Really satisfying project to work on and a great team to be a part of!
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Happy to share the first project I worked on @NICHD_NIH under the late, great Phillip Gurnev in 2018: Restricting α-synuclein transport into mitochondria by inhibition of α-synuclein–VDAC complexation as a potential therapeutic target for Parkinson’s disease treatment (1/7)
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